Share Based Compensation (Tables)

6 Months Ended

Jun. 30, 2011

Share-Based Compensation [Abstract]

Share based compensation expense

	Three-Month Periods Ended				Six-Month Periods Ended
	June 30,				June 30,
	2011		2010		2011		2010
Cost of good sold	$	2,419	$	1,602	$	4,427	$	3,121
Research and development		22,880		20,023		55,472		39,153
Selling, general and administrative		25,613		22,185		48,706		42,116
Total share-based compensation expense		50,912		43,810		108,605		84,390
Tax benefit related to share-based compensation expense		12,417		9,960		27,869		19,167
Reduction in income	$	38,495	$	33,850	$	80,736	$	65,223

Stock Option Transactions

						Weighted
				Weighted		Average Remaining		Aggregate
				Average Exercise		Contractual		Intrinsic Value
	Options			Price Per Option		Term (Years)		(In Thousands)
Outstanding at December 31, 2010		41,137,686		$	48.56		6.7	$	501,663
Changes during the Year:
Granted		5,164,811			56.30
Exercised		(1,950,575	)		32.67
Forfeited		(751,962	)		56.07
Expired		(216,637	)		64.72
Outstanding at June 30, 2011		43,383,323		$	49.99		6.7	$	500,939
Vested at June 30, 2011 or expected to vest in the future		42,518,400		$	49.86		6.6	$	497,071
Vested at June 30, 2011		22,147,932		$	44.07		4.9	$	392,397

Restricted Stock Units

				Weighted
				Average
	Share			Grant Date
Nonvested RSUs	Equivalent			Fair Value
Nonvested at December 31, 2010		1,510,384		$	54.84
Changes during the period:
Granted		1,282,600			58.44
Vested		(9,072	)		49.97
Forfeited		(34,819	)		52.72
Non-vested at March 31, 2011		2,749,093		$	56.56