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Summary of Significant Accounting Policies - Loss per share, Warrants and Options expirations (Details) - $ / shares
12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Dec. 31, 2020
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]      
Securities excluded 355,542 525,470  
Weighted average exercise price, outstanding options $ 27.56 $ 37.12 $ 44.41
Warrants      
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]      
Securities excluded 667 221,872  
Stock options      
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]      
Securities excluded 192,273 140,996  
Convertible debt securities      
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]      
Securities excluded 162,602 162,602