<SEC-DOCUMENT>0001437749-22-016469-index.html : 20220701
<SEC-HEADER>0001437749-22-016469.hdr.sgml : 20220701
<ACCEPTANCE-DATETIME>20220701172921
ACCESSION NUMBER:		0001437749-22-016469
CONFORMED SUBMISSION TYPE:	S-1/A
PUBLIC DOCUMENT COUNT:		3
FILED AS OF DATE:		20220701
DATE AS OF CHANGE:		20220701

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			NAVIDEA BIOPHARMACEUTICALS, INC.
		CENTRAL INDEX KEY:			0000810509
		STANDARD INDUSTRIAL CLASSIFICATION:	IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES [2835]
		IRS NUMBER:				311080091
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		S-1/A
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-262691
		FILM NUMBER:		221062484

	BUSINESS ADDRESS:	
		STREET 1:		4995 BRADENTON AVENUE
		STREET 2:		SUITE 240
		CITY:			DUBLIN
		STATE:			OH
		ZIP:			43017
		BUSINESS PHONE:		6147937500

	MAIL ADDRESS:	
		STREET 1:		4995 BRADENTON AVENUE
		STREET 2:		SUITE 240
		CITY:			DUBLIN
		STATE:			OH
		ZIP:			43017

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	NEOPROBE CORP
		DATE OF NAME CHANGE:	19940714
</SEC-HEADER>
<DOCUMENT>
<TYPE>S-1/A
<SEQUENCE>1
<FILENAME>navb20220630_s1a.htm
<DESCRIPTION>FORM S-1/A
<TEXT>
Document 1 - file: navb20220630_s1a.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-23.1
<SEQUENCE>2
<FILENAME>ex_392027.htm
<DESCRIPTION>EXHIBIT 23.1
<TEXT>
Document 2 - file: ex_392027.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>3
<FILENAME>navb20220211_s1img001.jpg
<TEXT>
Document 3 - file: navb20220211_s1img001.jpg

</DOCUMENT>
</SEC-DOCUMENT>