X0306 4 2018-03-19 0 0001448431 OptimizeRx Corp OPRX 0000806968 WPP plc 27 FARM STREET LONDON X0 W1J 5RJ UNITED KINGDOM 0 0 1 0 0001626653 WPP Luxembourg Gamma Three S.a.r.l. 124 BOULEVARD DE LA PETRUSSE LUXEMBOURG N4 L-2330 LUXEMBOURG 0 0 1 0 Common Stock 2018-03-19 4 J 0 300000 1.50 A 6311106 I See Footnote The 300,000 shares of Common Stock of the Issuer (the "Shares") were acquired by WPP Luxembourg Gamma Three S.a r.l. ("Lux Gamma Three") from the Issuer on March 19, 2018. The Shares were issued pursuant to a Termination Letter (the "Termination Letter") dated as of February 23, 2018 between the Issuer and Grey Healthcare Group, LLC, an affiliate of Lux Gamma Three ("GHG"), as consideration for GHG's performance of its obligations pursuant to the Amended and Restated Co-Marketing Agreement dated as of September 24, 2015, between the Issuer and GHG, which was terminated by such Termination Letter. The price reported in column 4 is the price as of market close on March 16, 2018, the trading day preceding the acquisition. These shares are owned directly by Lux Gamma Three, which is a wholly-owned subsidiary of WPP plc that WPP plc owns indirectly through a series of intervening holding companies. WPP plc is an indirect beneficial owner of the reported securities. WPP plc, By: /s/ Paul W.G. Richardson, Group Finance Director 2018-05-11 WPP Luxembourg Gamma Three S.a r. l., By: /s/ Anne Ehrismann, Manager 2018-05-11 WPP Luxembourg Gamma Three S.a r. l., By: /s/ Thierry Lenders, Manager 2018-05-11