Note 4 - Intangible Assets and Goodwill - Summary of Intangible Assets (Details) - USD ($)	12 Months Ended
	Dec. 31, 2018	Dec. 31, 2017
Gross Carrying Amount	$ 1,355,000	$ 1,445,000
Accumulated Amortization	891,000	829,000
Net	448,000	616,000
Impairment	16,000
Gross Carrying Amount	22,368,000	22,458,000
Impairment of Intangible Assets (Excluding Goodwill), Total	19,886,000
Net	1,591,000	21,629,000
In Process Techonology [Member]
Gross Carrying Amount	1,143,000	1,143,000
Impairment
Net	1,143,000
Clinical Protocols [Member]
Gross Carrying Amount	19,870,000	$ 19,870,000
Impairment	19,870,000
Net
Trade Names [Member]
Finite-Lived Intangible Asset, Useful Life	3 years	7 years
Gross Carrying Amount	$ 54,000	$ 56,000
Accumulated Amortization	38,000	21,000
Net	$ 16,000	$ 35,000
Developed Technology Rights [Member]
Finite-Lived Intangible Asset, Useful Life	10 years	10 years
Gross Carrying Amount	$ 318,000	$ 318,000
Accumulated Amortization	48,000	16,000
Net	$ 270,000	$ 302,000
Licensing Agreements [Member]
Finite-Lived Intangible Asset, Useful Life	7 years	7 years
Gross Carrying Amount	$ 448,000	$ 489,000
Accumulated Amortization	307,000	271,000
Net	$ 141,000	$ 218,000
Device Registration [Member]
Finite-Lived Intangible Asset, Useful Life	7 years	7 years
Gross Carrying Amount	$ 84,000	$ 92,000
Accumulated Amortization	68,000	65,000
Net		$ 27,000
Impairment	$ 16,000
Customer Relationships [Member]
Finite-Lived Intangible Asset, Useful Life	3 years	3 years
Gross Carrying Amount	$ 451,000	$ 490,000
Accumulated Amortization	430,000	456,000
Net	21,000	$ 34,000
Impairment