<SEC-DOCUMENT>0001437749-22-029603-index.html : 20221222
<SEC-HEADER>0001437749-22-029603.hdr.sgml : 20221222
<ACCEPTANCE-DATETIME>20221222161907
ACCESSION NUMBER:		0001437749-22-029603
CONFORMED SUBMISSION TYPE:	S-8
PUBLIC DOCUMENT COUNT:		6
REFERENCES 429:			333-198716
REFERENCES 429:			333-228960
REFERENCES 429:			333-250078
FILED AS OF DATE:		20221222
DATE AS OF CHANGE:		20221222
EFFECTIVENESS DATE:		20221222

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			NAVIDEA BIOPHARMACEUTICALS, INC.
		CENTRAL INDEX KEY:			0000810509
		STANDARD INDUSTRIAL CLASSIFICATION:	IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES [2835]
		IRS NUMBER:				311080091
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		S-8
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-268956
		FILM NUMBER:		221482205

	BUSINESS ADDRESS:	
		STREET 1:		4995 BRADENTON AVENUE
		STREET 2:		SUITE 240
		CITY:			DUBLIN
		STATE:			OH
		ZIP:			43017
		BUSINESS PHONE:		6147937500

	MAIL ADDRESS:	
		STREET 1:		4995 BRADENTON AVENUE
		STREET 2:		SUITE 240
		CITY:			DUBLIN
		STATE:			OH
		ZIP:			43017

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	NEOPROBE CORP
		DATE OF NAME CHANGE:	19940714
</SEC-HEADER>
<DOCUMENT>
<TYPE>S-8
<SEQUENCE>1
<FILENAME>navb20221221_s8.htm
<DESCRIPTION>FORM S-8
<TEXT>
Document 1 - file: navb20221221_s8.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-5.1
<SEQUENCE>2
<FILENAME>ex_458445.htm
<DESCRIPTION>EXHIBIT 5.1
<TEXT>
Document 2 - file: ex_458445.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-10.1
<SEQUENCE>3
<FILENAME>ex_458446.htm
<DESCRIPTION>EXHIBIT 10.1
<TEXT>
Document 3 - file: ex_458446.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-23.2
<SEQUENCE>4
<FILENAME>ex_458468.htm
<DESCRIPTION>EXHIBIT 23.2
<TEXT>
Document 4 - file: ex_458468.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-FILING FEES
<SEQUENCE>5
<FILENAME>ex_458447.htm
<DESCRIPTION>EXHIBIT FILING FEES
<TEXT>
Document 5 - file: ex_458447.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>6
<FILENAME>ex_458445img001.jpg
<TEXT>
Document 6 - file: ex_458445img001.jpg

</DOCUMENT>
</SEC-DOCUMENT>