Adjusted free cash flow income.

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Cash sweep as percentage of cash proceeds.

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Cash sweep as percentage of consolidated free cash flow.

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Cash sweep as percentage of consolidated free cash flow upon conditions.

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Debt instrument additional interest rate stated percentage rate.

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Debt instrument convertible amended conversion price.

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Line of credit facility additional borrowings.

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Minimum percentage of common stock outstanding to provide continuity to nominee on board.

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Minimum required cash balance.

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Minimum required cash balance under condition.

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Net proceeds of secured loan agreement.

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Number of borrowings.

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Percentage of royalty paid on net sales.

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Percentage of royalty paid on net sales under condition one.

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Percentage of royalty paid on net sales under condition two.

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Period to prepay certain loans and notes.

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Royalty agreement date.

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Carrying amount as of the balance sheet date of obligations royalty payable to related parties. For classified balance sheets, represents the current portion of such liabilities (due within one year or within the normal operating cycle if longer).

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Royalty term description.

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Amount of currency on hand as well as demand deposits with banks or financial institutions. Includes other kinds of accounts that have the general characteristics of demand deposits. Excludes cash and cash equivalents within disposal group and discontinued operation.

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Reference 1: http://www.xbrl.org/2003/role/presentationRef
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-Name Accounting Standards Codification
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Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

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No definition available.

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The number of shares issued in exchange for the original debt being converted in a noncash (or part noncash) transaction. "Part noncash" refers to that portion of the transaction not resulting in cash receipts or payments in the period.

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The price per share of the conversion feature embedded in the debt instrument.

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Identification of the lender and information about a contractual promise to repay a short-term or long-term obligation, which includes borrowings under lines of credit, notes payable, commercial paper, bonds payable, debentures, and other contractual obligations for payment. This may include rationale for entering into the arrangement, significant terms of the arrangement, which may include amount, repayment terms, priority, collateral required, debt covenants, borrowing capacity, call features, participation rights, conversion provisions, sinking-fund requirements, voting rights, basis for conversion if convertible and remarketing provisions. The description may be provided for individual debt instruments, rational groupings of debt instruments, or by debt in total.

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Face (par) amount of debt instrument at time of issuance.

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Contractual interest rate for funds borrowed, under the debt agreement.

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Description of the interest rate as being fixed or variable, and, if variable, identification of the index or rate on which the interest rate is based and the number of points or percentage added to that index or rate to set the rate, and other pertinent information, such as frequency of rate resets.

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Date the debt instrument was issued, in CCYY-MM-DD format.

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Date when the debt instrument is scheduled to be fully repaid, in CCYY-MM-DD format.

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Discussion of the facts and amounts pertaining to each failure to comply with an affirmative or negative covenant of a long-term debt instrument, including violating payment terms or an inability to meet certain minimum financial requirements or achieve or maintain certain financial ratios. The discussion would generally be expected to also include whether or not the failure can and will be overcome and a description of the terms of any waivers, including the amount of the waiver and the period of time covered by the waiver, and if reclassification of long-term debt to current has been made in the current balance sheet.

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Description of the terms of a credit facility arrangement. Terms typically include interest rate, collateral required, guarantees required, repayment requirements, and restrictions on use of assets and activities of the entity.

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Maximum borrowing capacity under the credit facility without consideration of any current restrictions on the amount that could be borrowed or the amounts currently outstanding under the facility.

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Sum of the carrying values as of the balance sheet date of the portions of all long-term notes and loans payable due within one year or the operating cycle if longer.

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Cash received from collaborators during the current period.

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A fee charged for services from professionals such as doctors, lawyers and accountants. The term is often expanded to include other professions, for example, pharmacists charging to maintain a medicinal profile of a client or customer.

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Notes Payable - Additional Information (Detail)					1 Months Ended	12 Months Ended
Notes Payable - Additional Information (Detail)	Dec. 31, 2015 USD ($) $ / shares shares	Nov. 26, 2015 USD ($)	Oct. 26, 2015 USD ($)	Aug. 20, 2014 USD ($) Borrowing	Oct. 31, 2015 USD ($)	Dec. 31, 2015 USD ($) $ / shares shares	Dec. 31, 2014 USD ($)	Jul. 01, 2015 USD ($)	Apr. 06, 2015 USD ($)	Jan. 06, 2015 USD ($)	Nov. 04, 2014 USD ($)	Oct. 17, 2012 USD ($)	Jun. 08, 2010 USD ($)	May. 16, 2006 $ / shares	Sep. 26, 2005 USD ($)
Class of Warrant or Right [Line Items]
Maximum borrowing capacity				$ 20,000,000
Number of borrowings \| Borrowing				5
Minimum cash balance	$ 10,000,000					$ 10,000,000
Minimum cash balance under certain circumstances	15,000,000					15,000,000
Cash balance	12,600,000					12,600,000
Royalties payable under the Royalty Agreement	$ 208,000					$ 208,000
Loan maturity description						Loan will mature on the earlier of (a) December 31, 2019, and, (b) 30 days after the end of any fiscal year in which the Company's cash (plus certain cash expenditures during such fiscal year that are unrelated to the B12 Product or related products) as of the end of such fiscal year (subject to certain permitted deductions) is more than three times the principal amount of the Loan as of the end of such fiscal year.
Interest rate	13.00%					13.00%
Debt instrument interest rate terms						Interest at a rate of 13% per annum (the "Interest Rate"), compounded monthly, and will be payable in kind and in arrears on June 30 and December 31 of each year
Cash sweep as percentage of Consolidated Free Cash Flow						75.00%
Cash sweep as percentage of Consolidated Free Cash Flow upon conditions						75.00%
Cash sweep value						$ 50,000,000
Cash sweep as percentage of cash proceeds						50.00%
Payment received from Novo Nordisk			$ 14,000,000		$ 14,000,000
Debt instrument, description						On August 20, 2014, the Lenders and the Company further amended and restated (i) the Convertible Notes issued by the Company to certain of the Lenders, (ii) the Bridge Notes issued by the Company to certain of the Lenders, and (iii) the Reimbursement Notes (and, together with the Convertible Notes and Bridge Notes, the "MHR Notes").
Net proceeds of secured loan agreement															$ 12,900,000
Conversion price per share \| $ / shares														$ 3.78
11% Senior secured convertible notes loan agreement, execution date						May 16, 2006
Restructuring initiation date						Aug. 20, 2014
Minimum percentage of common stock outstanding to provide continuity to Mutual Nominee on Board						2.00%
Convertible Notes [Member]
Class of Warrant or Right [Line Items]
Principal amount	$ 46,500,000					$ 46,500,000
Interest rate	13.00%					13.00%
Cash sweep as percentage of Consolidated Free Cash Flow						50.00%
Cash sweep value						$ 50,000,000
Cash sweep as percentage of cash proceeds						50.00%
Conversion price per share \| $ / shares	$ 1.25					$ 1.25
Maturity date						Mar. 31, 2022
Shares of common stock \| shares						37,233,561
Royalty Agreement [Member]
Class of Warrant or Right [Line Items]
Royalty agreement date						Aug. 20, 2014
Net sales percentage on royalty agreement	20.00%					20.00%
Net sales percentage on royalty agreement	5.00%					5.00%
Net sales percentage on royalty agreement	2.50%					2.50%
Royalty agreement description						(i) five percent (5%) of all Net Sales and third party payments commencing with the first quarter immediately following the quarter in which the Indebtedness Repayment Condition is satisfied, or (ii) two and one half percent (2.5%) of all Net Sales commencing with the quarter immediately following the quarter in which the Indebtedness Repayment Condition is satisfied, but only with respect to the Net Sales made in any country in which there was not a Valid Patent Claim (as defined in the Royalty Agreement) and where generic entry of a competitive product not by the Company or its affiliates that does not infringe a Valid Patent Claim in such country has occurred, in each case as of the last day of such Fiscal Quarter.
Maximum [Member]
Class of Warrant or Right [Line Items]
Additional borrowings capacity								$ 2,000,000
Period on certain loans and notes						1 year
MHR Promissory Notes [Member]
Class of Warrant or Right [Line Items]
Principal amount													$ 600,000		$ 15,000,000
Interest rate															11.00%
Additional interest rate as an event of default						2.00%
Restructuring initiation date						May 07, 2013
MHR Promissory Notes [Member] \| Royalty Agreement [Member]
Class of Warrant or Right [Line Items]
Professional fees							$ 225,000
Loan Agreement [Member]
Class of Warrant or Right [Line Items]
Maximum borrowing capacity	$ 20,000,000					$ 20,000,000
Principal amount	22,800,000			$ 5,000,000		$ 22,800,000		$ 2,000,000	$ 5,000,000	$ 5,000,000	$ 3,000,000
Cash sweep as percentage of Consolidated Free Cash Flow						50.00%
Maturity date						Dec. 31, 2019
Reimbursement Notes [Member]
Class of Warrant or Right [Line Items]
Principal amount	$ 800,000					$ 800,000
Interest rate	10.00%					10.00%
Debt instrument interest rate terms						Interest at the rate of 10% per annum, compounded monthly, which interest is payable in the form of additional Reimbursement Notes.
Cash sweep as percentage of Consolidated Free Cash Flow						50.00%
Prepayment of notes and loans		$ 800,000
Notes and loans payable	$ 800,000					$ 800,000
Conversion price per share \| $ / shares	$ 0.50					$ 0.50
Restructuring initiation date						Aug. 20, 2014
Maturity date						Mar. 31, 2022
Shares of common stock \| shares	1,510,682
Bridge Notes [Member]
Class of Warrant or Right [Line Items]
Principal amount	$ 2,100,000					$ 2,100,000						$ 1,400,000
Interest rate	13.00%					13.00%
Debt instrument interest rate terms						Interest at 13% per year, compounded monthly and payable in the form of additional Bridge Notes.
Cash sweep as percentage of Consolidated Free Cash Flow						50.00%
Maturity date						Mar. 31, 2022
Shares of common stock \| shares	4,229,826
Convertible Notes default description						The Bridge Notes were amended and restated on May 7, 2013 and restated again on August 20, 2014.
Debt instrument convertible amended conversion price \| $ / shares						$ 0.50
Loans Payable [Member]
Class of Warrant or Right [Line Items]
Prepayment of notes and loans		$ 6,200,000
Notes and loans payable	$ 6,200,000					$ 6,200,000