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Condensed Consolidated Statements of Cash Flows - USD ($)
3 Months Ended 12 Months Ended
Mar. 31, 2024
Mar. 31, 2023
Dec. 31, 2023
Dec. 31, 2022
Operating activities:        
Net loss $ (1,915,327) $ (1,046,109) $ (6,140,730) $ (13,798,339)
Adjustments to reconcile net loss to net cash used in operating activities:        
Amortization and depreciation 1,588 1,785 6,554 24,562
Non-cash lease expense 29,265 26,936 111,153 112,714
Share-based compensation 59,961 73,634 370,182 333,389
Issuance of common stock to vendors for services     73,000 212,003
Issuance of common stock for unexercised purchase option     50,000  
Loss on extinguishment of debt     393,791  
Change in fair value of convertible debt (165,382)   (43,066)  
Amortization of deferred issuance costs associated with convertible debt   10,242 12,518 41,538
Change in operating assets and liabilities:        
Contracts and grants receivable 54,225 (102,878) (56,124) 23,759
Prepaid expenses and other current assets 414,138 60,894 (591,805) 8,694
Research and development incentives receivable 17,379 98,456 90,016 73,374
Operating lease liability (29,359) (26,256) (108,948) (111,122)
Accounts payable and accrued expenses 391,929 (970,757) (2,685,073) 396,651
Accrued compensation (200,899) (292,200) (85,577) 33,756
Net cash used in operating activities (1,342,482) (2,166,253) (8,604,109) (12,649,021)
Investing activities:        
Purchases of office furniture and equipment       (13,073)
Net cash used in investing activities       (13,073)
Financing activities:        
Proceeds from issuance of common stock pursuant to B. Riley At Market Issuance Sales Agreement   70,730 3,091,462 79,354
Proceeds from issuance of common stock and pre-funded warrants pursuant to public offering     8,495,817  
Convertible debt repayments   (1,000,000) (7,000,000)  
Net cash used in financing activities (8,992) (931,558) 3,663,506 76,821
Effect of exchange rate on cash and cash equivalents (3,136) 4,046 27,146 (99,009)
Net decrease in cash and cash equivalents (1,354,610) (3,093,765) (4,913,457) (12,684,282)
Cash and cash equivalents at beginning of period 8,446,158 13,359,615 13,359,615 26,043,897
Cash and cash equivalents at end of period 7,091,548 10,265,850 8,446,158 13,359,615
Supplemental information:        
Cash paid for state income taxes 17,965 2,110 20,730 16,043
Cash paid for interest 64,047 213,490 552,058 857,411
Cash paid for lease liabilities:        
Operating lease 34,100 33,325 133,817 133,300
Non-cash investing and financing activities:        
Right-of-use assets and lease liabilities recorded       347,546
Pontifax conversion of portion of debt principal into common stock 99,416      
Deferred issuance cost reclassified to additional paid-in capital   53 20,208 60
Declaration of Series D preferred stock for stock dividend       43
Redemption liability for Series D preferred stock   43 43  
Public offering costs included in accounts payable 123,689      
B. Riley Sales Agreement        
Financing activities:        
Stock issuance costs associated   $ (2,288) (93,011) $ (2,533)
Public Offering        
Financing activities:        
Stock issuance costs associated $ (8,992)   (834,061)  
Pre-funded warrants        
Financing activities:        
Proceeds from the exercise of pre-funded warrants     $ 3,299