February 11, 2010

Securities and Exchange Commission

100 F Street, N.E.

Washington, DC 20549-4720

Re:	American Century Variable Portfolios, Inc. (the "Registrant")
	1933 Act File No. 33-14567, Post-Effective Amendment No. 48
	1940 Act File No. 811-5188, Amendment No. 48

Ladies and Gentlemen:

Pursuant to Section 101(a) of Regulation S-T and Rule 485(a) under the Securities Act of 1933, the Registrant hereby submits for filing the following 1933 Act Post-Effective Amendment No. 48 and 1940 Act Amendment No. 48 to the Registrant’s Registration Statement on Form N-1A.

The principal purpose of the Amendment is to add a summary section to each fund’s prospectus to incorporate new Form N-1A items.

If there are any questions or comments regarding this filing, please contact the undersigned at (816) 340-3224.

Sincerely,

 /s/ Christine J. Crossley                                                                                       

Christine J. Crossley

Assistant Secretary

American Century Investments
P.O. Box 410141, 4500 Main Street	1-800-345-2021 or 816-531-5575
Kansas City, MO 64141-0141	www.americancentury.com