X0306 4 2022-09-09 0000810509 NAVIDEA BIOPHARMACEUTICALS, INC. NAVB 0001762349 Rosol Michael Stanley 4995 BRADENTON AVE., SUITE 240 DUBLIN OH 43017 1 Chief Medical Officer Common Stock 2022-09-09 4 A 0 28150 0 A 42725 D Common Stock 2022-09-09 4 A 0 13000 0 A 55725 D Common Stock 11320 I Held by 401(k) Plan The Reporting Person elected to receive stock in lieu of a cash bonus. The number of shares was determined based on the closing price on the date of grant, September 9, 2022. Stock Issued under the Amended and Restated 2014 Stock Incentive Plan. /s/ Erika L. Eves for Michael S. Rosol, by power of attorney 2022-09-13