X0303 4 2010-09-23 0 0000812796 SOLIGENIX, INC. SNGX 0001050955 MYRIANTHOPOULOS EVAN 29 EMMONS DRIVE SUITE C-10 PRINCETON NJ 08540 1 1 0 0 CFO and Senior Vice Presient Stock Option (Right to Buy) 0.232 2010-09-23 4 A 0 1050000 0 A 2010-09-23 2020-06-30 Common Stock 1050000 1050000 D The option grant was approved by the compensation committee of the board of directors of Soligenix, Inc. (the "Company") on July 1, 2010, subject to stockholder approval of an amendment to the Company's 2005 Equity Incentive Plan (the "Plan") to increase the maximum number of shares of common stock available for issuance under the Plan. The Company's stockholders approved the amendment to the Plan on September 23, 2010. The stock option vested as to 262,500 shares on July 1, 2010 with the remainder vesting quarterly in equal amounts on each three (3) month anniversary of July 1, 2010 for the next three years. /s/ Evan Myrianthopoulos 2010-09-23