Exhibit 23.1

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

We consent to the inclusion in this Amendment No. 1 to Registration Statement of Soligenix, Inc. on Form S-1 (No. 333-276511) to be filed on or about March 15, 2024 of our report dated March 15, 2024, on our audit of the financial statements as of December 31, 2023 and for the year then ended. Our report includes an explanatory paragraph about the existence of substantial doubt concerning the Company’s ability to continue as a going concern. We also consent to the reference to our firm under the caption “Experts” in this Registration Statement.

/s/ Cherry Bekaert LLP

CHERRY BEKAERT LLP

Tampa, Florida

March 15, 2024