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Note 12 - Stockholders' Equity (Tables)
12 Months Ended
Dec. 31, 2021
Notes Tables  
Schedule of Stockholders' Equity Note, Warrants or Rights [Table Text Block]
  

Number of

Shares

  

Weighted-

Average Exercise

Price Per Share

  

Weighted-Average

Remaining

Contract Term

 

Balance at January 1, 2020

  1,716,066  $25.23   1.57 

Warrants granted

    $     

Warrants exercised

  (599,582) $2.81     

Warrants expired/canceled

    $     

Outstanding at December 31, 2020

  1,116,484  $37.27   0.49 

Exercisable at December 31, 2020

  1,046,631  $34.42   0.54 
             

Balance at January 1, 2021

  1,116,484  $37.27   0.49 

Warrants granted

    $     

Warrants exercised

    $     

Warrants expired/canceled

  (463,236) $80     

Outstanding and Exercisable at December 31, 2021

  653,248  $6.97   1.4 
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]
  

Year Ended December 31,

 
  

2021

  

2020

 

Cost of revenues

 $17,000  $9,000 

Selling, general and administrative

  2,275,000   757,000 

Research and development

  268,000   114,000 
  $2,560,000  $880,000 
Share-based Payment Arrangement, Option, Activity [Table Text Block]
  

Number

of Shares

  

Weighted-

Average

Exercise

Price

  

Weighted-

Average

Remaining

Contractual

Life

  

Aggregate

Intrinsic

Value

 

Outstanding at January 1, 2021

  889,636  $8.57   8.7  $-- 
                 
                 

Granted

  --             

Expired

  (766) $272.21      $-- 

Forfeited/cancelled

  (535,450) $5.89      $-- 

Outstanding at December 31, 2021

  353,420  $12.04   6.8  $-- 

Vested and Expected to Vest at December 31, 2021

  326,596  $12.46   6.7  $-- 

Exercisable at December 31, 2021

  279,520  $13.29   6.6  $-- 
Non Vested Stock Options Activity [Table Text Block]
  

Non-vested Stock

Options

  

Weighted-Average

Grant Date Fair Value

 

Outstanding at January 1, 2021

  658,800  $5.25 

Granted

  --     

Vested

  (61,400) $6.18 

Cancelled/forfeited

  (523,500) $5.05 

Outstanding at December 31, 2021

  73,900  $5.94 
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
  

Year Ended December 31,

 
  

2020

 

Expected life (years)

  6 

Expected volatility

  116%

Risk-free interest rate

  0.54%

Dividend yield

  0%
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
  

2021

  

2020

 

Common stock equivalents of convertible promissory notes and accrued interest

  7,960,811   7,300,897 

Vested Series A warrants

  --   40,441 

Unvested Series A warrants(1)

  --   69,853 

Warrants – other

  653,248   1,006,190 

Stock options

  326,596   889,636 

Total

  8,940,655   9,307,017