X0306 4 2021-11-15 0000810509 NAVIDEA BIOPHARMACEUTICALS, INC. NAVB 0001753763 Scott John K Jr. 30 BLUE HERON DR. GREENWOOD VILLAGE CO 80121 1 1 Common Stock 2021-11-15 4 A 0 30000 0.001 A 8077162 D Common Stock 2021-11-15 4 A 0 2483 0 A 8079645 D Common Stock 2021-11-30 4 A 0 1250 0 A 8080895 D Common Stock 10139 I By spouse and children Restricted shares granted pursuant to Issuer's 2014 Amended and Restated Stock Incentive Plan which vest as to one-third on each of the first three anniversaries of the date of grant. Stock issued under the Amended and Restated 2014 Stock Incentive Plan in partial payment of quarterly non-employee director fees. Stock issued under the Amended and Restated 2014 Stock Incentive Plan in partial payment of monthly non-employee director fees. Issuance deferred at the request of the Reporting Person. Includes 2,639 shares of Common Stock owned by the Reporting Person's spouse and 7,500 shares of Common Stock owned by the Reporting Person's children. The Reporting Person may be deemed to have shared voting and/or dispositive power with respect to such shares. /s/ Erika L. Eves for John K. Scott, Jr. by power of attorney 2021-12-02