X0306 4 2016-02-01 0 0000816284 CELGENE CORP /DE/ CELG 0001180469 MARIO ERNEST C/O CELGENE CORPORATION 86 MORRIS AVENUE SUMMIT NJ 07901 1 0 0 0 Common Stock 2016-02-01 4 M 0 18600 29.00 A 101049 D Common Stock 2574 I By Spouse Stock Option (right to buy) 29.00 2016-02-01 4 M 0 18600 0.00 D 2021-06-15 Common Stock 18600 0 D The reporting person disclaims beneficial ownership of these securities and this report shall not be deemed an admission that the reporting person is the beneficial owner of such securities for purposes of Section 16 or for any other purpose. The option was fully exercisable. The option was issued pursuant to the Celgene Corporation 2008 Stock Incentive Plan (Amended and Restated as of April 15, 2015). /s/ Robert J. Hugin _____________________________________________________ Robert J. Hugin, Attorney-in-Fact 2016-02-02