<SEC-DOCUMENT>0001437749-21-002502-index.html : 20210211
<SEC-HEADER>0001437749-21-002502.hdr.sgml : 20210211
<ACCEPTANCE-DATETIME>20210211082714
ACCESSION NUMBER:		0001437749-21-002502
CONFORMED SUBMISSION TYPE:	S-3/A
PUBLIC DOCUMENT COUNT:		5
FILED AS OF DATE:		20210211
DATE AS OF CHANGE:		20210211

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			NAVIDEA BIOPHARMACEUTICALS, INC.
		CENTRAL INDEX KEY:			0000810509
		STANDARD INDUSTRIAL CLASSIFICATION:	IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES [2835]
		IRS NUMBER:				311080091
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		S-3/A
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-252847
		FILM NUMBER:		21616881

	BUSINESS ADDRESS:	
		STREET 1:		4995 BRADENTON AVENUE
		STREET 2:		SUITE 240
		CITY:			DUBLIN
		STATE:			OH
		ZIP:			43017
		BUSINESS PHONE:		6147937500

	MAIL ADDRESS:	
		STREET 1:		4995 BRADENTON AVENUE
		STREET 2:		SUITE 240
		CITY:			DUBLIN
		STATE:			OH
		ZIP:			43017

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	NEOPROBE CORP
		DATE OF NAME CHANGE:	19940714
</SEC-HEADER>
<DOCUMENT>
<TYPE>S-3/A
<SEQUENCE>1
<FILENAME>navb20210210_s3a.htm
<DESCRIPTION>FORM S-3/A
<TEXT>
Document 1 - file: navb20210210_s3a.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-5.1
<SEQUENCE>2
<FILENAME>ex_225853.htm
<DESCRIPTION>EXHIBIT 5.1
<TEXT>
Document 2 - file: ex_225853.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>3
<FILENAME>letterheadb.jpg
<TEXT>
Document 3 - file: letterheadb.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>4
<FILENAME>letterheadlogo01.jpg
<TEXT>
Document 4 - file: letterheadlogo01.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>5
<FILENAME>letterheadlogo02.jpg
<TEXT>
Document 5 - file: letterheadlogo02.jpg

</DOCUMENT>
</SEC-DOCUMENT>