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Condensed Consolidated Statements of Cash Flows - USD ($)
9 Months Ended 12 Months Ended
Sep. 30, 2023
Sep. 30, 2022
Dec. 31, 2022
Dec. 31, 2021
Operating activities:        
Net loss $ (4,320,835) $ (10,044,784) $ (13,798,339) $ (12,550,973)
Adjustments to reconcile net loss to net cash used in operating activities:        
Amortization and depreciation 4,964 21,538 24,562 34,161
Non-cash lease expense 82,500 86,326 112,714 116,290
Share-based compensation 229,076 220,656 333,389 361,559
Issuance of common stock to vendors for services 73,000 150,002 212,003 27,500
Issuance of common stock to Silk Roads for purchase option 50,000      
Loss on extinguishment of debt 393,791     (421,584)
Change in fair value of convertible debt (387,537)      
Amortization of deferred issuance costs associated with convertible debt 12,518 31,068 41,538 41,926
Change in operating assets and liabilities:        
Licensing, contracts and grants receivable 49,079 8,147 23,759 64,885
Prepaid expenses and other current assets (310,229) (113,452) 8,694 (57,430)
Research and development incentives receivable 92,092 67,912 73,374 205,237
Operating lease liability (80,458) (85,415) (111,122) (116,290)
Deferred revenue   200,000    
Accounts payable and accrued expenses (2,382,708) 679,268 396,651 1,127,259
Accrued compensation (281,149) (243,146) 33,756 (572,160)
Net cash used in operating activities (6,775,896) (9,021,880) (12,649,021) (11,739,620)
Investing activities:        
Purchases of office furniture and equipment   (13,073) (13,073) (11,789)
Net cash used in investing activities   (13,073) (13,073) (11,789)
Financing activities:        
Proceeds from issuance of common stock pursuant to B. Riley At Market Issuance Sales Agreement 3,091,462   79,354 19,705,647
Stock issuance costs associated     (2,533) (621,899)
Proceeds from issuance of common stock and pre-funded warrants pursuant to public offering 8,495,817      
Convertible debt repayments (7,000,000)      
Net cash provided by financing activities 3,709,688   76,821 19,058,001
Proceeds from the exercise of warrants       79
Proceeds from the exercises of stock options       25,835
Costs associated with issuance of convertible debt       (45,512)
Principal repayment - financing lease       (6,149)
Effect of exchange rate on cash and cash equivalents 5,127 (143,302) (99,009) 60,642
Net decrease in cash and cash equivalents (3,061,081) (9,178,255) (12,684,282) 7,367,234
Cash and cash equivalents at beginning of period 13,359,615 26,043,897 26,043,897 18,676,663
Cash and cash equivalents at end of period 10,298,534 16,865,642 13,359,615 26,043,897
Supplemental information:        
Cash paid for state income taxes 13,006 13,243 16,043 7,727
Cash paid for interest 488,011 643,921 857,411 668,715
Cash paid for lease liabilities:        
Operating lease 99,975 99,975 133,300 133,300
Financing lease       6,408
Non-cash investing and financing activities:        
Right-of-use assets and lease liabilities recorded   $ 347,546 347,546  
Deferred issuance cost reclassified to additional paid-in capital 2,339   60 $ 33,257
Redemption liability for Series D preferred stock 43      
Stock issuance costs included in accounts payable 46,180      
Declaration of Series D preferred stock     $ 43  
At Market Issuance Sales Agreement        
Financing activities:        
Stock issuance costs associated (93,009)      
Public Offering        
Financing activities:        
Stock issuance costs associated (787,881)      
Pre-funded warrants        
Financing activities:        
Proceeds from the exercise of pre-funded warrants $ 3,299