<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0206</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2014-02-17</periodOfReport>

    <noSecuritiesOwned>1</noSecuritiesOwned>

    <issuer>
        <issuerCik>0000810509</issuerCik>
        <issuerName>NAVIDEA BIOPHARMACEUTICALS, INC.</issuerName>
        <issuerTradingSymbol>NAVB</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001260573</rptOwnerCik>
            <rptOwnerName>KARSEN PERRY A</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>425 METRO PLACE NORTH</rptOwnerStreet1>
            <rptOwnerStreet2>SUITE 450</rptOwnerStreet2>
            <rptOwnerCity>DUBLIN</rptOwnerCity>
            <rptOwnerState>OH</rptOwnerState>
            <rptOwnerZipCode>43017</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable></nonDerivativeTable>

    <derivativeTable></derivativeTable>

    <footnotes></footnotes>

    <remarks>EXHIBIT INDEX
Exhibit 24 - Power of Attorney</remarks>

    <ownerSignature>
        <signatureName>William J. Kelly, Jr., Attorney-In-Fact</signatureName>
        <signatureDate>2014-02-18</signatureDate>
    </ownerSignature>
</ownershipDocument>
