Notes Payable and Restructuring of Debt (Details Textual) (USD $)	1 Months Ended	12 Months Ended									12 Months Ended				7 Months Ended	12 Months Ended				12 Months Ended
	Jun. 30, 2010	Dec. 31, 2012	Dec. 31, 2010	Sep. 27, 2012	Dec. 31, 2011	May 16, 2006	Sep. 26, 2005	Dec. 31, 2012 Novartis [Member]	Jun. 04, 2010 Novartis [Member]	Dec. 01, 2004 Novartis [Member]	Dec. 31, 2012 Legal and other transaction costs [Member]	Dec. 31, 2012 Reimbursement of MHR's legal fees [Member]	Dec. 31, 2012 Issuance Costs, MHR Convertible Notes [Member]	Dec. 31, 2012 Issuance costs, related derivative instruments allotment [Member]	Dec. 31, 2012 Legal fees incurred in connection with the Non-Disturbance Agreement [Member]	Dec. 31, 2012 Legal fees incurred in connection with the Non-Disturbance Agreement [Member]	Dec. 31, 2012 Legal expenses incurred by MHR in connection with the Future Transaction Agreement [Member]	Dec. 31, 2012 Face Amounts of 50000 [Member]	Dec. 31, 2012 Face Amounts of 100000 [Member]	Dec. 31, 2012 MHR Loan Agreement [Member]	Dec. 31, 2012 MHR Convertible Notes [Member]	Sep. 27, 2012 MHR Convertible Notes [Member]	Sep. 26, 2012 MHR Convertible Notes [Member]	Jun. 04, 2010 MHR Convertible Notes [Member]	Jun. 04, 2010 June 2010 MHR Warrants [Member]	Oct. 17, 2012 2012 Bridge Loan [Member]
Class of Warrant or Right [Line Items]
Shares of common stock																					8,353,518
Interest rate for MHR convertible notes																						13.00%				13.00%
Interest rate for MHR convertible notes																13.00%
Principal and interest due and payable																							$ 30,500,000
MHR convertible notes default description																					As of September 27, 2012, the Company is in default under the terms of the MHR Convertible Notes. The default is the result of the Company’s failure to pay MHR approximately $30.5 million in principal and interest due and payable on September 26, 2012 under the terms of the MHR Convertible Notes. As a result of the Company’s failure to pay all amounts due and payable under the MHR Convertible Notes as of September 26, 2012, MHR has the ability under the terms of our Security Agreement with MHR to foreclose on substantially all of the Company’s assets. On October 4, 2012, the Company received notice from MHR that, pursuant to the terms of the MHR Convertible Notes, the default interest rate of 13% per annum will apply with respect to the MHR Convertible Notes, effective as of September 27, 2012. MHR has not demanded payment under the MHR Convertible Notes nor exercised its other rights under the Security Agreement as a result of the default, and has continued discussions with the Company regarding proposals relating to the MHR Convertible Notes and the Company’s default thereunder while reserving all of its rights under the Security Agreement.
MHR convertible notes due date																Sep. 26, 2012
Total issuance costs associated with the loan agreement			1,858,000								500,000	1,400,000	1,900,000	200,000						2,100,000
Common stock																									865,000
Fair value of the June 2010 MHR Warrants by using Black-Scholes Model																									1,900,000
Fair value of the MHR Convertible Notes as of June 4, 2010		31,576,000			28,153,000																			17,200,000
Research collaboration and option agreement								11,000,000	11,000,000
Deposit liabilities, accrued interest								13,000,000	13,000,000
Legal fees																500,000	100,000
Non-interest promissory notes																500,000	100,000
Due date or expiry date		Jun. 04, 2012
Discounted value of the face amounts																		21,000	4,000
Secured loan amount from MHR							15,000,000			10,000,000																1,400,000
Amount of imputed interest															45,000
Notes Payable and Restructuring of Debt (Textual) [Abstract]
Net proceeds of secured loan agreement							12,900,000
Senior secured convertible notes loan agreement, execution date		May 16, 2006
Conversion price per share						$ 3.78
Reclassification of convertible notes into short term liability		Sep. 27, 2012
Minimum percentage of common stock outstanding to provide continuity to Mutual Nominee on Board		2.00%
Incremental borrowing rate		10.00%
Default of the aggregate reimbursement notes				600,000
Loss on extinguishment of debt	$ 17,000,000		$ (17,014,000)