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  <proxyTable>
    <issuerName>Priothera Limited</issuerName>
    <meetingDate>07/09/2024</meetingDate>
    <voteDescription>Approve Dec 31 2022 financial statements</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>CORPORATE GOVERNANCE</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>346666.000000</sharesVoted>
    <sharesOnLoan>0.000000</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>346666.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Priothera Limited</issuerName>
    <meetingDate>07/09/2024</meetingDate>
    <voteDescription>Re-appoint statutory auditors</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>AUDIT-RELATED</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>346666.000000</sharesVoted>
    <sharesOnLoan>0.000000</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>346666.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Priothera Limited</issuerName>
    <meetingDate>07/09/2024</meetingDate>
    <voteDescription>Authorize directors to approve remuneration of the statutory auditors for the calendar year 2023</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>AUDIT-RELATED</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>346666.000000</sharesVoted>
    <sharesOnLoan>0.000000</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>346666.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Jazz Pharmaceuticals plc</issuerName>
    <cusip>G50871105</cusip>
    <isin>IE00B4Q5ZN47</isin>
    <meetingDate>07/25/2024</meetingDate>
    <voteDescription>To elect four nominees for director named below to hold office until the 2027 Annual General Meeting of Shareholders: Laura J. Hamill</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>22124.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>22124.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Jazz Pharmaceuticals plc</issuerName>
    <cusip>G50871105</cusip>
    <isin>IE00B4Q5ZN47</isin>
    <meetingDate>07/25/2024</meetingDate>
    <voteDescription>To elect four nominees for director named below to hold office until the 2027 Annual General Meeting of Shareholders: Patrick Kennedy</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>22124.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>22124.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
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  <proxyTable>
    <issuerName>Jazz Pharmaceuticals plc</issuerName>
    <cusip>G50871105</cusip>
    <isin>IE00B4Q5ZN47</isin>
    <meetingDate>07/25/2024</meetingDate>
    <voteDescription>To elect four nominees for director named below to hold office until the 2027 Annual General Meeting of Shareholders: Kenneth W. O'Keefe</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>22124.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>22124.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Jazz Pharmaceuticals plc</issuerName>
    <cusip>G50871105</cusip>
    <isin>IE00B4Q5ZN47</isin>
    <meetingDate>07/25/2024</meetingDate>
    <voteDescription>To elect four nominees for director named below to hold office until the 2027 Annual General Meeting of Shareholders: Mark D. Smith, M.D.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>22124.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>22124.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
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    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Jazz Pharmaceuticals plc</issuerName>
    <cusip>G50871105</cusip>
    <isin>IE00B4Q5ZN47</isin>
    <meetingDate>07/25/2024</meetingDate>
    <voteDescription>To ratify, on a non-binding advisory basis, the appointment of KPMG as the independent auditors of Jazz Pharmaceuticals plc for the fiscal year ending December 31, 2024 and to authorize, in a binding vote, the Board of Directors, acting through the audit committee, to determine KPMG's remuneration.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>AUDIT-RELATED</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>22124.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>22124.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Jazz Pharmaceuticals plc</issuerName>
    <cusip>G50871105</cusip>
    <isin>IE00B4Q5ZN47</isin>
    <meetingDate>07/25/2024</meetingDate>
    <voteDescription>To approve, on a non-binding advisory basis, the compensation of Jazz Pharmaceuticals plc's named executive officers, as disclosed in the proxy statement.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>22124.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>AGAINST</howVoted>
        <sharesVoted>22124.000000</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Jazz Pharmaceuticals plc</issuerName>
    <cusip>G50871105</cusip>
    <isin>IE00B4Q5ZN47</isin>
    <meetingDate>07/25/2024</meetingDate>
    <voteDescription>To indicate, on a non-binding advisory basis, the preferred frequency of the advisory vote on the compensation of Jazz Pharmaceuticals plc's named executive officers.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>22124.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>ONE YEAR</howVoted>
        <sharesVoted>22124.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Jazz Pharmaceuticals plc</issuerName>
    <cusip>G50871105</cusip>
    <isin>IE00B4Q5ZN47</isin>
    <meetingDate>07/25/2024</meetingDate>
    <voteDescription>To grant the Board of Directors authority under Irish law to allot and issue ordinary shares for cash without first offering those ordinary shares to existing shareholders pursuant to the statutory pre-emption right that would otherwise apply.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>CAPITAL STRUCTURE</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>22124.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>AGAINST</howVoted>
        <sharesVoted>22124.000000</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Jazz Pharmaceuticals plc</issuerName>
    <cusip>G50871105</cusip>
    <isin>IE00B4Q5ZN47</isin>
    <meetingDate>07/25/2024</meetingDate>
    <voteDescription>To approve any motion to adjourn the Annual General Meeting, or any adjournments thereof, to another time and place to solicit additional proxies if there are insufficient votes at the time of the Annual General Meeting to approve Proposal 5.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>CORPORATE GOVERNANCE</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>22124.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>22124.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>McKesson Corporation</issuerName>
    <cusip>58155Q103</cusip>
    <isin>US58155Q1031</isin>
    <meetingDate>07/31/2024</meetingDate>
    <voteDescription>Election of eleven directors for a one-year term: Richard H. Carmona, M.D.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>12176.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>12176.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>McKesson Corporation</issuerName>
    <cusip>58155Q103</cusip>
    <isin>US58155Q1031</isin>
    <meetingDate>07/31/2024</meetingDate>
    <voteDescription>Election of eleven directors for a one-year term: Dominic J. Caruso</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>12176.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>12176.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>McKesson Corporation</issuerName>
    <cusip>58155Q103</cusip>
    <isin>US58155Q1031</isin>
    <meetingDate>07/31/2024</meetingDate>
    <voteDescription>Election of eleven directors for a one-year term: W. Roy Dunbar</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>12176.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>12176.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>McKesson Corporation</issuerName>
    <cusip>58155Q103</cusip>
    <isin>US58155Q1031</isin>
    <meetingDate>07/31/2024</meetingDate>
    <voteDescription>Election of eleven directors for a one-year term: Deborah Dunsire, M.D.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>12176.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>12176.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>McKesson Corporation</issuerName>
    <cusip>58155Q103</cusip>
    <isin>US58155Q1031</isin>
    <meetingDate>07/31/2024</meetingDate>
    <voteDescription>Election of eleven directors for a one-year term: James H. Hinton</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>12176.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>12176.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>McKesson Corporation</issuerName>
    <cusip>58155Q103</cusip>
    <isin>US58155Q1031</isin>
    <meetingDate>07/31/2024</meetingDate>
    <voteDescription>Election of eleven directors for a one-year term: Donald R. Knauss</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>12176.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>12176.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>McKesson Corporation</issuerName>
    <cusip>58155Q103</cusip>
    <isin>US58155Q1031</isin>
    <meetingDate>07/31/2024</meetingDate>
    <voteDescription>Election of eleven directors for a one-year term: Bradley E. Lerman</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>12176.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>12176.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>McKesson Corporation</issuerName>
    <cusip>58155Q103</cusip>
    <isin>US58155Q1031</isin>
    <meetingDate>07/31/2024</meetingDate>
    <voteDescription>Election of eleven directors for a one-year term: Maria N. Martinez</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>12176.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>12176.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>McKesson Corporation</issuerName>
    <cusip>58155Q103</cusip>
    <isin>US58155Q1031</isin>
    <meetingDate>07/31/2024</meetingDate>
    <voteDescription>Election of eleven directors for a one-year term: Kevin M. Ozan</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>12176.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>12176.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>McKesson Corporation</issuerName>
    <cusip>58155Q103</cusip>
    <isin>US58155Q1031</isin>
    <meetingDate>07/31/2024</meetingDate>
    <voteDescription>Election of eleven directors for a one-year term: Brian S. Tyler</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>12176.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>12176.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
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    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>McKesson Corporation</issuerName>
    <cusip>58155Q103</cusip>
    <isin>US58155Q1031</isin>
    <meetingDate>07/31/2024</meetingDate>
    <voteDescription>Election of eleven directors for a one-year term: Kathleen Wilson-Thompson</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>12176.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>12176.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>McKesson Corporation</issuerName>
    <cusip>58155Q103</cusip>
    <isin>US58155Q1031</isin>
    <meetingDate>07/31/2024</meetingDate>
    <voteDescription>Ratification of Appointment of Deloitte &amp; Touche LLP as the Company's Independent Registered Public Accounting Firm for Fiscal Year 2025</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>AUDIT-RELATED</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>12176.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>AGAINST</howVoted>
        <sharesVoted>12176.000000</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>McKesson Corporation</issuerName>
    <cusip>58155Q103</cusip>
    <isin>US58155Q1031</isin>
    <meetingDate>07/31/2024</meetingDate>
    <voteDescription>Advisory vote on Executive Compensation</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>12176.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>AGAINST</howVoted>
        <sharesVoted>12176.000000</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>McKesson Corporation</issuerName>
    <cusip>58155Q103</cusip>
    <isin>US58155Q1031</isin>
    <meetingDate>07/31/2024</meetingDate>
    <voteDescription>Approve Amendment to Certificate of Incorporation to Provide for Officer Exculpation</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>CORPORATE GOVERNANCE</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>12176.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>12176.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>McKesson Corporation</issuerName>
    <cusip>58155Q103</cusip>
    <isin>US58155Q1031</isin>
    <meetingDate>07/31/2024</meetingDate>
    <voteDescription>Shareholder Proposal on Independent Board Chairman</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>CORPORATE GOVERNANCE</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>SECURITY HOLDER</voteSource>
    <sharesVoted>12176.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>12176.000000</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>McKesson Corporation</issuerName>
    <cusip>58155Q103</cusip>
    <isin>US58155Q1031</isin>
    <meetingDate>07/31/2024</meetingDate>
    <voteDescription>Shareholder Proposal on Report on Risks of State Policies Restricting Reproductive Health Care</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>OTHER SOCIAL ISSUES</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>SECURITY HOLDER</voteSource>
    <sharesVoted>12176.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>AGAINST</howVoted>
        <sharesVoted>12176.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Immunovant, Inc.</issuerName>
    <cusip>45258J102</cusip>
    <isin>US45258J1025</isin>
    <meetingDate>08/12/2024</meetingDate>
    <voteDescription>To elect as directors the three nominees named in the Company's proxy statement, each to hold office until our 2025 Annual Meeting of Stockholders and until their successors are duly elected and qualified: Peter Salzmann, M.D., M.B.A.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>263613.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>WITHHOLD</howVoted>
        <sharesVoted>263613.000000</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Immunovant, Inc.</issuerName>
    <cusip>45258J102</cusip>
    <isin>US45258J1025</isin>
    <meetingDate>08/12/2024</meetingDate>
    <voteDescription>To elect as directors the three nominees named in the Company's proxy statement, each to hold office until our 2025 Annual Meeting of Stockholders and until their successors are duly elected and qualified: George Migausky</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>263613.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>WITHHOLD</howVoted>
        <sharesVoted>263613.000000</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Immunovant, Inc.</issuerName>
    <cusip>45258J102</cusip>
    <isin>US45258J1025</isin>
    <meetingDate>08/12/2024</meetingDate>
    <voteDescription>To elect as directors the three nominees named in the Company's proxy statement, each to hold office until our 2025 Annual Meeting of Stockholders and until their successors are duly elected and qualified: Douglas Hughes</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>263613.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>WITHHOLD</howVoted>
        <sharesVoted>263613.000000</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Immunovant, Inc.</issuerName>
    <cusip>45258J102</cusip>
    <isin>US45258J1025</isin>
    <meetingDate>08/12/2024</meetingDate>
    <voteDescription>To ratify the selection by the Audit Committee of the Board of Directors of Ernst &amp; Young LLP as our independent registered public accounting firm for the fiscal year ending March 31, 2025.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>AUDIT-RELATED</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>263613.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>263613.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Immunovant, Inc.</issuerName>
    <cusip>45258J102</cusip>
    <isin>US45258J1025</isin>
    <meetingDate>08/12/2024</meetingDate>
    <voteDescription>To approve, on a non-binding, advisory basis, the compensation of our named executive officers.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>263613.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>263613.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Roivant Sciences Ltd.</issuerName>
    <cusip>G76279101</cusip>
    <isin>BMG762791017</isin>
    <meetingDate>09/10/2024</meetingDate>
    <voteDescription>To elect the Board of Directors' three nominees for Class III Director to serve for a three-year term: Ilan Oren</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>747277.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>WITHHOLD</howVoted>
        <sharesVoted>747277.000000</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Roivant Sciences Ltd.</issuerName>
    <cusip>G76279101</cusip>
    <isin>BMG762791017</isin>
    <meetingDate>09/10/2024</meetingDate>
    <voteDescription>To elect the Board of Directors' three nominees for Class III Director to serve for a three-year term: James C. Momtazee</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>747277.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>WITHHOLD</howVoted>
        <sharesVoted>747277.000000</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Roivant Sciences Ltd.</issuerName>
    <cusip>G76279101</cusip>
    <isin>BMG762791017</isin>
    <meetingDate>09/10/2024</meetingDate>
    <voteDescription>To elect the Board of Directors' three nominees for Class III Director to serve for a three-year term: Mayukh Sukhatme</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>747277.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>747277.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Roivant Sciences Ltd.</issuerName>
    <cusip>G76279101</cusip>
    <isin>BMG762791017</isin>
    <meetingDate>09/10/2024</meetingDate>
    <voteDescription>To ratify the selection by the Audit Committee of the Board of Directors of Ernst &amp; Young LLP as Roivant's independent registered public accounting firm for Roivant's fiscal year ending March 31, 2025, to appoint Ernst &amp; Young LLP as auditor for statutory purposes under the Bermuda Companies Act 1981, as amended, for Roivant's fiscal year ending March 31, 2025, and to authorize the Board of Directors, through the Audit Committee, to set the remuneration for Ernst &amp; Young LLP as Roivant's auditor for Roivant's fiscal year ending March 31, 2025.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>AUDIT-RELATED</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>747277.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>747277.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Roivant Sciences Ltd.</issuerName>
    <cusip>G76279101</cusip>
    <isin>BMG762791017</isin>
    <meetingDate>09/10/2024</meetingDate>
    <voteDescription>To cast a non-binding, advisory vote to approve the compensation of our named executive officers.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>747277.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>747277.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Roivant Sciences Ltd.</issuerName>
    <cusip>G76279101</cusip>
    <isin>BMG762791017</isin>
    <meetingDate>09/10/2024</meetingDate>
    <voteDescription>To cast a non-binding, advisory vote on the frequency of future non-binding, advisory votes to approve the compensation of our named executive officers every:</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>747277.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>ONE YEAR</howVoted>
        <sharesVoted>747277.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Rhythm Pharmaceuticals, Inc.</issuerName>
    <cusip>76243J105</cusip>
    <isin>US76243J1051</isin>
    <meetingDate>09/18/2024</meetingDate>
    <voteDescription>Election of the Class I directors, each to serve for a three year term until the 2027 Annual Meeting of Stockholders and until their respective successors are duly elected and qualified: Stuart A. Arbuckle</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>74675.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>WITHHOLD</howVoted>
        <sharesVoted>74675.000000</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Rhythm Pharmaceuticals, Inc.</issuerName>
    <cusip>76243J105</cusip>
    <isin>US76243J1051</isin>
    <meetingDate>09/18/2024</meetingDate>
    <voteDescription>Election of the Class I directors, each to serve for a three year term until the 2027 Annual Meeting of Stockholders and until their respective successors are duly elected and qualified: Christophe R. Jean</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>74675.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>WITHHOLD</howVoted>
        <sharesVoted>74675.000000</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Rhythm Pharmaceuticals, Inc.</issuerName>
    <cusip>76243J105</cusip>
    <isin>US76243J1051</isin>
    <meetingDate>09/18/2024</meetingDate>
    <voteDescription>Election of the Class I directors, each to serve for a three year term until the 2027 Annual Meeting of Stockholders and until their respective successors are duly elected and qualified: Lynn A. Tetrault</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>74675.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>WITHHOLD</howVoted>
        <sharesVoted>74675.000000</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Rhythm Pharmaceuticals, Inc.</issuerName>
    <cusip>76243J105</cusip>
    <isin>US76243J1051</isin>
    <meetingDate>09/18/2024</meetingDate>
    <voteDescription>Ratification of the appointment of Ernst &amp; Young LLP as the independent registered public accounting firm for the Company for the fiscal year ending December 31, 2024.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>AUDIT-RELATED</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>74675.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>74675.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Rhythm Pharmaceuticals, Inc.</issuerName>
    <cusip>76243J105</cusip>
    <isin>US76243J1051</isin>
    <meetingDate>09/18/2024</meetingDate>
    <voteDescription>Approval, on an advisory (non-binding) basis, of the compensation of the named executive officers of the Company.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>74675.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>74675.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Rhythm Pharmaceuticals, Inc.</issuerName>
    <cusip>76243J105</cusip>
    <isin>US76243J1051</isin>
    <meetingDate>09/18/2024</meetingDate>
    <voteDescription>Reapproval of the Rhythm Pharmaceuticals, Inc. 2017 Equity Incentive Plan.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>COMPENSATION</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>74675.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>AGAINST</howVoted>
        <sharesVoted>74675.000000</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Galera Therapeutics, Inc.</issuerName>
    <cusip>36338D108</cusip>
    <isin>US36338D1081</isin>
    <meetingDate>10/17/2024</meetingDate>
    <voteDescription>To approve the liquidation and dissolution of the Company and the Plan of Liquidation and Dissolution (the &quot;Plan of Dissolution&quot;) which, if approved, will authorize the Company's Board of Directors to liquidate and dissolve the Company in accordance with the Plan of Dissolution (the &quot;Dissolution Proposal&quot;).</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>EXTRAORDINARY TRANSACTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>296462.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>296462.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Galera Therapeutics, Inc.</issuerName>
    <cusip>36338D108</cusip>
    <isin>US36338D1081</isin>
    <meetingDate>10/17/2024</meetingDate>
    <voteDescription>To adjourn the Special Meeting, from time to time, to a later date or dates, even if a quorum is present, to solicit additional proxies in the event that there are not sufficient votes at the time of the Special Meeting to approve the Dissolution Proposal.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>CORPORATE GOVERNANCE</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>296462.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>296462.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Medtronic Plc</issuerName>
    <cusip>G5960L103</cusip>
    <isin>IE00BTN1Y115</isin>
    <meetingDate>10/17/2024</meetingDate>
    <voteDescription>Electing, by separate resolutions, the ten director nominees named in the proxy statement to hold office until the 2025 Annual General Meeting of Medtronic plc (the &quot;Company&quot;): Craig Arnold</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>52381.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>52381.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Medtronic Plc</issuerName>
    <cusip>G5960L103</cusip>
    <isin>IE00BTN1Y115</isin>
    <meetingDate>10/17/2024</meetingDate>
    <voteDescription>Electing, by separate resolutions, the ten director nominees named in the proxy statement to hold office until the 2025 Annual General Meeting of Medtronic plc (the &quot;Company&quot;): Scott C. Donnelly</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>52381.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>52381.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Medtronic Plc</issuerName>
    <cusip>G5960L103</cusip>
    <isin>IE00BTN1Y115</isin>
    <meetingDate>10/17/2024</meetingDate>
    <voteDescription>Electing, by separate resolutions, the ten director nominees named in the proxy statement to hold office until the 2025 Annual General Meeting of Medtronic plc (the &quot;Company&quot;): Lidia L. Fonseca</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>52381.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>52381.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Medtronic Plc</issuerName>
    <cusip>G5960L103</cusip>
    <isin>IE00BTN1Y115</isin>
    <meetingDate>10/17/2024</meetingDate>
    <voteDescription>Electing, by separate resolutions, the ten director nominees named in the proxy statement to hold office until the 2025 Annual General Meeting of Medtronic plc (the &quot;Company&quot;): Andrea J. Goldsmith, Ph.D.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>52381.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>52381.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Medtronic Plc</issuerName>
    <cusip>G5960L103</cusip>
    <isin>IE00BTN1Y115</isin>
    <meetingDate>10/17/2024</meetingDate>
    <voteDescription>Electing, by separate resolutions, the ten director nominees named in the proxy statement to hold office until the 2025 Annual General Meeting of Medtronic plc (the &quot;Company&quot;): Randall J. Hogan, III</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>52381.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>52381.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Medtronic Plc</issuerName>
    <cusip>G5960L103</cusip>
    <isin>IE00BTN1Y115</isin>
    <meetingDate>10/17/2024</meetingDate>
    <voteDescription>Electing, by separate resolutions, the ten director nominees named in the proxy statement to hold office until the 2025 Annual General Meeting of Medtronic plc (the &quot;Company&quot;): Gregory P. Lewis</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>52381.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>52381.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Medtronic Plc</issuerName>
    <cusip>G5960L103</cusip>
    <isin>IE00BTN1Y115</isin>
    <meetingDate>10/17/2024</meetingDate>
    <voteDescription>Electing, by separate resolutions, the ten director nominees named in the proxy statement to hold office until the 2025 Annual General Meeting of Medtronic plc (the &quot;Company&quot;): Kevin E. Lofton</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>52381.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>52381.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Medtronic Plc</issuerName>
    <cusip>G5960L103</cusip>
    <isin>IE00BTN1Y115</isin>
    <meetingDate>10/17/2024</meetingDate>
    <voteDescription>Electing, by separate resolutions, the ten director nominees named in the proxy statement to hold office until the 2025 Annual General Meeting of Medtronic plc (the &quot;Company&quot;): Geoffrey S. Martha</voteDescription>
    <voteCategories>
      <voteCategory>
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    <voteDescription>To elect the thirteen directors named in the attached Proxy Statement to hold office until the 2026 Annual Meeting of Shareholders and until their successors are elected and qualified: Raymond C. Stevens, Ph.D.</voteDescription>
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    <cusip>02043Q107</cusip>
    <isin>US02043Q1076</isin>
    <meetingDate>05/08/2025</meetingDate>
    <voteDescription>To elect the following nominees as Class III directors of Alnylam: Carolyn R. Bertozzi, Ph.D.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>104848.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>104848.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Alnylam Pharmaceuticals, Inc.</issuerName>
    <cusip>02043Q107</cusip>
    <isin>US02043Q1076</isin>
    <meetingDate>05/08/2025</meetingDate>
    <voteDescription>To elect the following nominees as Class III directors of Alnylam: Margaret A. Hamburg, M.D.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>104848.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>104848.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Alnylam Pharmaceuticals, Inc.</issuerName>
    <cusip>02043Q107</cusip>
    <isin>US02043Q1076</isin>
    <meetingDate>05/08/2025</meetingDate>
    <voteDescription>To elect the following nominees as Class III directors of Alnylam: Colleen F. Reitan</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>104848.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>104848.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Alnylam Pharmaceuticals, Inc.</issuerName>
    <cusip>02043Q107</cusip>
    <isin>US02043Q1076</isin>
    <meetingDate>05/08/2025</meetingDate>
    <voteDescription>To elect the following nominees as Class III directors of Alnylam: Amy W. Schulman</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>104848.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>104848.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Alnylam Pharmaceuticals, Inc.</issuerName>
    <cusip>02043Q107</cusip>
    <isin>US02043Q1076</isin>
    <meetingDate>05/08/2025</meetingDate>
    <voteDescription>To approve an Amendment to our Restated Certificate of Incorporation allowing for officer exculpation.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>CORPORATE GOVERNANCE</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>104848.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>104848.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Alnylam Pharmaceuticals, Inc.</issuerName>
    <cusip>02043Q107</cusip>
    <isin>US02043Q1076</isin>
    <meetingDate>05/08/2025</meetingDate>
    <voteDescription>To approve the second amended and restated 2018 Stock Incentive Plan.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>COMPENSATION</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>104848.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>104848.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Alnylam Pharmaceuticals, Inc.</issuerName>
    <cusip>02043Q107</cusip>
    <isin>US02043Q1076</isin>
    <meetingDate>05/08/2025</meetingDate>
    <voteDescription>To approve, in a non-binding advisory vote, the compensation of Alnylam's named executive officers.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>104848.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>AGAINST</howVoted>
        <sharesVoted>104848.000000</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Alnylam Pharmaceuticals, Inc.</issuerName>
    <cusip>02043Q107</cusip>
    <isin>US02043Q1076</isin>
    <meetingDate>05/08/2025</meetingDate>
    <voteDescription>To ratify the appointment of PricewaterhouseCoopers LLP, an independent registered public accounting firm, as Alnylam's independent auditors for the fiscal year ending December 31, 2025.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>AUDIT-RELATED</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>104848.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>AGAINST</howVoted>
        <sharesVoted>104848.000000</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>DexCom, Inc.</issuerName>
    <cusip>252131107</cusip>
    <isin>US2521311074</isin>
    <meetingDate>05/08/2025</meetingDate>
    <voteDescription>To elect ten nominees for director, each to hold office until our 2026 annual meeting of stockholders: Kevin R. Sayer</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>64933.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>64933.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>DexCom, Inc.</issuerName>
    <cusip>252131107</cusip>
    <isin>US2521311074</isin>
    <meetingDate>05/08/2025</meetingDate>
    <voteDescription>To elect ten nominees for director, each to hold office until our 2026 annual meeting of stockholders: Steven R. Altman</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>64933.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>64933.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>DexCom, Inc.</issuerName>
    <cusip>252131107</cusip>
    <isin>US2521311074</isin>
    <meetingDate>05/08/2025</meetingDate>
    <voteDescription>To elect ten nominees for director, each to hold office until our 2026 annual meeting of stockholders: Nicholas Augustinos</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>64933.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>64933.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>DexCom, Inc.</issuerName>
    <cusip>252131107</cusip>
    <isin>US2521311074</isin>
    <meetingDate>05/08/2025</meetingDate>
    <voteDescription>To elect ten nominees for director, each to hold office until our 2026 annual meeting of stockholders: Richard A. Collins</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>64933.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>64933.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>DexCom, Inc.</issuerName>
    <cusip>252131107</cusip>
    <isin>US2521311074</isin>
    <meetingDate>05/08/2025</meetingDate>
    <voteDescription>To elect ten nominees for director, each to hold office until our 2026 annual meeting of stockholders: Rimma Driscoll</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>64933.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>64933.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>DexCom, Inc.</issuerName>
    <cusip>252131107</cusip>
    <isin>US2521311074</isin>
    <meetingDate>05/08/2025</meetingDate>
    <voteDescription>To elect ten nominees for director, each to hold office until our 2026 annual meeting of stockholders: Mark G. Foletta</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>64933.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>64933.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>DexCom, Inc.</issuerName>
    <cusip>252131107</cusip>
    <isin>US2521311074</isin>
    <meetingDate>05/08/2025</meetingDate>
    <voteDescription>To elect ten nominees for director, each to hold office until our 2026 annual meeting of stockholders: Renee Gala</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>64933.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>64933.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>DexCom, Inc.</issuerName>
    <cusip>252131107</cusip>
    <isin>US2521311074</isin>
    <meetingDate>05/08/2025</meetingDate>
    <voteDescription>To elect ten nominees for director, each to hold office until our 2026 annual meeting of stockholders: Bridgette P. Heller</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>64933.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>64933.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>DexCom, Inc.</issuerName>
    <cusip>252131107</cusip>
    <isin>US2521311074</isin>
    <meetingDate>05/08/2025</meetingDate>
    <voteDescription>To elect ten nominees for director, each to hold office until our 2026 annual meeting of stockholders: Kyle Malady</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>64933.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>64933.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>DexCom, Inc.</issuerName>
    <cusip>252131107</cusip>
    <isin>US2521311074</isin>
    <meetingDate>05/08/2025</meetingDate>
    <voteDescription>To ratify the selection by the Audit Committee of our Board of Directors of Deloitte &amp; Touche LLP as our independent registered public accounting firm for the fiscal year ending December 31, 2025.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>AUDIT-RELATED</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>64933.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>64933.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>DexCom, Inc.</issuerName>
    <cusip>252131107</cusip>
    <isin>US2521311074</isin>
    <meetingDate>05/08/2025</meetingDate>
    <voteDescription>To provide a non-binding advisory vote on the compensation of our named executive officers for the fiscal year ended December 31, 2024.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>64933.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>AGAINST</howVoted>
        <sharesVoted>64933.000000</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>DexCom, Inc.</issuerName>
    <cusip>252131107</cusip>
    <isin>US2521311074</isin>
    <meetingDate>05/08/2025</meetingDate>
    <voteDescription>To approve our Amended and Restated 2015 Equity Incentive Plan (as amended and restated) to, among other things, increase the number of shares reserved for issuance thereunder by 3,400,000 shares.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>COMPENSATION</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>64933.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>64933.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>DexCom, Inc.</issuerName>
    <cusip>252131107</cusip>
    <isin>US2521311074</isin>
    <meetingDate>05/08/2025</meetingDate>
    <voteDescription>To approve our Amended and Restated 2015 Employee Stock Purchase Plan to, among other things, increase the number of shares reserved for issuance thereunder by 8,000,000 shares.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>COMPENSATION</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>64933.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>64933.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Stryker Corporation</issuerName>
    <cusip>863667101</cusip>
    <isin>US8636671013</isin>
    <meetingDate>05/08/2025</meetingDate>
    <voteDescription>Election of Ten Directors: Mary K. Brainerd</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>5969.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>5969.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Stryker Corporation</issuerName>
    <cusip>863667101</cusip>
    <isin>US8636671013</isin>
    <meetingDate>05/08/2025</meetingDate>
    <voteDescription>Election of Ten Directors: Giovanni Caforio, M.D.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>5969.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>5969.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Stryker Corporation</issuerName>
    <cusip>863667101</cusip>
    <isin>US8636671013</isin>
    <meetingDate>05/08/2025</meetingDate>
    <voteDescription>Election of Ten Directors: Kevin A. Lobo</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>5969.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>5969.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Stryker Corporation</issuerName>
    <cusip>863667101</cusip>
    <isin>US8636671013</isin>
    <meetingDate>05/08/2025</meetingDate>
    <voteDescription>Election of Ten Directors: Emmanuel P. Maceda</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>5969.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>5969.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Stryker Corporation</issuerName>
    <cusip>863667101</cusip>
    <isin>US8636671013</isin>
    <meetingDate>05/08/2025</meetingDate>
    <voteDescription>Election of Ten Directors: Sherilyn S. McCoy</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>5969.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>5969.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Stryker Corporation</issuerName>
    <cusip>863667101</cusip>
    <isin>US8636671013</isin>
    <meetingDate>05/08/2025</meetingDate>
    <voteDescription>Election of Ten Directors: Rachel M. Ruggeri</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>5969.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>5969.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Stryker Corporation</issuerName>
    <cusip>863667101</cusip>
    <isin>US8636671013</isin>
    <meetingDate>05/08/2025</meetingDate>
    <voteDescription>Election of Ten Directors: Andrew K. Silvernail</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>5969.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>5969.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Stryker Corporation</issuerName>
    <cusip>863667101</cusip>
    <isin>US8636671013</isin>
    <meetingDate>05/08/2025</meetingDate>
    <voteDescription>Election of Ten Directors: Lisa M. Skeete Tatum</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
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    <isin>US89422G1076</isin>
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    <voteDescription>To elect each of the Board's ten nominees for director named in the accompanying proxy statement to serve for a term of one year: John Orwin</voteDescription>
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      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
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    <voteSource>ISSUER</voteSource>
    <sharesVoted>276167.000000</sharesVoted>
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        <sharesVoted>276167.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
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    <issuerName>Travere Therapeutics, Inc.</issuerName>
    <cusip>89422G107</cusip>
    <isin>US89422G1076</isin>
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    <voteDescription>To elect each of the Board's ten nominees for director named in the accompanying proxy statement to serve for a term of one year: Sandra Poole</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
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    <voteSource>ISSUER</voteSource>
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        <sharesVoted>276167.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
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    <issuerName>Travere Therapeutics, Inc.</issuerName>
    <cusip>89422G107</cusip>
    <isin>US89422G1076</isin>
    <meetingDate>05/15/2025</meetingDate>
    <voteDescription>To elect each of the Board's ten nominees for director named in the accompanying proxy statement to serve for a term of one year: Ron Squarer</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
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    <voteSource>ISSUER</voteSource>
    <sharesVoted>276167.000000</sharesVoted>
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        <sharesVoted>276167.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
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    <issuerName>Travere Therapeutics, Inc.</issuerName>
    <cusip>89422G107</cusip>
    <isin>US89422G1076</isin>
    <meetingDate>05/15/2025</meetingDate>
    <voteDescription>To elect each of the Board's ten nominees for director named in the accompanying proxy statement to serve for a term of one year: Ruth Williams-Brinkley</voteDescription>
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      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
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    <voteSource>ISSUER</voteSource>
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        <managementRecommendation>FOR</managementRecommendation>
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    <isin>US89422G1076</isin>
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    <voteDescription>To approve the Company's 2018 Equity Incentive Plan, as amended, to increase the number of shares of common stock authorized for issuance thereunder by 4,000,000 shares.</voteDescription>
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      <voteCategory>
        <categoryType>COMPENSATION</categoryType>
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    <voteSource>ISSUER</voteSource>
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        <sharesVoted>276167.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
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    <isin>US89422G1076</isin>
    <meetingDate>05/15/2025</meetingDate>
    <voteDescription>To approve, on an advisory basis, the compensation of the Company's named executive officers.</voteDescription>
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      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
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        <sharesVoted>276167.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
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    <cusip>89422G107</cusip>
    <isin>US89422G1076</isin>
    <meetingDate>05/15/2025</meetingDate>
    <voteDescription>To ratify the selection of Ernst &amp; Young LLP as the independent registered public accounting firm of the Company for its fiscal year ending December 31, 2025.</voteDescription>
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      <voteCategory>
        <categoryType>AUDIT-RELATED</categoryType>
      </voteCategory>
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    <voteSource>ISSUER</voteSource>
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    <vote>
      <voteRecord>
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        <sharesVoted>276167.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
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    <cusip>90400D108</cusip>
    <isin>US90400D1081</isin>
    <meetingDate>05/15/2025</meetingDate>
    <voteDescription>Nominees: Matthew K. Fust</voteDescription>
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      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>297732.000000</sharesVoted>
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    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>297732.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
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    <issuerName>Ultragenyx Pharmaceutical Inc.</issuerName>
    <cusip>90400D108</cusip>
    <isin>US90400D1081</isin>
    <meetingDate>05/15/2025</meetingDate>
    <voteDescription>Nominees: Amrit Ray, M.D.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>297732.000000</sharesVoted>
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    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>297732.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
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    <issuerName>Ultragenyx Pharmaceutical Inc.</issuerName>
    <cusip>90400D108</cusip>
    <isin>US90400D1081</isin>
    <meetingDate>05/15/2025</meetingDate>
    <voteDescription>Approval of the Second Amended and Restated 2023 Incentive Plan.</voteDescription>
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      <voteCategory>
        <categoryType>COMPENSATION</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>297732.000000</sharesVoted>
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    <vote>
      <voteRecord>
        <howVoted>AGAINST</howVoted>
        <sharesVoted>297732.000000</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
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    </vote>
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    <issuerName>Ultragenyx Pharmaceutical Inc.</issuerName>
    <cusip>90400D108</cusip>
    <isin>US90400D1081</isin>
    <meetingDate>05/15/2025</meetingDate>
    <voteDescription>Ratification of the selection of Ernst &amp; Young LLP as our independent registered public accounting firm for the fiscal year ending December 31, 2025.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>AUDIT-RELATED</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>297732.000000</sharesVoted>
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    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>297732.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Ultragenyx Pharmaceutical Inc.</issuerName>
    <cusip>90400D108</cusip>
    <isin>US90400D1081</isin>
    <meetingDate>05/15/2025</meetingDate>
    <voteDescription>Advisory (non-binding) vote to approve the compensation of our named executive officers.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>297732.000000</sharesVoted>
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    <vote>
      <voteRecord>
        <howVoted>AGAINST</howVoted>
        <sharesVoted>297732.000000</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
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    <issuerName>BioNTech SE</issuerName>
    <cusip>09075V102</cusip>
    <isin>US09075V1026</isin>
    <meetingDate>05/16/2025</meetingDate>
    <voteDescription>Approve Allocation of Income and Omission of Dividends</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>CAPITAL STRUCTURE</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>211403.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>211403.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>BioNTech SE</issuerName>
    <cusip>09075V102</cusip>
    <isin>US09075V1026</isin>
    <meetingDate>05/16/2025</meetingDate>
    <voteDescription>Approve Discharge of Management Board for Fiscal Year 2024</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>CORPORATE GOVERNANCE</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>211403.000000</sharesVoted>
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    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>211403.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>BioNTech SE</issuerName>
    <cusip>09075V102</cusip>
    <isin>US09075V1026</isin>
    <meetingDate>05/16/2025</meetingDate>
    <voteDescription>Approve Discharge of Supervisory Board for Fiscal Year 2024</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>CORPORATE GOVERNANCE</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>211403.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>211403.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>BioNTech SE</issuerName>
    <cusip>09075V102</cusip>
    <isin>US09075V1026</isin>
    <meetingDate>05/16/2025</meetingDate>
    <voteDescription>Ratify EY GmbH &amp; Co. KG as Auditors for Fiscal Year 2025</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>AUDIT-RELATED</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>211403.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>211403.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>BioNTech SE</issuerName>
    <cusip>09075V102</cusip>
    <isin>US09075V1026</isin>
    <meetingDate>05/16/2025</meetingDate>
    <voteDescription>Appoint EY GmbH &amp; Co. KG as Auditor for Sustainability Reporting for Fiscal Year 2025</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>AUDIT-RELATED</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>211403.000000</sharesVoted>
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    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>211403.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>BioNTech SE</issuerName>
    <cusip>09075V102</cusip>
    <isin>US09075V1026</isin>
    <meetingDate>05/16/2025</meetingDate>
    <voteDescription>Approve Remuneration Report</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>COMPENSATION</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>211403.000000</sharesVoted>
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    <vote>
      <voteRecord>
        <howVoted>AGAINST</howVoted>
        <sharesVoted>211403.000000</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
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  <proxyTable>
    <issuerName>BioNTech SE</issuerName>
    <cusip>09075V102</cusip>
    <isin>US09075V1026</isin>
    <meetingDate>05/16/2025</meetingDate>
    <voteDescription>Approve Creation of EUR 124.3 Million Pool of Authorized Capital with or without Exclusion of Preemptive Rights</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>CAPITAL STRUCTURE</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>211403.000000</sharesVoted>
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    <vote>
      <voteRecord>
        <howVoted>AGAINST</howVoted>
        <sharesVoted>211403.000000</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Krystal Biotech, Inc.</issuerName>
    <cusip>501147102</cusip>
    <isin>US5011471027</isin>
    <meetingDate>05/16/2025</meetingDate>
    <voteDescription>Election of Class II Directors: Daniel S. Janney</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>38460.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>WITHHOLD</howVoted>
        <sharesVoted>38460.000000</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Krystal Biotech, Inc.</issuerName>
    <cusip>501147102</cusip>
    <isin>US5011471027</isin>
    <meetingDate>05/16/2025</meetingDate>
    <voteDescription>Election of Class II Directors: Dino A. Rossi</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>38460.000000</sharesVoted>
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    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>38460.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
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    </vote>
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  <proxyTable>
    <issuerName>Krystal Biotech, Inc.</issuerName>
    <cusip>501147102</cusip>
    <isin>US5011471027</isin>
    <meetingDate>05/16/2025</meetingDate>
    <voteDescription>Election of Class II Directors: E. Rand Sutherland</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
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    <voteSource>ISSUER</voteSource>
    <sharesVoted>38460.000000</sharesVoted>
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    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>38460.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
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    </vote>
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  <proxyTable>
    <issuerName>Krystal Biotech, Inc.</issuerName>
    <cusip>501147102</cusip>
    <isin>US5011471027</isin>
    <meetingDate>05/16/2025</meetingDate>
    <voteDescription>To ratify the appointment of KPMG LLP as our independent registered public accounting firm for our fiscal year ending December 31, 2025.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>AUDIT-RELATED</categoryType>
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    <voteSource>ISSUER</voteSource>
    <sharesVoted>38460.000000</sharesVoted>
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    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>38460.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
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  <proxyTable>
    <issuerName>Krystal Biotech, Inc.</issuerName>
    <cusip>501147102</cusip>
    <isin>US5011471027</isin>
    <meetingDate>05/16/2025</meetingDate>
    <voteDescription>Approval of the compensation of the Company's named executive officers, on a non-binding, advisory basis.</voteDescription>
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      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
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    <voteSource>ISSUER</voteSource>
    <sharesVoted>38460.000000</sharesVoted>
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    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>38460.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
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  <proxyTable>
    <issuerName>Medpace Holdings, Inc.</issuerName>
    <cusip>58506Q109</cusip>
    <isin>US58506Q1094</isin>
    <meetingDate>05/16/2025</meetingDate>
    <voteDescription>Election of Directors: August J. Troendle</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>15401.000000</sharesVoted>
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    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>15401.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
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  <proxyTable>
    <issuerName>Medpace Holdings, Inc.</issuerName>
    <cusip>58506Q109</cusip>
    <isin>US58506Q1094</isin>
    <meetingDate>05/16/2025</meetingDate>
    <voteDescription>Election of Directors: Dani S. Zander</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
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    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>15401.000000</sharesVoted>
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    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>15401.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
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    </vote>
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  <proxyTable>
    <issuerName>Medpace Holdings, Inc.</issuerName>
    <cusip>58506Q109</cusip>
    <isin>US58506Q1094</isin>
    <meetingDate>05/16/2025</meetingDate>
    <voteDescription>To ratify the appointment of Deloitte &amp; Touche LLP as our independent registered public accounting firm for the fiscal year ending December 31, 2025.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>AUDIT-RELATED</categoryType>
      </voteCategory>
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    <voteSource>ISSUER</voteSource>
    <sharesVoted>15401.000000</sharesVoted>
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    <vote>
      <voteRecord>
        <howVoted>AGAINST</howVoted>
        <sharesVoted>15401.000000</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
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  <proxyTable>
    <issuerName>Medpace Holdings, Inc.</issuerName>
    <cusip>58506Q109</cusip>
    <isin>US58506Q1094</isin>
    <meetingDate>05/16/2025</meetingDate>
    <voteDescription>To approve, on an advisory basis, the compensation of our named executive officers as disclosed in the proxy statement for the 2025 Annual Meeting.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
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    <voteSource>ISSUER</voteSource>
    <sharesVoted>15401.000000</sharesVoted>
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    <vote>
      <voteRecord>
        <howVoted>AGAINST</howVoted>
        <sharesVoted>15401.000000</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
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  <proxyTable>
    <issuerName>Medpace Holdings, Inc.</issuerName>
    <cusip>58506Q109</cusip>
    <isin>US58506Q1094</isin>
    <meetingDate>05/16/2025</meetingDate>
    <voteDescription>To approve the Medpace Holdings, Inc. 2016 Amended and Restated Incentive Award Plan.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>COMPENSATION</categoryType>
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    <voteDescription>Election of Directors: Elizabeth M. Anderson</voteDescription>
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    <voteDescription>Election of Directors: Timothy P. Walbert</voteDescription>
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      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
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    <voteDescription>To ratify the selection of KPMG LLP as the independent registered public accounting firm for the Company for the fiscal year ending December 31, 2025.</voteDescription>
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      <voteCategory>
        <categoryType>AUDIT-RELATED</categoryType>
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    <voteDescription>To approve, on an advisory basis, the compensation of the Company's Named Executive Officers as disclosed in the Proxy Statement.</voteDescription>
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        <managementRecommendation>FOR</managementRecommendation>
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    <voteDescription>To approve an amendment to the Company's 2017 Equity Incentive Plan, as amended.</voteDescription>
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      <voteCategory>
        <categoryType>COMPENSATION</categoryType>
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        <managementRecommendation>FOR</managementRecommendation>
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    <voteDescription>To elect nine directors to serve until the next annual meeting and their successors are duly elected and qualified, or until their earlier death, resignation or removal: Eric Lefkofsky</voteDescription>
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      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
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    <voteSource>ISSUER</voteSource>
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        <sharesVoted>193691.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
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    <voteDescription>To elect nine directors to serve until the next annual meeting and their successors are duly elected and qualified, or until their earlier death, resignation or removal: Peter J. Barris</voteDescription>
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      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
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        <sharesVoted>193691.000000</sharesVoted>
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    <voteDescription>To elect nine directors to serve until the next annual meeting and their successors are duly elected and qualified, or until their earlier death, resignation or removal: Eric D. Belcher</voteDescription>
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      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
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        <sharesVoted>193691.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
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    <voteDescription>To elect nine directors to serve until the next annual meeting and their successors are duly elected and qualified, or until their earlier death, resignation or removal: Jennifer A. Doudna</voteDescription>
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      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
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        <sharesVoted>193691.000000</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
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    <voteDescription>To elect nine directors to serve until the next annual meeting and their successors are duly elected and qualified, or until their earlier death, resignation or removal: David R. Epstein</voteDescription>
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      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
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        <sharesVoted>193691.000000</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
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    <voteDescription>To elect nine directors to serve until the next annual meeting and their successors are duly elected and qualified, or until their earlier death, resignation or removal: Wayne A.I. Frederick, M.D.</voteDescription>
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      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
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        <sharesVoted>193691.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
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    <meetingDate>05/20/2025</meetingDate>
    <voteDescription>To elect nine directors to serve until the next annual meeting and their successors are duly elected and qualified, or until their earlier death, resignation or removal: Scott Gottlieb, M.D.</voteDescription>
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      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
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        <sharesVoted>193691.000000</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
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    <voteDescription>To elect nine directors to serve until the next annual meeting and their successors are duly elected and qualified, or until their earlier death, resignation or removal: Theodore J. Leonsis</voteDescription>
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      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
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    <sharesVoted>193691.000000</sharesVoted>
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    <vote>
      <voteRecord>
        <howVoted>WITHHOLD</howVoted>
        <sharesVoted>193691.000000</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
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    <issuerName>Tempus AI, Inc.</issuerName>
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    <meetingDate>05/20/2025</meetingDate>
    <voteDescription>To elect nine directors to serve until the next annual meeting and their successors are duly elected and qualified, or until their earlier death, resignation or removal: Nadja West, M.D.</voteDescription>
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      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
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    <vote>
      <voteRecord>
        <howVoted>WITHHOLD</howVoted>
        <sharesVoted>193691.000000</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
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    <meetingDate>05/20/2025</meetingDate>
    <voteDescription>To ratify the appointment by the Audit Committee of the Board of Directors of PricewaterhouseCoopers LLP as the Company's independent registered public accounting firm for the fiscal year ending December 31, 2025.</voteDescription>
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      <voteCategory>
        <categoryType>AUDIT-RELATED</categoryType>
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    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>193691.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Tempus AI, Inc.</issuerName>
    <cusip>88023B103</cusip>
    <isin>US88023B1035</isin>
    <meetingDate>05/20/2025</meetingDate>
    <voteDescription>To approve the reincorporation of the Company from the State of Delaware to the State of Nevada by conversion.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>EXTRAORDINARY TRANSACTIONS</categoryType>
      </voteCategory>
      <voteCategory>
        <categoryType>CORPORATE GOVERNANCE</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>193691.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>AGAINST</howVoted>
        <sharesVoted>193691.000000</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Alkermes plc</issuerName>
    <cusip>G01767105</cusip>
    <isin>IE00B56GVS15</isin>
    <meetingDate>05/21/2025</meetingDate>
    <voteDescription>To elect as directors to serve a one-year term until the Company's 2026 annual general meeting of shareholders: Shane M. Cooke</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>89235.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>89235.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Alkermes plc</issuerName>
    <cusip>G01767105</cusip>
    <isin>IE00B56GVS15</isin>
    <meetingDate>05/21/2025</meetingDate>
    <voteDescription>To elect as directors to serve a one-year term until the Company's 2026 annual general meeting of shareholders: Richard B. Gaynor, M.D.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>89235.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>89235.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Alkermes plc</issuerName>
    <cusip>G01767105</cusip>
    <isin>IE00B56GVS15</isin>
    <meetingDate>05/21/2025</meetingDate>
    <voteDescription>To elect as directors to serve a one-year term until the Company's 2026 annual general meeting of shareholders: Cato T. Laurencin, M.D., Ph.D.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>89235.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>89235.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Alkermes plc</issuerName>
    <cusip>G01767105</cusip>
    <isin>IE00B56GVS15</isin>
    <meetingDate>05/21/2025</meetingDate>
    <voteDescription>To elect as directors to serve a one-year term until the Company's 2026 annual general meeting of shareholders: Nancy S. Lurker</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>89235.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>89235.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Alkermes plc</issuerName>
    <cusip>G01767105</cusip>
    <isin>IE00B56GVS15</isin>
    <meetingDate>05/21/2025</meetingDate>
    <voteDescription>To elect as directors to serve a one-year term until the Company's 2026 annual general meeting of shareholders: Brian P. McKeon</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>89235.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>89235.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Alkermes plc</issuerName>
    <cusip>G01767105</cusip>
    <isin>IE00B56GVS15</isin>
    <meetingDate>05/21/2025</meetingDate>
    <voteDescription>To elect as directors to serve a one-year term until the Company's 2026 annual general meeting of shareholders: Richard F. Pops</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>89235.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>89235.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Alkermes plc</issuerName>
    <cusip>G01767105</cusip>
    <isin>IE00B56GVS15</isin>
    <meetingDate>05/21/2025</meetingDate>
    <voteDescription>To elect as directors to serve a one-year term until the Company's 2026 annual general meeting of shareholders: Nancy L. Snyderman, M.D.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>89235.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>89235.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Alkermes plc</issuerName>
    <cusip>G01767105</cusip>
    <isin>IE00B56GVS15</isin>
    <meetingDate>05/21/2025</meetingDate>
    <voteDescription>To elect as directors to serve a one-year term until the Company's 2026 annual general meeting of shareholders: Frank Anders Wilson</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>89235.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>89235.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Alkermes plc</issuerName>
    <cusip>G01767105</cusip>
    <isin>IE00B56GVS15</isin>
    <meetingDate>05/21/2025</meetingDate>
    <voteDescription>To elect as directors to serve a one-year term until the Company's 2026 annual general meeting of shareholders: Christopher I. Wright, M.D., Ph.D.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>89235.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>89235.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Alkermes plc</issuerName>
    <cusip>G01767105</cusip>
    <isin>IE00B56GVS15</isin>
    <meetingDate>05/21/2025</meetingDate>
    <voteDescription>To approve, in a non-binding, advisory vote, the compensation of the Company's named executive officers.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>89235.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>89235.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Alkermes plc</issuerName>
    <cusip>G01767105</cusip>
    <isin>IE00B56GVS15</isin>
    <meetingDate>05/21/2025</meetingDate>
    <voteDescription>To ratify, in a non-binding vote, the appointment of PricewaterhouseCoopers LLP as the independent auditor and accounting firm of the Company and to authorize, in a binding vote, the Audit and Risk Committee of the Board to set the independent auditor and accounting firm's remuneration.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>AUDIT-RELATED</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>89235.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>89235.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Alkermes plc</issuerName>
    <cusip>G01767105</cusip>
    <isin>IE00B56GVS15</isin>
    <meetingDate>05/21/2025</meetingDate>
    <voteDescription>To approve the Alkermes plc 2018 Stock Option and Incentive Plan, as amended.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>COMPENSATION</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>89235.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>89235.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Alkermes plc</issuerName>
    <cusip>G01767105</cusip>
    <isin>IE00B56GVS15</isin>
    <meetingDate>05/21/2025</meetingDate>
    <voteDescription>To renew Board authority to allot and issue shares under Irish law.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>CAPITAL STRUCTURE</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>89235.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>89235.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Alkermes plc</issuerName>
    <cusip>G01767105</cusip>
    <isin>IE00B56GVS15</isin>
    <meetingDate>05/21/2025</meetingDate>
    <voteDescription>To renew Board authority to disapply the statutory pre-emption rights that would otherwise apply under Irish law.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>CAPITAL STRUCTURE</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>89235.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>AGAINST</howVoted>
        <sharesVoted>89235.000000</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Geron Corporation</issuerName>
    <cusip>374163103</cusip>
    <isin>US3741631036</isin>
    <meetingDate>05/21/2025</meetingDate>
    <voteDescription>To elect the two nominees for director named below to hold office as Class II members of the Board of Directors until the 2028 annual meeting of stockholders: Dawn C. Bir</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>2332131.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>2332131.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Geron Corporation</issuerName>
    <cusip>374163103</cusip>
    <isin>US3741631036</isin>
    <meetingDate>05/21/2025</meetingDate>
    <voteDescription>To elect the two nominees for director named below to hold office as Class II members of the Board of Directors until the 2028 annual meeting of stockholders: Elizabeth G. O'Farrell</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>2332131.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>2332131.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Geron Corporation</issuerName>
    <cusip>374163103</cusip>
    <isin>US3741631036</isin>
    <meetingDate>05/21/2025</meetingDate>
    <voteDescription>To approve an amendment to our 2018 Equity Incentive Plan to, among other items, increase the total number of shares of our common stock issuable thereunder by 20,000,000 shares.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>COMPENSATION</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>2332131.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>2332131.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Geron Corporation</issuerName>
    <cusip>374163103</cusip>
    <isin>US3741631036</isin>
    <meetingDate>05/21/2025</meetingDate>
    <voteDescription>To approve an amendment to our 2014 Employee Stock Purchase Plan to increase the number of shares of our common stock issuable thereunder by 6,000,000 shares.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>COMPENSATION</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>2332131.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>2332131.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Geron Corporation</issuerName>
    <cusip>374163103</cusip>
    <isin>US3741631036</isin>
    <meetingDate>05/21/2025</meetingDate>
    <voteDescription>To approve, on an advisory basis, the compensation of our Named Executive Officers, as disclosed in our Proxy Statement.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>2332131.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>AGAINST</howVoted>
        <sharesVoted>2332131.000000</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Geron Corporation</issuerName>
    <cusip>374163103</cusip>
    <isin>US3741631036</isin>
    <meetingDate>05/21/2025</meetingDate>
    <voteDescription>To ratify the selection of Ernst &amp; Young LLP as our independent registered public accounting firm for the fiscal year ending December 31, 2025.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>AUDIT-RELATED</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>2332131.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>AGAINST</howVoted>
        <sharesVoted>2332131.000000</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Illumina, Inc.</issuerName>
    <cusip>452327109</cusip>
    <isin>US4523271090</isin>
    <meetingDate>05/21/2025</meetingDate>
    <voteDescription>Election of Directors: Frances Arnold, Ph.D.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>143240.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>143240.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Illumina, Inc.</issuerName>
    <cusip>452327109</cusip>
    <isin>US4523271090</isin>
    <meetingDate>05/21/2025</meetingDate>
    <voteDescription>Election of Directors: Caroline D. Dorsa</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>143240.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>143240.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Illumina, Inc.</issuerName>
    <cusip>452327109</cusip>
    <isin>US4523271090</isin>
    <meetingDate>05/21/2025</meetingDate>
    <voteDescription>Election of Directors: Robert S. Epstein, M.D.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>143240.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>143240.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Illumina, Inc.</issuerName>
    <cusip>452327109</cusip>
    <isin>US4523271090</isin>
    <meetingDate>05/21/2025</meetingDate>
    <voteDescription>Election of Directors: Scott Gottlieb, M.D.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>143240.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>143240.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Illumina, Inc.</issuerName>
    <cusip>452327109</cusip>
    <isin>US4523271090</isin>
    <meetingDate>05/21/2025</meetingDate>
    <voteDescription>Election of Directors: Gary S. Guthart, Ph.D.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>143240.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>143240.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Illumina, Inc.</issuerName>
    <cusip>452327109</cusip>
    <isin>US4523271090</isin>
    <meetingDate>05/21/2025</meetingDate>
    <voteDescription>Election of Directors: Keith A. Meister</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>143240.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>143240.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Illumina, Inc.</issuerName>
    <cusip>452327109</cusip>
    <isin>US4523271090</isin>
    <meetingDate>05/21/2025</meetingDate>
    <voteDescription>Election of Directors: Anna Richo</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>143240.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>143240.000000</sharesVoted>
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        <sharesVoted>35984.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Tenet Healthcare Corporation</issuerName>
    <cusip>88033G407</cusip>
    <isin>US88033G4073</isin>
    <meetingDate>05/22/2025</meetingDate>
    <voteDescription>To approve, on an advisory basis, the Company's executive compensation.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>35984.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>AGAINST</howVoted>
        <sharesVoted>35984.000000</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Tenet Healthcare Corporation</issuerName>
    <cusip>88033G407</cusip>
    <isin>US88033G4073</isin>
    <meetingDate>05/22/2025</meetingDate>
    <voteDescription>To ratify the selection of Deloitte &amp; Touche LLP as the Company's independent registered public accountants for the year ending December 31, 2025.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>AUDIT-RELATED</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>35984.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>35984.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Tenet Healthcare Corporation</issuerName>
    <cusip>88033G407</cusip>
    <isin>US88033G4073</isin>
    <meetingDate>05/22/2025</meetingDate>
    <voteDescription>To report on strategies and programs for improving maternal health outcomes.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>OTHER SOCIAL ISSUES</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>SECURITY HOLDER</voteSource>
    <sharesVoted>35984.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>AGAINST</howVoted>
        <sharesVoted>35984.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Amgen Inc.</issuerName>
    <cusip>031162100</cusip>
    <isin>US0311621009</isin>
    <meetingDate>05/23/2025</meetingDate>
    <voteDescription>To elect twelve directors to the Board of Directors of Amgen Inc. for a term of office expiring at the 2026 annual meeting of stockholders. The nominees for election to the Board of Directors are: Dr. Wanda M. Austin</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>201529.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>201529.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Amgen Inc.</issuerName>
    <cusip>031162100</cusip>
    <isin>US0311621009</isin>
    <meetingDate>05/23/2025</meetingDate>
    <voteDescription>To elect twelve directors to the Board of Directors of Amgen Inc. for a term of office expiring at the 2026 annual meeting of stockholders. The nominees for election to the Board of Directors are: Mr. Robert A. Bradway</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>201529.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>201529.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Amgen Inc.</issuerName>
    <cusip>031162100</cusip>
    <isin>US0311621009</isin>
    <meetingDate>05/23/2025</meetingDate>
    <voteDescription>To elect twelve directors to the Board of Directors of Amgen Inc. for a term of office expiring at the 2026 annual meeting of stockholders. The nominees for election to the Board of Directors are: Dr. Michael V. Drake</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>201529.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>201529.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Amgen Inc.</issuerName>
    <cusip>031162100</cusip>
    <isin>US0311621009</isin>
    <meetingDate>05/23/2025</meetingDate>
    <voteDescription>To elect twelve directors to the Board of Directors of Amgen Inc. for a term of office expiring at the 2026 annual meeting of stockholders. The nominees for election to the Board of Directors are: Dr. Brian J. Druker</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>201529.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>201529.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Amgen Inc.</issuerName>
    <cusip>031162100</cusip>
    <isin>US0311621009</isin>
    <meetingDate>05/23/2025</meetingDate>
    <voteDescription>To elect twelve directors to the Board of Directors of Amgen Inc. for a term of office expiring at the 2026 annual meeting of stockholders. The nominees for election to the Board of Directors are: Mr. Robert A. Eckert</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>201529.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>201529.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Amgen Inc.</issuerName>
    <cusip>031162100</cusip>
    <isin>US0311621009</isin>
    <meetingDate>05/23/2025</meetingDate>
    <voteDescription>To elect twelve directors to the Board of Directors of Amgen Inc. for a term of office expiring at the 2026 annual meeting of stockholders. The nominees for election to the Board of Directors are: Mr. Greg C. Garland</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>201529.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>201529.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Amgen Inc.</issuerName>
    <cusip>031162100</cusip>
    <isin>US0311621009</isin>
    <meetingDate>05/23/2025</meetingDate>
    <voteDescription>To elect twelve directors to the Board of Directors of Amgen Inc. for a term of office expiring at the 2026 annual meeting of stockholders. The nominees for election to the Board of Directors are: Mr. Charles M. Holley, Jr.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>201529.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>201529.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Amgen Inc.</issuerName>
    <cusip>031162100</cusip>
    <isin>US0311621009</isin>
    <meetingDate>05/23/2025</meetingDate>
    <voteDescription>To elect twelve directors to the Board of Directors of Amgen Inc. for a term of office expiring at the 2026 annual meeting of stockholders. The nominees for election to the Board of Directors are: Dr. S. Omar Ishrak</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>201529.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>201529.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Amgen Inc.</issuerName>
    <cusip>031162100</cusip>
    <isin>US0311621009</isin>
    <meetingDate>05/23/2025</meetingDate>
    <voteDescription>To elect twelve directors to the Board of Directors of Amgen Inc. for a term of office expiring at the 2026 annual meeting of stockholders. The nominees for election to the Board of Directors are: Dr. Tyler Jacks</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>201529.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>201529.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Amgen Inc.</issuerName>
    <cusip>031162100</cusip>
    <isin>US0311621009</isin>
    <meetingDate>05/23/2025</meetingDate>
    <voteDescription>To elect twelve directors to the Board of Directors of Amgen Inc. for a term of office expiring at the 2026 annual meeting of stockholders. The nominees for election to the Board of Directors are: Dr. Mary E. Klotman</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>201529.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>201529.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Amgen Inc.</issuerName>
    <cusip>031162100</cusip>
    <isin>US0311621009</isin>
    <meetingDate>05/23/2025</meetingDate>
    <voteDescription>To elect twelve directors to the Board of Directors of Amgen Inc. for a term of office expiring at the 2026 annual meeting of stockholders. The nominees for election to the Board of Directors are: Ms. Ellen J. Kullman</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>201529.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>201529.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Amgen Inc.</issuerName>
    <cusip>031162100</cusip>
    <isin>US0311621009</isin>
    <meetingDate>05/23/2025</meetingDate>
    <voteDescription>To elect twelve directors to the Board of Directors of Amgen Inc. for a term of office expiring at the 2026 annual meeting of stockholders. The nominees for election to the Board of Directors are: Ms. Amy E. Miles</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>201529.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>201529.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Amgen Inc.</issuerName>
    <cusip>031162100</cusip>
    <isin>US0311621009</isin>
    <meetingDate>05/23/2025</meetingDate>
    <voteDescription>Advisory vote to approve our executive compensation.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>201529.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>AGAINST</howVoted>
        <sharesVoted>201529.000000</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Amgen Inc.</issuerName>
    <cusip>031162100</cusip>
    <isin>US0311621009</isin>
    <meetingDate>05/23/2025</meetingDate>
    <voteDescription>To ratify the selection of Ernst &amp; Young LLP as our independent registered public accountants for the fiscal year ending December 31, 2025.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>AUDIT-RELATED</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>201529.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>AGAINST</howVoted>
        <sharesVoted>201529.000000</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>argenx SE</issuerName>
    <cusip>04016X101</cusip>
    <isin>US04016X1019</isin>
    <meetingDate>05/27/2025</meetingDate>
    <voteDescription>Approve Remuneration Report</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>COMPENSATION</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>29509.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>AGAINST</howVoted>
        <sharesVoted>29509.000000</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>argenx SE</issuerName>
    <cusip>04016X101</cusip>
    <isin>US04016X1019</isin>
    <meetingDate>05/27/2025</meetingDate>
    <voteDescription>Adopt Financial Statements and Statutory Reports</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>CORPORATE GOVERNANCE</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>29509.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>29509.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>argenx SE</issuerName>
    <cusip>04016X101</cusip>
    <isin>US04016X1019</isin>
    <meetingDate>05/27/2025</meetingDate>
    <voteDescription>Approve Allocation of Income to the Retained Earnings of the Company</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>CAPITAL STRUCTURE</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>29509.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>29509.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>argenx SE</issuerName>
    <cusip>04016X101</cusip>
    <isin>US04016X1019</isin>
    <meetingDate>05/27/2025</meetingDate>
    <voteDescription>Approve Discharge of Directors</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>CORPORATE GOVERNANCE</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>29509.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>29509.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>argenx SE</issuerName>
    <cusip>04016X101</cusip>
    <isin>US04016X1019</isin>
    <meetingDate>05/27/2025</meetingDate>
    <voteDescription>Approve Remuneration Policy</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>COMPENSATION</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>29509.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>AGAINST</howVoted>
        <sharesVoted>29509.000000</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>argenx SE</issuerName>
    <cusip>04016X101</cusip>
    <isin>US04016X1019</isin>
    <meetingDate>05/27/2025</meetingDate>
    <voteDescription>Reelect Anthony Rosenberg as Non-Executive Director</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>29509.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>29509.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>argenx SE</issuerName>
    <cusip>04016X101</cusip>
    <isin>US04016X1019</isin>
    <meetingDate>05/27/2025</meetingDate>
    <voteDescription>Grant Board Authority to Issue Shares and Exclude Pre-emptive Rights</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>CAPITAL STRUCTURE</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>29509.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>29509.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Ascendis Pharma A/S</issuerName>
    <cusip>04351P101</cusip>
    <isin>US04351P1012</isin>
    <meetingDate>05/27/2025</meetingDate>
    <voteDescription>Elect Lars Luthjohan as Chair of Meeting</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>CORPORATE GOVERNANCE</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>96830.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>96830.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Ascendis Pharma A/S</issuerName>
    <cusip>04351P101</cusip>
    <isin>US04351P1012</isin>
    <meetingDate>05/27/2025</meetingDate>
    <voteDescription>Accept Financial Statements and Statutory Reports; Approve Discharge of Management and Board</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>CAPITAL STRUCTURE</categoryType>
      </voteCategory>
      <voteCategory>
        <categoryType>CORPORATE GOVERNANCE</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>96830.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>96830.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Ascendis Pharma A/S</issuerName>
    <cusip>04351P101</cusip>
    <isin>US04351P1012</isin>
    <meetingDate>05/27/2025</meetingDate>
    <voteDescription>Approve Treatment of Net Loss</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>CAPITAL STRUCTURE</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>96830.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>96830.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Ascendis Pharma A/S</issuerName>
    <cusip>04351P101</cusip>
    <isin>US04351P1012</isin>
    <meetingDate>05/27/2025</meetingDate>
    <voteDescription>Reelect Albert Cha as Director</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>96830.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
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    <voteDescription>To ratify the appointment by the Audit Committee of the Board of Directors of Ernst &amp; Young LLP as the Company's independent registered public accounting firm for the fiscal year ending December 31, 2025.</voteDescription>
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    <voteDescription>Election of Directors: Charles Baker</voteDescription>
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    <voteDescription>Election of Directors: F. William McNabb III</voteDescription>
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    <voteDescription>Ratification of the appointment of Deloitte &amp; Touche LLP as the independent registered public accounting firm for the Company for the year ending December 31, 2025.</voteDescription>
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    <voteDescription>To elect two class III directors, Judy Chou, Ph.D. and Tomas Heyman, to our board of directors, to serve until the 2028 Annual Meeting of stockholders and until her or his successor has been duly elected and qualified, or until her or his earlier death, resignation or removal: Judy Chou, Ph.D.</voteDescription>
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    <voteDescription>To elect two class III directors, Judy Chou, Ph.D. and Tomas Heyman, to our board of directors, to serve until the 2028 Annual Meeting of stockholders and until her or his successor has been duly elected and qualified, or until her or his earlier death, resignation or removal: Tomas Heyman</voteDescription>
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    <voteDescription>To ratify the appointment of Deloitte &amp; Touche LLP as our independent registered public accounting firm for the fiscal year ending December 31, 2025.</voteDescription>
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    <voteDescription>Approve Equity-Based Remuneration of Directors in the Amount of USD 2.2 Million</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>COMPENSATION</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>0.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
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    <cusip>H5870P102</cusip>
    <isin>CH1242303498</isin>
    <meetingDate>06/04/2025</meetingDate>
    <voteDescription>Approve Fixed Remuneration of Executive Committee in the Amount of USD 2.5 Million</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>COMPENSATION</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>0.000000</sharesVoted>
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    <cusip>H5870P102</cusip>
    <isin>CH1242303498</isin>
    <meetingDate>06/04/2025</meetingDate>
    <voteDescription>Approve Variable Remuneration of Executive Committee in the Amount of USD 1.8 Million</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>COMPENSATION</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>0.000000</sharesVoted>
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    <issuerName>Oculis Holding AG</issuerName>
    <cusip>H5870P102</cusip>
    <isin>CH1242303498</isin>
    <meetingDate>06/04/2025</meetingDate>
    <voteDescription>Approve Equity-Based Remuneration of Executive Committee in the Amount of USD 15.5 Million</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>COMPENSATION</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>0.000000</sharesVoted>
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  <proxyTable>
    <issuerName>Oculis Holding AG</issuerName>
    <cusip>H5870P102</cusip>
    <isin>CH1242303498</isin>
    <meetingDate>06/04/2025</meetingDate>
    <voteDescription>Approve Remuneration Report (Non-Binding)</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>COMPENSATION</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>0.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
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    <cusip>H5870P102</cusip>
    <isin>CH1242303498</isin>
    <meetingDate>06/04/2025</meetingDate>
    <voteDescription>Approve Creation of Capital Band within the Upper Limit of CHF 818,005 and the Lower Limit of CHF 545,337 with or without Exclusion of Preemptive Rights</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>CAPITAL STRUCTURE</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>0.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
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    <issuerName>Oculis Holding AG</issuerName>
    <cusip>H5870P102</cusip>
    <isin>CH1242303498</isin>
    <meetingDate>06/04/2025</meetingDate>
    <voteDescription>Approve Creation of CHF 124,800 Pool of Conditional Capital for Employee Equity Plans</voteDescription>
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      <voteCategory>
        <categoryType>COMPENSATION</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>0.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
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    <issuerName>Oculis Holding AG</issuerName>
    <cusip>H5870P102</cusip>
    <isin>CH1242303498</isin>
    <meetingDate>06/04/2025</meetingDate>
    <voteDescription>Transact Other Business (Voting)</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>CORPORATE GOVERNANCE</categoryType>
      </voteCategory>
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    <voteSource>ISSUER</voteSource>
    <sharesVoted>0.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
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    <issuerName>Xenon Pharmaceuticals Inc.</issuerName>
    <cusip>98420N105</cusip>
    <isin>CA98420N1050</isin>
    <meetingDate>06/04/2025</meetingDate>
    <voteDescription>To elect as directors of the Corporation the eight nominees named in the accompanying Proxy Statement and Management Information Circular to hold office until the next annual meeting of the Corporation or until their successors are duly elected: Dawn Svoronos</voteDescription>
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      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>269103.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
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      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>269103.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
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    <issuerName>Xenon Pharmaceuticals Inc.</issuerName>
    <cusip>98420N105</cusip>
    <isin>CA98420N1050</isin>
    <meetingDate>06/04/2025</meetingDate>
    <voteDescription>To elect as directors of the Corporation the eight nominees named in the accompanying Proxy Statement and Management Information Circular to hold office until the next annual meeting of the Corporation or until their successors are duly elected: Gillian Cannon</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>269103.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>269103.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
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    <issuerName>Xenon Pharmaceuticals Inc.</issuerName>
    <cusip>98420N105</cusip>
    <isin>CA98420N1050</isin>
    <meetingDate>06/04/2025</meetingDate>
    <voteDescription>To elect as directors of the Corporation the eight nominees named in the accompanying Proxy Statement and Management Information Circular to hold office until the next annual meeting of the Corporation or until their successors are duly elected: Steven Gannon</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>269103.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>269103.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
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    <issuerName>Xenon Pharmaceuticals Inc.</issuerName>
    <cusip>98420N105</cusip>
    <isin>CA98420N1050</isin>
    <meetingDate>06/04/2025</meetingDate>
    <voteDescription>To elect as directors of the Corporation the eight nominees named in the accompanying Proxy Statement and Management Information Circular to hold office until the next annual meeting of the Corporation or until their successors are duly elected: Elizabeth Garofalo</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>269103.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>269103.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
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    <issuerName>Xenon Pharmaceuticals Inc.</issuerName>
    <cusip>98420N105</cusip>
    <isin>CA98420N1050</isin>
    <meetingDate>06/04/2025</meetingDate>
    <voteDescription>To elect as directors of the Corporation the eight nominees named in the accompanying Proxy Statement and Management Information Circular to hold office until the next annual meeting of the Corporation or until their successors are duly elected: Justin Gover</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>269103.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>269103.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
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    <issuerName>Xenon Pharmaceuticals Inc.</issuerName>
    <cusip>98420N105</cusip>
    <isin>CA98420N1050</isin>
    <meetingDate>06/04/2025</meetingDate>
    <voteDescription>To elect as directors of the Corporation the eight nominees named in the accompanying Proxy Statement and Management Information Circular to hold office until the next annual meeting of the Corporation or until their successors are duly elected: Patrick Machado</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
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    <voteSource>ISSUER</voteSource>
    <sharesVoted>269103.000000</sharesVoted>
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    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>269103.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
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    <issuerName>Xenon Pharmaceuticals Inc.</issuerName>
    <cusip>98420N105</cusip>
    <isin>CA98420N1050</isin>
    <meetingDate>06/04/2025</meetingDate>
    <voteDescription>To elect as directors of the Corporation the eight nominees named in the accompanying Proxy Statement and Management Information Circular to hold office until the next annual meeting of the Corporation or until their successors are duly elected: Ian Mortimer</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
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    <voteSource>ISSUER</voteSource>
    <sharesVoted>269103.000000</sharesVoted>
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    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>269103.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
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    <issuerName>Xenon Pharmaceuticals Inc.</issuerName>
    <cusip>98420N105</cusip>
    <isin>CA98420N1050</isin>
    <meetingDate>06/04/2025</meetingDate>
    <voteDescription>To elect as directors of the Corporation the eight nominees named in the accompanying Proxy Statement and Management Information Circular to hold office until the next annual meeting of the Corporation or until their successors are duly elected: Gary Patou</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
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    <voteSource>ISSUER</voteSource>
    <sharesVoted>269103.000000</sharesVoted>
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        <howVoted>FOR</howVoted>
        <sharesVoted>269103.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
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    <issuerName>Xenon Pharmaceuticals Inc.</issuerName>
    <cusip>98420N105</cusip>
    <isin>CA98420N1050</isin>
    <meetingDate>06/04/2025</meetingDate>
    <voteDescription>To approve, on an advisory basis, the compensation of the Corporation's named executive officers;</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
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    <voteSource>ISSUER</voteSource>
    <sharesVoted>269103.000000</sharesVoted>
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    <vote>
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        <howVoted>FOR</howVoted>
        <sharesVoted>269103.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
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    <issuerName>Xenon Pharmaceuticals Inc.</issuerName>
    <cusip>98420N105</cusip>
    <isin>CA98420N1050</isin>
    <meetingDate>06/04/2025</meetingDate>
    <voteDescription>To appoint PricewaterhouseCoopers LLP (&quot;PwC&quot;) as the Corporation's auditor to hold office until the next annual meeting of the Corporation;</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>AUDIT-RELATED</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>269103.000000</sharesVoted>
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    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>269103.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
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    <issuerName>Xenon Pharmaceuticals Inc.</issuerName>
    <cusip>98420N105</cusip>
    <isin>CA98420N1050</isin>
    <meetingDate>06/04/2025</meetingDate>
    <voteDescription>To authorize the Audit Committee of the board of directors of the Corporation to fix the remuneration to be paid to the auditors of the Corporation;</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>AUDIT-RELATED</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>269103.000000</sharesVoted>
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    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>269103.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
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    <issuerName>Amylyx Pharmaceuticals, Inc.</issuerName>
    <cusip>03237H101</cusip>
    <isin>US03237H1014</isin>
    <meetingDate>06/05/2025</meetingDate>
    <voteDescription>Election of Directors: To elect the following persons to our board of directors, each to serve as a Class I director until the 2028 Annual Meeting of Stockholders and until their successor has been duly elected and qualified, or until such director's earlier death, resignation or removal: Karen Firestone</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>1731822.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>WITHHOLD</howVoted>
        <sharesVoted>1731822.000000</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
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    <issuerName>Amylyx Pharmaceuticals, Inc.</issuerName>
    <cusip>03237H101</cusip>
    <isin>US03237H1014</isin>
    <meetingDate>06/05/2025</meetingDate>
    <voteDescription>Election of Directors: To elect the following persons to our board of directors, each to serve as a Class I director until the 2028 Annual Meeting of Stockholders and until their successor has been duly elected and qualified, or until such director's earlier death, resignation or removal: Justin Klee</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>1731822.000000</sharesVoted>
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    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>1731822.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
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  <proxyTable>
    <issuerName>Amylyx Pharmaceuticals, Inc.</issuerName>
    <cusip>03237H101</cusip>
    <isin>US03237H1014</isin>
    <meetingDate>06/05/2025</meetingDate>
    <voteDescription>Election of Directors: To elect the following persons to our board of directors, each to serve as a Class I director until the 2028 Annual Meeting of Stockholders and until their successor has been duly elected and qualified, or until such director's earlier death, resignation or removal: Bernhardt Zeiher, M.D.</voteDescription>
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      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
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    <voteSource>ISSUER</voteSource>
    <sharesVoted>1731822.000000</sharesVoted>
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    <vote>
      <voteRecord>
        <howVoted>WITHHOLD</howVoted>
        <sharesVoted>1731822.000000</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
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  <proxyTable>
    <issuerName>Amylyx Pharmaceuticals, Inc.</issuerName>
    <cusip>03237H101</cusip>
    <isin>US03237H1014</isin>
    <meetingDate>06/05/2025</meetingDate>
    <voteDescription>To ratify the appointment of Deloitte &amp; Touche LLP as our independent registered public accounting firm for the fiscal year ending December 31, 2025.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>AUDIT-RELATED</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>1731822.000000</sharesVoted>
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    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>1731822.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
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    <issuerName>Amylyx Pharmaceuticals, Inc.</issuerName>
    <cusip>03237H101</cusip>
    <isin>US03237H1014</isin>
    <meetingDate>06/05/2025</meetingDate>
    <voteDescription>To approve, on a non-binding, advisory basis, the compensation of our named executives officers.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>1731822.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>AGAINST</howVoted>
        <sharesVoted>1731822.000000</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
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    <issuerName>Ionis Pharmaceuticals, Inc.</issuerName>
    <cusip>462222100</cusip>
    <isin>US4622221004</isin>
    <meetingDate>06/05/2025</meetingDate>
    <voteDescription>Election of Directors: Allene M. Diaz</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>264178.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>264178.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
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  <proxyTable>
    <issuerName>Ionis Pharmaceuticals, Inc.</issuerName>
    <cusip>462222100</cusip>
    <isin>US4622221004</isin>
    <meetingDate>06/05/2025</meetingDate>
    <voteDescription>Election of Directors: Michael Hayden</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>264178.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>264178.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
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  <proxyTable>
    <issuerName>Ionis Pharmaceuticals, Inc.</issuerName>
    <cusip>462222100</cusip>
    <isin>US4622221004</isin>
    <meetingDate>06/05/2025</meetingDate>
    <voteDescription>Election of Directors: Joseph Klein, III</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>264178.000000</sharesVoted>
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    <vote>
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        <howVoted>AGAINST</howVoted>
        <sharesVoted>264178.000000</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
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  <proxyTable>
    <issuerName>Ionis Pharmaceuticals, Inc.</issuerName>
    <cusip>462222100</cusip>
    <isin>US4622221004</isin>
    <meetingDate>06/05/2025</meetingDate>
    <voteDescription>Election of Directors: Joseph Loscalzo</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>264178.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>264178.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
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  <proxyTable>
    <issuerName>Ionis Pharmaceuticals, Inc.</issuerName>
    <cusip>462222100</cusip>
    <isin>US4622221004</isin>
    <meetingDate>06/05/2025</meetingDate>
    <voteDescription>To make an advisory vote on executive compensation.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>264178.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>264178.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
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  <proxyTable>
    <issuerName>Ionis Pharmaceuticals, Inc.</issuerName>
    <cusip>462222100</cusip>
    <isin>US4622221004</isin>
    <meetingDate>06/05/2025</meetingDate>
    <voteDescription>To approve an amendment of the Ionis Pharmaceuticals, Inc. 2011 Equity Incentive Plan to increase the aggregate number of shares of common stock authorized for issuance under such plan by 4,000,000 shares to an aggregate of 42,500,000 shares.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>COMPENSATION</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>264178.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
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    <voteDescription>TO ELECT, AS CLASS II DIRECTORS TO HOLD OFFICE UNTIL THE 2027 ANNUAL MEETING OF STOCKHOLDERS, OR UNTIL THEIR SUCCESSORS ARE EARLIER ELECTED, THE FOLLOWING DIRECTOR NOMINEES: M. KATHLEEN BEHRENS, PH.D.</voteDescription>
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    <voteDescription>TO ELECT, AS CLASS II DIRECTORS TO HOLD OFFICE UNTIL THE 2027 ANNUAL MEETING OF STOCKHOLDERS, OR UNTIL THEIR SUCCESSORS ARE EARLIER ELECTED, THE FOLLOWING DIRECTOR NOMINEES: STEPHEN L. MAYO, PH.D.</voteDescription>
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    <voteDescription>TO ELECT, AS CLASS II DIRECTORS TO HOLD OFFICE UNTIL THE 2027 ANNUAL MEETING OF STOCKHOLDERS, OR UNTIL THEIR SUCCESSORS ARE EARLIER ELECTED, THE FOLLOWING DIRECTOR NOMINEES: CLAUDE NICAISE, M.D.</voteDescription>
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    <voteDescription>APPROVE AN AMENDMENT TO THE COMPANY'S 2018 EQUITY INCENTIVE PLAN (THE &quot;2018 PLAN&quot;) TO INCREASE THE MAXIMUM AGGREGATE NUMBER OF SHARES OF COMMON STOCK THAT MAY BE ISSUED PURSUANT TO AWARDS GRANTED UNDER THE 2018 PLAN BY 4,300,000 SHARES TO 17,487,596 SHARES</voteDescription>
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    <voteDescription>RATIFY THE SELECTION OF KPMG LLP AS THE COMPANY'S INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM FOR THE CURRENT YEAR ENDING DECEMBER 31, 2025</voteDescription>
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    <voteDescription>Election of Directors: Jane F. Barlow, M.D.</voteDescription>
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    <voteDescription>Election of Directors: Mansoor Raza Mirza, M.D.</voteDescription>
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    <voteDescription>Ratification of the appointment of Ernst &amp; Young LLP as our independent registered public accounting firm for our fiscal year ending December 31, 2025.</voteDescription>
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    <voteDescription>ELECTION OF DIRECTORS: Chen Lichtenstein - to serve until Teva's 2027 Annual Meeting</voteDescription>
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    <voteDescription>ELECTION OF DIRECTORS: Amir Elstein - to serve until Teva's 2028 Annual Meeting</voteDescription>
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    <voteDescription>ELECTION OF DIRECTORS: Dr. Perry D. Nisen to serve until Teva's 2028 Annual Meeting</voteDescription>
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    <voteDescription>ELECTION OF DIRECTORS: Dr. Tal Zaks to serve until Teva's 2028 Annual Meeting</voteDescription>
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    <voteDescription>TO APPOINT KESSELMAN &amp; KESSELMAN, A MEMBER OF PRICEWATERHOUSECOOPERS INTERNATIONAL LTD., AS TEVA'S INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM UNTIL TEVA'S 2026 ANNUAL MEETING OF SHAREHOLDERS</voteDescription>
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    <voteDescription>Election of Director: Roger Jeffs, Ph.D.</voteDescription>
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    <voteDescription>To ratify the appointment of Deloitte &amp; Touche LLP as the Company's independent registered public accounting firm for the year ending December 31, 2025.</voteDescription>
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    <voteDescription>To approve, by non-binding advisory vote, the compensation of our named executive officers.</voteDescription>
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      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>46864.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>46864.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Sutro Biopharma, Inc.</issuerName>
    <cusip>869367102</cusip>
    <isin>US8693671021</isin>
    <meetingDate>06/06/2025</meetingDate>
    <voteDescription>Election of Class I Directors: Heidi Hunter</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>69389.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>WITHHOLD</howVoted>
        <sharesVoted>69389.000000</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Sutro Biopharma, Inc.</issuerName>
    <cusip>869367102</cusip>
    <isin>US8693671021</isin>
    <meetingDate>06/06/2025</meetingDate>
    <voteDescription>Election of Class I Directors: Jon Wigginton, M.D.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>69389.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>WITHHOLD</howVoted>
        <sharesVoted>69389.000000</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Sutro Biopharma, Inc.</issuerName>
    <cusip>869367102</cusip>
    <isin>US8693671021</isin>
    <meetingDate>06/06/2025</meetingDate>
    <voteDescription>Election of Class I Directors: Michael Dybbs, Ph.D.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>69389.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>WITHHOLD</howVoted>
        <sharesVoted>69389.000000</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Sutro Biopharma, Inc.</issuerName>
    <cusip>869367102</cusip>
    <isin>US8693671021</isin>
    <meetingDate>06/06/2025</meetingDate>
    <voteDescription>To ratify the appointment of Ernst &amp; Young LLP as our independent registered public accounting firm for the fiscal year ending December 31, 2025.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>AUDIT-RELATED</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>69389.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>69389.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Sutro Biopharma, Inc.</issuerName>
    <cusip>869367102</cusip>
    <isin>US8693671021</isin>
    <meetingDate>06/06/2025</meetingDate>
    <voteDescription>To approve, on a non-binding, advisory basis, the compensation of our named executive officers.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>69389.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>69389.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Sutro Biopharma, Inc.</issuerName>
    <cusip>869367102</cusip>
    <isin>US8693671021</isin>
    <meetingDate>06/06/2025</meetingDate>
    <voteDescription>To approve an amendment to our Restated Certificate of Incorporation to effect a reverse stock split of our outstanding shares of common stock at a ratio of any whole number between 1-for-5 and 1-for-25, with the exact ratio determined by the board of directors in its discretion, subject to the board of directors authority to abandon such amendment.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>CAPITAL STRUCTURE</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>69389.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>69389.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Adaptive Biotechnologies Corporation</issuerName>
    <cusip>00650F109</cusip>
    <isin>US00650F1093</isin>
    <meetingDate>06/10/2025</meetingDate>
    <voteDescription>To elect one Class III director nominee to serve on the board of directors of Adaptive Biotechnologies Corporation for a three-year term expiring at the 2028 annual meeting of shareholders: Chad Robins</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>885180.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>WITHHOLD</howVoted>
        <sharesVoted>885180.000000</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Adaptive Biotechnologies Corporation</issuerName>
    <cusip>00650F109</cusip>
    <isin>US00650F1093</isin>
    <meetingDate>06/10/2025</meetingDate>
    <voteDescription>To approve, on a non-binding advisory basis, the compensation of our named executive officers as described in the proxy statement;</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>885180.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>885180.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Adaptive Biotechnologies Corporation</issuerName>
    <cusip>00650F109</cusip>
    <isin>US00650F1093</isin>
    <meetingDate>06/10/2025</meetingDate>
    <voteDescription>To ratify the appointment of Ernst &amp; Young LLP as our independent registered public accounting firm for the year ending December 31, 2025; and</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>AUDIT-RELATED</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>885180.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>885180.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Avidity Biosciences, Inc.</issuerName>
    <cusip>05370A108</cusip>
    <isin>US05370A1088</isin>
    <meetingDate>06/10/2025</meetingDate>
    <voteDescription>To elect Class II directors for a three-year term that expires at the 2028 Annual Meeting of Stockholders and until their respective successors shall have been duly elected and qualified: Arthur Levin, Ph.D.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>141554.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>141554.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Avidity Biosciences, Inc.</issuerName>
    <cusip>05370A108</cusip>
    <isin>US05370A1088</isin>
    <meetingDate>06/10/2025</meetingDate>
    <voteDescription>To elect Class II directors for a three-year term that expires at the 2028 Annual Meeting of Stockholders and until their respective successors shall have been duly elected and qualified: Simona Skerjanec</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>141554.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>141554.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Avidity Biosciences, Inc.</issuerName>
    <cusip>05370A108</cusip>
    <isin>US05370A1088</isin>
    <meetingDate>06/10/2025</meetingDate>
    <voteDescription>To elect Class II directors for a three-year term that expires at the 2028 Annual Meeting of Stockholders and until their respective successors shall have been duly elected and qualified: Tamar Thompson</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>141554.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>WITHHOLD</howVoted>
        <sharesVoted>141554.000000</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Avidity Biosciences, Inc.</issuerName>
    <cusip>05370A108</cusip>
    <isin>US05370A1088</isin>
    <meetingDate>06/10/2025</meetingDate>
    <voteDescription>To ratify the appointment of Deloitte &amp; Touche LLP as our independent public accounting firm for the fiscal year ending December 31, 2025;</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>AUDIT-RELATED</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>141554.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>141554.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Avidity Biosciences, Inc.</issuerName>
    <cusip>05370A108</cusip>
    <isin>US05370A1088</isin>
    <meetingDate>06/10/2025</meetingDate>
    <voteDescription>To consider and vote upon, on an advisory basis, the compensation of our named executive officers as disclosed in this proxy statement pursuant to the compensation disclosure rules of the Securities and Exchange Commission; and</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>141554.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>AGAINST</howVoted>
        <sharesVoted>141554.000000</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>LENZ Therapeutics, Inc.</issuerName>
    <cusip>52635N103</cusip>
    <isin>US52635N1037</isin>
    <meetingDate>06/10/2025</meetingDate>
    <voteDescription>To elect two Class III directors to hold office until our 2027 annual meeting of stockholders and two Class I directors to hold office until our 2028 annual meeting of stockholders, each until their respective successors are elected and qualified: Class III: Kimberlee C. Drapkin</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>36518.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>WITHHOLD</howVoted>
        <sharesVoted>36518.000000</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>LENZ Therapeutics, Inc.</issuerName>
    <cusip>52635N103</cusip>
    <isin>US52635N1037</isin>
    <meetingDate>06/10/2025</meetingDate>
    <voteDescription>To elect two Class III directors to hold office until our 2027 annual meeting of stockholders and two Class I directors to hold office until our 2028 annual meeting of stockholders, each until their respective successors are elected and qualified: Class III: Zach Scheiner</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>36518.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>WITHHOLD</howVoted>
        <sharesVoted>36518.000000</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>LENZ Therapeutics, Inc.</issuerName>
    <cusip>52635N103</cusip>
    <isin>US52635N1037</isin>
    <meetingDate>06/10/2025</meetingDate>
    <voteDescription>To elect two Class III directors to hold office until our 2027 annual meeting of stockholders and two Class I directors to hold office until our 2028 annual meeting of stockholders, each until their respective successors are elected and qualified: Class I: Frederic Guerard</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>36518.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>36518.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>LENZ Therapeutics, Inc.</issuerName>
    <cusip>52635N103</cusip>
    <isin>US52635N1037</isin>
    <meetingDate>06/10/2025</meetingDate>
    <voteDescription>To elect two Class III directors to hold office until our 2027 annual meeting of stockholders and two Class I directors to hold office until our 2028 annual meeting of stockholders, each until their respective successors are elected and qualified: Class I: James McCollum</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>36518.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>36518.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>LENZ Therapeutics, Inc.</issuerName>
    <cusip>52635N103</cusip>
    <isin>US52635N1037</isin>
    <meetingDate>06/10/2025</meetingDate>
    <voteDescription>To ratify the appointment of Ernst &amp; Young LLP as our independent registered public accounting firm for our fiscal year ending December 31, 2025.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>AUDIT-RELATED</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>36518.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>36518.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Crinetics Pharmaceuticals, Inc.</issuerName>
    <cusip>22663K107</cusip>
    <isin>US22663K1079</isin>
    <meetingDate>06/11/2025</meetingDate>
    <voteDescription>To elect three directors to serve as Class I directors for a three-year term to expire at the 2028 annual meeting of stockholders: Matthew K. Fust</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>167939.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>WITHHOLD</howVoted>
        <sharesVoted>167939.000000</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Crinetics Pharmaceuticals, Inc.</issuerName>
    <cusip>22663K107</cusip>
    <isin>US22663K1079</isin>
    <meetingDate>06/11/2025</meetingDate>
    <voteDescription>To elect three directors to serve as Class I directors for a three-year term to expire at the 2028 annual meeting of stockholders: R. Scott Struthers, Ph.D.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>167939.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>WITHHOLD</howVoted>
        <sharesVoted>167939.000000</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Crinetics Pharmaceuticals, Inc.</issuerName>
    <cusip>22663K107</cusip>
    <isin>US22663K1079</isin>
    <meetingDate>06/11/2025</meetingDate>
    <voteDescription>To elect three directors to serve as Class I directors for a three-year term to expire at the 2028 annual meeting of stockholders: Rogerio Vivaldi Coelho, M.D.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>167939.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>WITHHOLD</howVoted>
        <sharesVoted>167939.000000</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Crinetics Pharmaceuticals, Inc.</issuerName>
    <cusip>22663K107</cusip>
    <isin>US22663K1079</isin>
    <meetingDate>06/11/2025</meetingDate>
    <voteDescription>To consider and vote upon the ratification of the selection of BDO USA, P.C. as our independent registered public accounting firm for the fiscal year ending December 31, 2025;</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>AUDIT-RELATED</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>167939.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>167939.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Crinetics Pharmaceuticals, Inc.</issuerName>
    <cusip>22663K107</cusip>
    <isin>US22663K1079</isin>
    <meetingDate>06/11/2025</meetingDate>
    <voteDescription>To consider and vote upon, on an advisory basis, the compensation of the Company's named executive officers as disclosed in the proxy statement pursuant to the compensation disclosure rules of the Securities and Exchange Commission;</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>167939.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>167939.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Janux Therapeutics, Inc.</issuerName>
    <cusip>47103J105</cusip>
    <isin>US47103J1051</isin>
    <meetingDate>06/11/2025</meetingDate>
    <voteDescription>To elect the three nominees for Class I director named in the accompanying proxy statement to serve for three-year terms until the 2028 Annual Meeting of Stockholders: Ronald Barrett, Ph.D.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>153551.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>WITHHOLD</howVoted>
        <sharesVoted>153551.000000</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Janux Therapeutics, Inc.</issuerName>
    <cusip>47103J105</cusip>
    <isin>US47103J1051</isin>
    <meetingDate>06/11/2025</meetingDate>
    <voteDescription>To elect the three nominees for Class I director named in the accompanying proxy statement to serve for three-year terms until the 2028 Annual Meeting of Stockholders: David Campbell, Ph.D.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>153551.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>153551.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Janux Therapeutics, Inc.</issuerName>
    <cusip>47103J105</cusip>
    <isin>US47103J1051</isin>
    <meetingDate>06/11/2025</meetingDate>
    <voteDescription>To elect the three nominees for Class I director named in the accompanying proxy statement to serve for three-year terms until the 2028 Annual Meeting of Stockholders: Winston Kung</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>153551.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>WITHHOLD</howVoted>
        <sharesVoted>153551.000000</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Janux Therapeutics, Inc.</issuerName>
    <cusip>47103J105</cusip>
    <isin>US47103J1051</isin>
    <meetingDate>06/11/2025</meetingDate>
    <voteDescription>To ratify the selection by the Audit Committee of the Board of Directors of Ernst &amp; Young LLP as our independent registered public accounting firm for our fiscal year ending December 31, 2025.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>AUDIT-RELATED</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>153551.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>153551.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Janux Therapeutics, Inc.</issuerName>
    <cusip>47103J105</cusip>
    <isin>US47103J1051</isin>
    <meetingDate>06/11/2025</meetingDate>
    <voteDescription>Approval, on an advisory basis, of the compensation of our named executive officers (&quot;Say-On-Pay&quot;), as disclosed in the accompanying Proxy Statement.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>153551.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>AGAINST</howVoted>
        <sharesVoted>153551.000000</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Janux Therapeutics, Inc.</issuerName>
    <cusip>47103J105</cusip>
    <isin>US47103J1051</isin>
    <meetingDate>06/11/2025</meetingDate>
    <voteDescription>Indication, on an advisory basis, of the preferred frequency of holding future Say-On-Pay votes on the compensation of our named executive officers.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>153551.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>ONE YEAR</howVoted>
        <sharesVoted>153551.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Mural Oncology plc</issuerName>
    <cusip>G63365103</cusip>
    <isin>IE000LK2BOB4</isin>
    <meetingDate>06/11/2025</meetingDate>
    <voteDescription>To elect, by separate resolutions, the following six director nominees named in this proxy statement to the board of directors, to serve until the Company's 2026 annual general meeting: Francis Cuss</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>17390.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>17390.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Mural Oncology plc</issuerName>
    <cusip>G63365103</cusip>
    <isin>IE000LK2BOB4</isin>
    <meetingDate>06/11/2025</meetingDate>
    <voteDescription>To elect, by separate resolutions, the following six director nominees named in this proxy statement to the board of directors, to serve until the Company's 2026 annual general meeting: George Golumbeski</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>17390.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>17390.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Mural Oncology plc</issuerName>
    <cusip>G63365103</cusip>
    <isin>IE000LK2BOB4</isin>
    <meetingDate>06/11/2025</meetingDate>
    <voteDescription>To elect, by separate resolutions, the following six director nominees named in this proxy statement to the board of directors, to serve until the Company's 2026 annual general meeting: Benjamin Hickey</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>17390.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>17390.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Mural Oncology plc</issuerName>
    <cusip>G63365103</cusip>
    <isin>IE000LK2BOB4</isin>
    <meetingDate>06/11/2025</meetingDate>
    <voteDescription>To elect, by separate resolutions, the following six director nominees named in this proxy statement to the board of directors, to serve until the Company's 2026 annual general meeting: Scott Jackson</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>17390.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>17390.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Mural Oncology plc</issuerName>
    <cusip>G63365103</cusip>
    <isin>IE000LK2BOB4</isin>
    <meetingDate>06/11/2025</meetingDate>
    <voteDescription>To elect, by separate resolutions, the following six director nominees named in this proxy statement to the board of directors, to serve until the Company's 2026 annual general meeting: Caroline Loew</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>17390.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>17390.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Mural Oncology plc</issuerName>
    <cusip>G63365103</cusip>
    <isin>IE000LK2BOB4</isin>
    <meetingDate>06/11/2025</meetingDate>
    <voteDescription>To elect, by separate resolutions, the following six director nominees named in this proxy statement to the board of directors, to serve until the Company's 2026 annual general meeting: Sachiyo Minegishi</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>17390.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>17390.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Mural Oncology plc</issuerName>
    <cusip>G63365103</cusip>
    <isin>IE000LK2BOB4</isin>
    <meetingDate>06/11/2025</meetingDate>
    <voteDescription>To ratify, in a non-binding advisory vote, the selection of PricewaterhouseCoopers LLP as the Company's independent auditor for the fiscal year ending December 31, 2025 and to authorize, in a binding vote, the board of directors, acting through the audit committee, to set the independent auditor's remuneration;</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>AUDIT-RELATED</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>17390.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>17390.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>uniQure N.V.</issuerName>
    <cusip>N90064101</cusip>
    <isin>NL0010696654</isin>
    <meetingDate>06/11/2025</meetingDate>
    <voteDescription>Adoption of the 2024 Dutch statutory annual accounts for the fiscal year ended December 31, 2024.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>CORPORATE GOVERNANCE</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>1461717.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>1461717.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>uniQure N.V.</issuerName>
    <cusip>N90064101</cusip>
    <isin>NL0010696654</isin>
    <meetingDate>06/11/2025</meetingDate>
    <voteDescription>Discharge of liability of the members of the Board for their management during the fiscal year ended December 31, 2024.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>CORPORATE GOVERNANCE</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>1461717.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>1461717.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>uniQure N.V.</issuerName>
    <cusip>N90064101</cusip>
    <isin>NL0010696654</isin>
    <meetingDate>06/11/2025</meetingDate>
    <voteDescription>Reappointment of Robert Gut, M.D., Ph.D. as non-executive director.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>1461717.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>1461717.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>uniQure N.V.</issuerName>
    <cusip>N90064101</cusip>
    <isin>NL0010696654</isin>
    <meetingDate>06/11/2025</meetingDate>
    <voteDescription>Reappointment of Matthew Kapusta as executive director.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>1461717.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>1461717.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>uniQure N.V.</issuerName>
    <cusip>N90064101</cusip>
    <isin>NL0010696654</isin>
    <meetingDate>06/11/2025</meetingDate>
    <voteDescription>Reappointment of Jeremy Springhorn, Ph.D. as non-executive director.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>1461717.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>1461717.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>uniQure N.V.</issuerName>
    <cusip>N90064101</cusip>
    <isin>NL0010696654</isin>
    <meetingDate>06/11/2025</meetingDate>
    <voteDescription>Authorization of the Board to issue Ordinary Shares and grant rights to subscribe for Ordinary Shares.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>CAPITAL STRUCTURE</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>1461717.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>1461717.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>uniQure N.V.</issuerName>
    <cusip>N90064101</cusip>
    <isin>NL0010696654</isin>
    <meetingDate>06/11/2025</meetingDate>
    <voteDescription>Authorization of the Board to exclude or limit preemptive rights upon the issuance of Ordinary Shares.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>CAPITAL STRUCTURE</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>1461717.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>1461717.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>uniQure N.V.</issuerName>
    <cusip>N90064101</cusip>
    <isin>NL0010696654</isin>
    <meetingDate>06/11/2025</meetingDate>
    <voteDescription>Authorization of the Board to repurchase Ordinary Shares.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>CAPITAL STRUCTURE</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>1461717.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>1461717.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>uniQure N.V.</issuerName>
    <cusip>N90064101</cusip>
    <isin>NL0010696654</isin>
    <meetingDate>06/11/2025</meetingDate>
    <voteDescription>Appointment of KPMG as external auditor of the Company for the financial year 2025.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>AUDIT-RELATED</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>1461717.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>1461717.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>uniQure N.V.</issuerName>
    <cusip>N90064101</cusip>
    <isin>NL0010696654</isin>
    <meetingDate>06/11/2025</meetingDate>
    <voteDescription>Approval, on an advisory basis, of the compensation of the named executive officers of the Company.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>1461717.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>1461717.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>uniQure N.V.</issuerName>
    <cusip>N90064101</cusip>
    <isin>NL0010696654</isin>
    <meetingDate>06/11/2025</meetingDate>
    <voteDescription>Resolution to adopt the Amendment and Restatement of the 2014 Share Incentive Plan.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>COMPENSATION</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>1461717.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>1461717.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Arcutis Biotherapeutics, Inc.</issuerName>
    <cusip>03969K108</cusip>
    <isin>US03969K1088</isin>
    <meetingDate>06/12/2025</meetingDate>
    <voteDescription>Election of Class II directors to hold office until the 2028 Annual Meeting of Stockholders or until their successors are elected: Bhaskar Chaudhuri, Ph.D.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>456927.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>WITHHOLD</howVoted>
        <sharesVoted>456927.000000</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Arcutis Biotherapeutics, Inc.</issuerName>
    <cusip>03969K108</cusip>
    <isin>US03969K1088</isin>
    <meetingDate>06/12/2025</meetingDate>
    <voteDescription>Election of Class II directors to hold office until the 2028 Annual Meeting of Stockholders or until their successors are elected: Sue-Jean Lin</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>456927.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>WITHHOLD</howVoted>
        <sharesVoted>456927.000000</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Arcutis Biotherapeutics, Inc.</issuerName>
    <cusip>03969K108</cusip>
    <isin>US03969K1088</isin>
    <meetingDate>06/12/2025</meetingDate>
    <voteDescription>Election of Class II directors to hold office until the 2028 Annual Meeting of Stockholders or until their successors are elected: Howard G. Welgus, M.D.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>456927.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>WITHHOLD</howVoted>
        <sharesVoted>456927.000000</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Arcutis Biotherapeutics, Inc.</issuerName>
    <cusip>03969K108</cusip>
    <isin>US03969K1088</isin>
    <meetingDate>06/12/2025</meetingDate>
    <voteDescription>To ratify the selection, by the Audit Committee of the Company's Board of Directors, of Ernst &amp; Young LLP, as the independent registered public accounting firm of the Company for its fiscal year ending December 31, 2025.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>AUDIT-RELATED</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>456927.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>456927.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Arcutis Biotherapeutics, Inc.</issuerName>
    <cusip>03969K108</cusip>
    <isin>US03969K1088</isin>
    <meetingDate>06/12/2025</meetingDate>
    <voteDescription>To approve, on a non-binding advisory basis, the compensation of the Company's named executive officers.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>456927.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>AGAINST</howVoted>
        <sharesVoted>456927.000000</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Sionna Therapeutics, Inc.</issuerName>
    <cusip>829401108</cusip>
    <isin>US8294011080</isin>
    <meetingDate>06/12/2025</meetingDate>
    <voteDescription>To elect three class I directors to serve until our 2028 annual meeting of stockholders and until his or her successor has been duly elected and qualified, or until his or her earlier death, resignation or removal: Joshua Resnick, M.D., M.B.A.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
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    <voteDescription>Conduct an advisory vote on the frequency of future advisory votes on the compensation of our named executive officers.</voteDescription>
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    <voteDescription>Election of Directors: Michael S. Brown, M.D.</voteDescription>
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    <voteDescription>Election of Directors: Leonard S. Schleifer, M.D., Ph.D.</voteDescription>
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    <voteDescription>Ratification of the appointment of PricewaterhouseCoopers LLP as the Company's independent registered public accounting firm for the fiscal year ending December 31, 2025.</voteDescription>
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    <voteDescription>Election of Directors: John B. Landis, Ph.D.</voteDescription>
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    <voteDescription>Election of Directors: Stuart Duty</voteDescription>
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    <voteDescription>Election of Directors: Fred Hassan</voteDescription>
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    <voteDescription>Election of Directors: Reginald Sanders, M.D.</voteDescription>
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    <voteDescription>To approve, on an advisory basis, the compensation paid to the Company's named executive officers as disclosed in the accompanying proxy statement.</voteDescription>
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      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
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    <voteDescription>To vote, on an advisory basis, on the frequency of advisory stockholder votes on the compensation paid to our named executive officers.</voteDescription>
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      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
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    <voteDescription>To ratify the appointment of Deloitte &amp; Touche LLP as the Company's independent registered public accounting firm for the fiscal year ending December 31, 2025.</voteDescription>
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      <voteCategory>
        <categoryType>AUDIT-RELATED</categoryType>
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    <voteDescription>Election of Class I Directors: Vijaya Gadde</voteDescription>
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      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
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    <sharesVoted>60643.000000</sharesVoted>
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    <voteDescription>Election of Class I Directors: Musa Tariq</voteDescription>
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      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
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    <voteDescription>Ratification of the appointment of Deloitte &amp; Touche LLP as Guardant Health, Inc.'s independent registered public accounting firm for the year ending December 31, 2025.</voteDescription>
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      <voteCategory>
        <categoryType>AUDIT-RELATED</categoryType>
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    <voteDescription>Non-binding advisory vote to approve Guardant Health, Inc.'s named executive officer compensation.</voteDescription>
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      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
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    <voteDescription>Election of the following nominees as Class I directors: Grant Bogle</voteDescription>
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      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
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        <managementRecommendation>FOR</managementRecommendation>
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    <voteDescription>Election of the following nominees as Class I directors: Anna Protopapas</voteDescription>
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        <categoryType>DIRECTOR ELECTIONS</categoryType>
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        <sharesVoted>42867.000000</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
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    <voteDescription>To approve, on an advisory basis, the compensation paid to our named executive officers.</voteDescription>
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      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
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    <voteDescription>To ratify the appointment of KPMG LLP as Nuvalent, Inc.'s independent registered public accounting firm for the fiscal year ending December 31, 2025.</voteDescription>
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      <voteCategory>
        <categoryType>AUDIT-RELATED</categoryType>
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        <managementRecommendation>FOR</managementRecommendation>
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    <isin>US7473241013</isin>
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    <voteDescription>The election of Class I directors named in the proxy statement: Santhosh Palani, Ph.D., CFA</voteDescription>
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      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
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        <sharesVoted>626637.000000</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
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        <categoryType>DIRECTOR ELECTIONS</categoryType>
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    <voteDescription>The ratification of the appointment of Ernst &amp; Young LLP as the company's independent registered public accounting firm for the fiscal year ending December 31, 2025;</voteDescription>
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        <categoryType>AUDIT-RELATED</categoryType>
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        <categoryType>DIRECTOR ELECTIONS</categoryType>
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    <voteDescription>Election of three Class III directors to serve on the board of directors, each for a three-year term expiring at the 2028 Annual Meeting of Stockholders: John W. Shiver, Ph.D.</voteDescription>
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        <categoryType>DIRECTOR ELECTIONS</categoryType>
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    <voteDescription>Election of three Class III directors to serve on the board of directors, each for a three-year term expiring at the 2028 Annual Meeting of Stockholders: Charles W. Newton</voteDescription>
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    <meetingDate>06/20/2025</meetingDate>
    <voteDescription>The approval, on an advisory basis, of the compensation paid of our Named Executive Officers.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>37188.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>37188.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Novavax, Inc.</issuerName>
    <cusip>670002401</cusip>
    <isin>US6700024010</isin>
    <meetingDate>06/20/2025</meetingDate>
    <voteDescription>Ratification of the appointment of Ernst &amp; Young LLP as our independent registered public accounting firm for the fiscal year ending December 31, 2025.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>AUDIT-RELATED</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>37188.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>37188.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Structure Therapeutics Inc.</issuerName>
    <cusip>86366E106</cusip>
    <isin>US86366E1064</isin>
    <meetingDate>06/23/2025</meetingDate>
    <voteDescription>Election of the nominees for Class II director named below to hold office until the 2028 annual general meeting of shareholders and their successors are duly elected and qualified, or until their earlier death, resignation or removal: Eric Dobmeier</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>169939.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>169939.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Structure Therapeutics Inc.</issuerName>
    <cusip>86366E106</cusip>
    <isin>US86366E1064</isin>
    <meetingDate>06/23/2025</meetingDate>
    <voteDescription>Election of the nominees for Class II director named below to hold office until the 2028 annual general meeting of shareholders and their successors are duly elected and qualified, or until their earlier death, resignation or removal: Joanne Waldstreicher, M.D.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>169939.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>169939.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Structure Therapeutics Inc.</issuerName>
    <cusip>86366E106</cusip>
    <isin>US86366E1064</isin>
    <meetingDate>06/23/2025</meetingDate>
    <voteDescription>To ratify the appointment by the Audit Committee of the Board of Directors of Ernst &amp; Young LLP as the Company's independent registered public accounting firm for the fiscal year ending December 31, 2025.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>AUDIT-RELATED</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>169939.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>169939.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Structure Therapeutics Inc.</issuerName>
    <cusip>86366E106</cusip>
    <isin>US86366E1064</isin>
    <meetingDate>06/23/2025</meetingDate>
    <voteDescription>To approve, on an advisory basis, the compensation of the Company's named executive officers, as disclosed in the proxy statement.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>169939.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>169939.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Structure Therapeutics Inc.</issuerName>
    <cusip>86366E106</cusip>
    <isin>US86366E1064</isin>
    <meetingDate>06/23/2025</meetingDate>
    <voteDescription>To indicate, on an advisory basis, the preferred frequency of shareholder advisory votes on the compensation of the Company's named executive officers.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>169939.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>ONE YEAR</howVoted>
        <sharesVoted>169939.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>IDEAYA Biosciences, Inc.</issuerName>
    <cusip>45166A102</cusip>
    <isin>US45166A1025</isin>
    <meetingDate>06/24/2025</meetingDate>
    <voteDescription>To elect two Class III directors to hold office until the 2028 annual meeting of stockholders or until their successors are elected: Jeffery L. Stein. Ph.D.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>286579.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>286579.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>IDEAYA Biosciences, Inc.</issuerName>
    <cusip>45166A102</cusip>
    <isin>US45166A1025</isin>
    <meetingDate>06/24/2025</meetingDate>
    <voteDescription>To elect two Class III directors to hold office until the 2028 annual meeting of stockholders or until their successors are elected: Scott W. Morrison</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>286579.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>WITHHOLD</howVoted>
        <sharesVoted>286579.000000</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>IDEAYA Biosciences, Inc.</issuerName>
    <cusip>45166A102</cusip>
    <isin>US45166A1025</isin>
    <meetingDate>06/24/2025</meetingDate>
    <voteDescription>To ratify the selection, by the Audit Committee of the Company's Board of Directors, of PricewaterhouseCoopers LLP, as the independent registered public accounting firm of the Company for its fiscal year ending December 31, 2025;</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>AUDIT-RELATED</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>286579.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>286579.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>IDEAYA Biosciences, Inc.</issuerName>
    <cusip>45166A102</cusip>
    <isin>US45166A1025</isin>
    <meetingDate>06/24/2025</meetingDate>
    <voteDescription>To approve, on a non-binding, advisory basis, the compensation of the Company's named executive officers as disclosed in the Proxy Statement accompanying this Notice of Annual Meeting of Stockholders.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>286579.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>286579.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Rhythm Pharmaceuticals, Inc.</issuerName>
    <cusip>76243J105</cusip>
    <isin>US76243J1051</isin>
    <meetingDate>06/24/2025</meetingDate>
    <voteDescription>Election of the Class II directors, each to serve for a three year term until the 2028 Annual Meeting of Stockholders and until their respective successors are duly elected and qualified: Jennifer Good</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>52675.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>52675.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Rhythm Pharmaceuticals, Inc.</issuerName>
    <cusip>76243J105</cusip>
    <isin>US76243J1051</isin>
    <meetingDate>06/24/2025</meetingDate>
    <voteDescription>Election of the Class II directors, each to serve for a three year term until the 2028 Annual Meeting of Stockholders and until their respective successors are duly elected and qualified: Edward T. Mathers</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>52675.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>WITHHOLD</howVoted>
        <sharesVoted>52675.000000</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Rhythm Pharmaceuticals, Inc.</issuerName>
    <cusip>76243J105</cusip>
    <isin>US76243J1051</isin>
    <meetingDate>06/24/2025</meetingDate>
    <voteDescription>Ratification of the appointment of Ernst &amp; Young LLP as the independent registered public accounting firm for the Company for the fiscal year ending December 31, 2025.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>AUDIT-RELATED</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>52675.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>52675.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Rhythm Pharmaceuticals, Inc.</issuerName>
    <cusip>76243J105</cusip>
    <isin>US76243J1051</isin>
    <meetingDate>06/24/2025</meetingDate>
    <voteDescription>Approval, on an advisory (non-binding) basis, of the compensation of the named executive officers of the Company.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>52675.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>52675.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Rhythm Pharmaceuticals, Inc.</issuerName>
    <cusip>76243J105</cusip>
    <isin>US76243J1051</isin>
    <meetingDate>06/24/2025</meetingDate>
    <voteDescription>Approval of an amendment to our Amended and Restated Certificate of Incorporation to provide for exculpation of officers from breaches of fiduciary duty to the fullest extent permitted by the General Corporation Law of the State of Delaware (the &quot;Officer Exculpation Proposal&quot;).</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>CORPORATE GOVERNANCE</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>52675.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>52675.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Rhythm Pharmaceuticals, Inc.</issuerName>
    <cusip>76243J105</cusip>
    <isin>US76243J1051</isin>
    <meetingDate>06/24/2025</meetingDate>
    <voteDescription>Approval of an adjournment of the Annual Meeting, if necessary, to solicit additional proxies if there are not sufficient votes at the time of the Annual Meeting to approve the Officer Exculpation Amendment.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>CORPORATE GOVERNANCE</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>52675.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>52675.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>ARS Pharmaceuticals, Inc.</issuerName>
    <cusip>82835W108</cusip>
    <isin>US82835W1080</isin>
    <meetingDate>06/25/2025</meetingDate>
    <voteDescription>To elect the four nominees for Class II director named in the proxy statement to serve for three-year terms until the 2028 Annual Meeting of Stockholders: Richard Lowenthal</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>507222.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>507222.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>ARS Pharmaceuticals, Inc.</issuerName>
    <cusip>82835W108</cusip>
    <isin>US82835W1080</isin>
    <meetingDate>06/25/2025</meetingDate>
    <voteDescription>To elect the four nominees for Class II director named in the proxy statement to serve for three-year terms until the 2028 Annual Meeting of Stockholders: Peter Kolchinsky</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>507222.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>WITHHOLD</howVoted>
        <sharesVoted>507222.000000</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>ARS Pharmaceuticals, Inc.</issuerName>
    <cusip>82835W108</cusip>
    <isin>US82835W1080</isin>
    <meetingDate>06/25/2025</meetingDate>
    <voteDescription>To elect the four nominees for Class II director named in the proxy statement to serve for three-year terms until the 2028 Annual Meeting of Stockholders: Brenton L. Saunders</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>507222.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>WITHHOLD</howVoted>
        <sharesVoted>507222.000000</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>ARS Pharmaceuticals, Inc.</issuerName>
    <cusip>82835W108</cusip>
    <isin>US82835W1080</isin>
    <meetingDate>06/25/2025</meetingDate>
    <voteDescription>To elect the four nominees for Class II director named in the proxy statement to serve for three-year terms until the 2028 Annual Meeting of Stockholders: Peter A. Thompson</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>507222.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>WITHHOLD</howVoted>
        <sharesVoted>507222.000000</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>ARS Pharmaceuticals, Inc.</issuerName>
    <cusip>82835W108</cusip>
    <isin>US82835W1080</isin>
    <meetingDate>06/25/2025</meetingDate>
    <voteDescription>To ratify the selection by the Audit Committee of the Board of Directors of Ernst &amp; Young LLP as our independent registered public accounting firm for our fiscal year ending December 31, 2025.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>AUDIT-RELATED</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>507222.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>507222.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Praxis Precision Medicines, Inc.</issuerName>
    <cusip>74006W207</cusip>
    <isin>US74006W2070</isin>
    <meetingDate>06/26/2025</meetingDate>
    <voteDescription>To elect the Class II Directors to serve until the 2028 Annual Meeting of Stockholders and until their respective successors have been duly elected and qualified: Jeffrey Chodakewitz, M.D.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>105047.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>WITHHOLD</howVoted>
        <sharesVoted>105047.000000</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Praxis Precision Medicines, Inc.</issuerName>
    <cusip>74006W207</cusip>
    <isin>US74006W2070</isin>
    <meetingDate>06/26/2025</meetingDate>
    <voteDescription>To elect the Class II Directors to serve until the 2028 Annual Meeting of Stockholders and until their respective successors have been duly elected and qualified: Merit Cudkowicz, M.D.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>105047.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>105047.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Praxis Precision Medicines, Inc.</issuerName>
    <cusip>74006W207</cusip>
    <isin>US74006W2070</isin>
    <meetingDate>06/26/2025</meetingDate>
    <voteDescription>To ratify the selection of Ernst &amp; Young LLP as the Company's independent registered public accounting firm for the fiscal year ending December 31, 2025.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>AUDIT-RELATED</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>105047.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>105047.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Praxis Precision Medicines, Inc.</issuerName>
    <cusip>74006W207</cusip>
    <isin>US74006W2070</isin>
    <meetingDate>06/26/2025</meetingDate>
    <voteDescription>To approve, on an advisory (non-binding) basis, the compensation of the named executive officers as disclosed in the Company's proxy statement for the 2025 Annual Meeting of Stockholders pursuant to the applicable compensation disclosure rules of the SEC, including the compensation tables and narrative discussion.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>105047.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>AGAINST</howVoted>
        <sharesVoted>105047.000000</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>TScan Therapeutics, Inc.</issuerName>
    <cusip>89854M101</cusip>
    <isin>US89854M1018</isin>
    <meetingDate>06/30/2025</meetingDate>
    <voteDescription>To elect three Class I directors to the Company's Board of Directors: Stephen Biggar</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>DIRECTOR ELECTIONS</categoryType>
      </voteCategory>
    </voteCategories>
    <voteSource>ISSUER</voteSource>
    <sharesVoted>498008.000000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>498008.000000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>TScan Therapeutics, Inc.</issuerName>
    <cusip>89854M101</cusip>
    <isin>US89854M1018</isin>
    <meetingDate>06/30/2025</meetingDate>
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