January 23, 2018

VIA EDGAR

United States Securities and Exchange Commission

Office of Financial Services

100 F Street, N.E.

Washington, D.C. 20549

Attention: Era Anagnosti

Re: Santander Holdings USA, Inc.

Registration Statement on Form S-4

File No. 333-222511

Request for Acceleration

Dear Ms. Anagnosti:

In accordance with Rules 460 and 461 under the Securities Act of 1933, as amended, Santander Holdings USA, Inc. hereby requests that its Registration Statement on Form S-4 filed with the Securities and Exchange Commission on January 11, 2018 (File No. 333-222511) be made effective at 4:30 p.m. New York City time on January 25, 2018, or as soon as possible thereafter.

Please contact Kathryn Gettles-Atwa of Wachtell, Lipton, Rosen & Katz at (212) 403-1142 or by email at KGettles-Atwa@wlrk.com with any questions you may have concerning this request. In addition, please notify Ms. Gettles-Atwa when this request for acceleration has been granted.

[SIGNATURE PAGE FOLLOWS]

SANTANDER HOLDINGS USA, INC.
By:	/s/ Gerard A. Chamberlain
Name:	Gerard A. Chamberlain
Title:	Senior Vice President and Assistant Secretary

cc: Mark F. Veblen, Wachtell, Lipton, Rosen & Katz

Kathryn Gettles-Atwa, Wachtell, Lipton, Rosen & Katz