CONSOLIDATED STATEMENTS OF CASH FLOWS (USD $) In Thousands, unless otherwise specified	6 Months Ended
	Jun. 30, 2012	Jun. 30, 2011
Cash flows from operating activities:
Net income	$ 768,910	$ 534,294
Adjustments to reconcile net income to net cash provided by operating activities:
Depreciation	38,489	35,019
Amortization	86,568	140,249
Allocation of prepaid royalties	897	15,744
Provision for accounts receivable allowances	5,545	1,405
Deferred income taxes	174,695	(85,282)
Impairment of acquired in-process research and development	22,152	118,000
Change in value of contingent consideration	25,638	(111,169)
Share-based compensation expense	114,211	112,097
Share-based employee benefit plan expense	7,882	8,071
Unrealized and realized change in value of derivative instruments	(37,071)	8,874
Realized (gains) losses on marketable securities available for sale	(259)	1,455
Other, net	(7,989)	1,321
Change in current assets and liabilities, excluding the effect of acquisitions and dispositions:
Accounts receivable	37,431	(126,187)
Inventory	(34,043)	65,428
Other operating assets	194,076	12,952
Assets held for sale, net	(1,176)	1,290
Accounts payable and other operating liabilities	(71,005)	(35,551)
Income tax payable	(379,833)	43,526
Deferred revenue	2,291	(5,137)
Net cash provided by operating activities	947,409	736,399
Cash flows from investing activities:
Proceeds from sales of marketable securities available for sale	850,478	1,095,497
Purchases of marketable securities available for sale	(760,995)	(963,293)
Payments for acquisition of business, net of cash acquired	(352,246)
Proceeds from the sale of non-core assets, net	1,782	93,185
Capital expenditures	(59,249)	(53,048)
Purchases of investment securities	(29,225)	(533)
Other investing activities	(516)	(2,329)
Net cash provided by (used in) investing activities	(349,971)	169,479
Cash flows from financing activities:
Payment for treasury shares	(726,513)	(689,126)
Proceeds from short-term borrowing	2,624,316
Principal repayments on short-term borrowing	(2,759,762)
Net proceeds from exercise of common stock options and warrants	240,876	54,357
Excess tax benefit from share-based compensation arrangements	28,640	10,462
Net cash (used in) financing activities	(592,443)	(624,307)
Effect of currency rate changes on cash and cash equivalents	(1,980)	15,345
Net increase in cash and cash equivalents	3,015	296,916
Cash and cash equivalents at beginning of period	1,859,464	1,351,128
Cash and cash equivalents at end of period	1,862,479	1,648,044
Supplemental schedule of non-cash investing and financing activity:
Change in net unrealized (gain) loss on marketable securities available for sale	(1,539)	(4,804)
Matured shares tendered in connection with stock option exercises	(155)
Supplemental disclosure of cash flow information:
Interest paid	24,482	26,169
Income taxes paid	$ 172,387	$ 66,689