<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019c4b92-e6b4-759a-82df-dd3d13b16996,g:407da955-1d3a-4833-a65f-0d5d89eb1dcf-->
<xs:schema xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:qcom="http://www.qualcomm.com/20260329" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:dtr-types="http://www.xbrl.org/dtr/type/2024-01-31" attributeFormDefault="unqualified" elementFormDefault="qualified" targetNamespace="http://www.qualcomm.com/20260329">
  <xs:import namespace="http://fasb.org/srt/2025" schemaLocation="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd"/>
  <xs:import namespace="http://fasb.org/us-gaap/2025" schemaLocation="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd"/>
  <xs:import namespace="http://www.xbrl.org/2003/instance" schemaLocation="http://www.xbrl.org/2003/xbrl-instance-2003-12-31.xsd"/>
  <xs:import namespace="http://www.xbrl.org/2003/linkbase" schemaLocation="http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd"/>
  <xs:import namespace="http://www.xbrl.org/dtr/type/2024-01-31" schemaLocation="https://www.xbrl.org/dtr/type/2024-01-31/types.xsd"/>
  <xs:import namespace="http://xbrl.sec.gov/dei/2025" schemaLocation="https://xbrl.sec.gov/dei/2025/dei-2025.xsd"/>
  <xs:import namespace="http://xbrl.sec.gov/ecd/2025" schemaLocation="https://xbrl.sec.gov/ecd/2025/ecd-2025.xsd"/>
  <xs:annotation>
    <xs:appinfo>
      <link:linkbaseRef xmlns:xlink="http://www.w3.org/1999/xlink" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="qcom-20260329_pre.xml" xlink:role="http://www.xbrl.org/2003/role/presentationLinkbaseRef" xlink:type="simple"/>
      <link:linkbaseRef xmlns:xlink="http://www.w3.org/1999/xlink" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="qcom-20260329_def.xml" xlink:role="http://www.xbrl.org/2003/role/definitionLinkbaseRef" xlink:type="simple"/>
      <link:linkbaseRef xmlns:xlink="http://www.w3.org/1999/xlink" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="qcom-20260329_lab.xml" xlink:role="http://www.xbrl.org/2003/role/labelLinkbaseRef" xlink:type="simple"/>
      <link:linkbaseRef xmlns:xlink="http://www.w3.org/1999/xlink" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="qcom-20260329_cal.xml" xlink:role="http://www.xbrl.org/2003/role/calculationLinkbaseRef" xlink:type="simple"/>
      <link:roleType id="CoverPage" roleURI="http://www.qualcomm.com/role/CoverPage">
        <link:definition>0000001 - Document - Cover Page</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CONDENSEDCONSOLIDATEDBALANCESHEETS" roleURI="http://www.qualcomm.com/role/CONDENSEDCONSOLIDATEDBALANCESHEETS">
        <link:definition>9952151 - Statement - CONDENSED CONSOLIDATED BALANCE SHEETS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONS" roleURI="http://www.qualcomm.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONS">
        <link:definition>9952152 - Statement - CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CONDENSEDCONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOME" roleURI="http://www.qualcomm.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOME">
        <link:definition>9952153 - Statement - CONDENSED CONSOLIDATED STATEMENTS OF COMPREHENSIVE INCOME</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWS" roleURI="http://www.qualcomm.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWS">
        <link:definition>9952154 - Statement - CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CONDENSEDCONSOLIDATEDSTATEMENTSOFSTOCKHOLDERSEQUITY" roleURI="http://www.qualcomm.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFSTOCKHOLDERSEQUITY">
        <link:definition>9952155 - Statement - CONDENSED CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BasisofPresentationandSignificantAccountingPoliciesUpdate" roleURI="http://www.qualcomm.com/role/BasisofPresentationandSignificantAccountingPoliciesUpdate">
        <link:definition>9952156 - Disclosure - Basis of Presentation and Significant Accounting Policies Update</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CompositionofCertainFinancialStatementItems" roleURI="http://www.qualcomm.com/role/CompositionofCertainFinancialStatementItems">
        <link:definition>9952157 - Disclosure - Composition of Certain Financial Statement Items</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="IncomeTaxes" roleURI="http://www.qualcomm.com/role/IncomeTaxes">
        <link:definition>9952158 - Disclosure - Income Taxes</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CapitalStock" roleURI="http://www.qualcomm.com/role/CapitalStock">
        <link:definition>9952159 - Disclosure - Capital Stock</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CommitmentsandContingencies" roleURI="http://www.qualcomm.com/role/CommitmentsandContingencies">
        <link:definition>9952160 - Disclosure - Commitments and Contingencies</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SegmentInformation" roleURI="http://www.qualcomm.com/role/SegmentInformation">
        <link:definition>9952161 - Disclosure - Segment Information</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FairValueMeasurementsandMarketableSecurities" roleURI="http://www.qualcomm.com/role/FairValueMeasurementsandMarketableSecurities">
        <link:definition>9952162 - Disclosure - Fair Value Measurements and Marketable Securities</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="Acquisitions" roleURI="http://www.qualcomm.com/role/Acquisitions">
        <link:definition>9952163 - Disclosure - Acquisitions</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BasisofPresentationandSignificantAccountingPoliciesUpdatePolicies" roleURI="http://www.qualcomm.com/role/BasisofPresentationandSignificantAccountingPoliciesUpdatePolicies">
        <link:definition>9955511 - Disclosure - Basis of Presentation and Significant Accounting Policies Update (Policies)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CompositionofCertainFinancialStatementItemsTables" roleURI="http://www.qualcomm.com/role/CompositionofCertainFinancialStatementItemsTables">
        <link:definition>9955512 - Disclosure - Composition of Certain Financial Statement Items (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CapitalStockEarningsperCommonShareTables" roleURI="http://www.qualcomm.com/role/CapitalStockEarningsperCommonShareTables">
        <link:definition>9955513 - Disclosure - Capital Stock Earnings per Common Share (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SegmentInformationTables" roleURI="http://www.qualcomm.com/role/SegmentInformationTables">
        <link:definition>9955514 - Disclosure - Segment Information (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FairValueMeasurementsTables" roleURI="http://www.qualcomm.com/role/FairValueMeasurementsTables">
        <link:definition>9955515 - Disclosure - Fair Value Measurements (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="AcquisitionsTables" roleURI="http://www.qualcomm.com/role/AcquisitionsTables">
        <link:definition>9955516 - Disclosure - Acquisitions (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CompositionofCertainFinancialStatementItemsInventoriesDetails" roleURI="http://www.qualcomm.com/role/CompositionofCertainFinancialStatementItemsInventoriesDetails">
        <link:definition>9955517 - Disclosure - Composition of Certain Financial Statement Items Inventories (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CompositionofCertainFinancialStatementItemsOtherAssetsDetails" roleURI="http://www.qualcomm.com/role/CompositionofCertainFinancialStatementItemsOtherAssetsDetails">
        <link:definition>9955518 - Disclosure - Composition of Certain Financial Statement Items Other Assets (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CompositionofCertainFinancialStatementItemsOtherCurrentLiabilitiesDetails" roleURI="http://www.qualcomm.com/role/CompositionofCertainFinancialStatementItemsOtherCurrentLiabilitiesDetails">
        <link:definition>9955519 - Disclosure - Composition of Certain Financial Statement Items Other Current Liabilities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CompositionofCertainFinancialStatementItemsInterestRateSwapsDetails" roleURI="http://www.qualcomm.com/role/CompositionofCertainFinancialStatementItemsInterestRateSwapsDetails">
        <link:definition>9955520 - Disclosure - Composition of Certain Financial Statement Items Interest Rate Swaps (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CompositionofCertainFinancialStatementItemsDebtCreditFacilitiesDetails" roleURI="http://www.qualcomm.com/role/CompositionofCertainFinancialStatementItemsDebtCreditFacilitiesDetails">
        <link:definition>9955521 - Disclosure - Composition of Certain Financial Statement Items Debt Credit Facilities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CompositionofCertainFinancialStatementItemsRevenuesDetails" roleURI="http://www.qualcomm.com/role/CompositionofCertainFinancialStatementItemsRevenuesDetails">
        <link:definition>9955522 - Disclosure - Composition of Certain Financial Statement Items Revenues (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CompositionofCertainFinancialStatementItemsConcentrationsDetails" roleURI="http://www.qualcomm.com/role/CompositionofCertainFinancialStatementItemsConcentrationsDetails">
        <link:definition>9955523 - Disclosure - Composition of Certain Financial Statement Items Concentrations (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CompositionofCertainFinancialStatementItemsOtherIncomeCostsandExpensesDetails" roleURI="http://www.qualcomm.com/role/CompositionofCertainFinancialStatementItemsOtherIncomeCostsandExpensesDetails">
        <link:definition>9955524 - Disclosure - Composition of Certain Financial Statement Items Other Income, Costs and Expenses (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CompositionofCertainFinancialStatementItemsInvestmentandOtherIncomeExpenseNetDetails" roleURI="http://www.qualcomm.com/role/CompositionofCertainFinancialStatementItemsInvestmentandOtherIncomeExpenseNetDetails">
        <link:definition>9955525 - Disclosure - Composition of Certain Financial Statement Items Investment and Other Income (Expense), Net (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="IncomeTaxesDetails" roleURI="http://www.qualcomm.com/role/IncomeTaxesDetails">
        <link:definition>9955526 - Disclosure - Income Taxes (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CapitalStockShareRepurchaseProgramDetails" roleURI="http://www.qualcomm.com/role/CapitalStockShareRepurchaseProgramDetails">
        <link:definition>9955527 - Disclosure - Capital Stock Share Repurchase Program (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CapitalStockSharesOutstandingDetails" roleURI="http://www.qualcomm.com/role/CapitalStockSharesOutstandingDetails">
        <link:definition>9955528 - Disclosure - Capital Stock Shares Outstanding (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CapitalStockDividendsDetails" roleURI="http://www.qualcomm.com/role/CapitalStockDividendsDetails">
        <link:definition>9955529 - Disclosure - Capital Stock Dividends (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CapitalStockEarningsperCommonShareDetails" roleURI="http://www.qualcomm.com/role/CapitalStockEarningsperCommonShareDetails">
        <link:definition>9955530 - Disclosure - Capital Stock Earnings per Common Share (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CommitmentsandContingenciesLegalandRegulatoryProceedingsDetails" roleURI="http://www.qualcomm.com/role/CommitmentsandContingenciesLegalandRegulatoryProceedingsDetails">
        <link:definition>9955531 - Disclosure - Commitments and Contingencies Legal and Regulatory Proceedings (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SegmentInformationDetails" roleURI="http://www.qualcomm.com/role/SegmentInformationDetails">
        <link:definition>9955532 - Disclosure - Segment Information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FairValueMeasurementsFairValueHierarchyDetails" roleURI="http://www.qualcomm.com/role/FairValueMeasurementsFairValueHierarchyDetails">
        <link:definition>9955533 - Disclosure - Fair Value Measurements Fair Value Hierarchy (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FairValueMeasurementsLongtermDebtDetails" roleURI="http://www.qualcomm.com/role/FairValueMeasurementsLongtermDebtDetails">
        <link:definition>9955534 - Disclosure - Fair Value Measurements Long-term Debt (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="MarketableSecuritiesDetails" roleURI="http://www.qualcomm.com/role/MarketableSecuritiesDetails">
        <link:definition>9955535 - Disclosure - Marketable Securities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="AcquisitionsDetails" roleURI="http://www.qualcomm.com/role/AcquisitionsDetails">
        <link:definition>9955536 - Disclosure - Acquisitions (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
    </xs:appinfo>
  </xs:annotation>
  <xs:element id="qcom_EquipmentAndServices" abstract="false" name="EquipmentAndServices" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qcom_LicensingRevenues" abstract="false" name="LicensingRevenues" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qcom_OperatingExpenseTotalAbstract" abstract="true" name="OperatingExpenseTotalAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="qcom_IncomeTaxProvisionLessThanInExcessOfIncomeTaxPayments" abstract="false" name="IncomeTaxProvisionLessThanInExcessOfIncomeTaxPayments" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qcom_AcquisitionsAndOtherInvestmentsNetofCashAcquired" abstract="false" name="AcquisitionsAndOtherInvestmentsNetofCashAcquired" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qcom_BasisofPresentationAbstract" abstract="true" name="BasisofPresentationAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="qcom_FairValueMeasurementsAbstract" abstract="true" name="FairValueMeasurementsAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="qcom_SegmentReportingEBTPolicyPolicyTextBlock" abstract="false" name="SegmentReportingEBTPolicyPolicyTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="qcom_RevenueRecognizedFromPerformanceObligationsSatisfiedInPreviousPeriodsTableTextBlock" abstract="false" name="RevenueRecognizedFromPerformanceObligationsSatisfiedInPreviousPeriodsTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="qcom_CustomerConcentrationsRevenuesTableTextBlock" abstract="false" name="CustomerConcentrationsRevenuesTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="qcom_AdvancePaymentRelatedToMultiYearCapacityCommitments" abstract="false" name="AdvancePaymentRelatedToMultiYearCapacityCommitments" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qcom_HandsetsMember" abstract="true" name="HandsetsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qcom_AutomotiveMember" abstract="true" name="AutomotiveMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qcom_IoTMember" abstract="true" name="IoTMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qcom_QctMember" abstract="true" name="QctMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qcom_PatentLicenseAgreementExpirationPeriod" abstract="false" name="PatentLicenseAgreementExpirationPeriod" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:gYearItemType"/>
  <xs:element id="qcom_CustomerXMember" abstract="true" name="CustomerXMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qcom_CustomerYMember" abstract="true" name="CustomerYMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qcom_CustomerZMember" abstract="true" name="CustomerZMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qcom_NetLossesGainsOnDeferredCompensationPlanAssets" abstract="false" name="NetLossesGainsOnDeferredCompensationPlanAssets" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qcom_ImpairmentLossesOnOtherInvestmentsWithoutReadilyDeterminableFairValue" abstract="false" name="ImpairmentLossesOnOtherInvestmentsWithoutReadilyDeterminableFairValue" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qcom_FDDEIEffectiveTaxRateMember" abstract="true" name="FDDEIEffectiveTaxRateMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qcom_U.S.FederalMember" abstract="true" name="U.S.FederalMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qcom_A20BStockRepurchaseProgramAnnouncedMarch172026Member" abstract="true" name="A20BStockRepurchaseProgramAnnouncedMarch172026Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qcom_A15BStockRepurchaseProgramAnnouncedNovember62024Member" abstract="true" name="A15BStockRepurchaseProgramAnnouncedNovember62024Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qcom_StockRepurchaseProgramsAuthorizedAndRemainingMember" abstract="true" name="StockRepurchaseProgramsAuthorizedAndRemainingMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qcom_SharesOutstandingAbstract" abstract="true" name="SharesOutstandingAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="qcom_AmountOfIncreasedCommonStockDividendsPerShareAnnounced" abstract="false" name="AmountOfIncreasedCommonStockDividendsPerShareAnnounced" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType"/>
  <xs:element id="qcom_QtlMember" abstract="true" name="QtlMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qcom_QsiMember" abstract="true" name="QsiMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qcom_MortgageandassetbackedandauctionratesecuritiesMember" abstract="true" name="MortgageandassetbackedandauctionratesecuritiesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qcom_AlphawaveMember" abstract="true" name="AlphawaveMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qcom_A2026OtherBusinessAcquisitionsMember" abstract="true" name="A2026OtherBusinessAcquisitionsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qcom_ExchangeableSharesMember" abstract="true" name="ExchangeableSharesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qcom_DataCenterOperatingSegmentMember" abstract="true" name="DataCenterOperatingSegmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qcom_BusinessCombinationRecognizedAssetAcquiredOtherAssetCurrentAndNoncurrent" abstract="false" name="BusinessCombinationRecognizedAssetAcquiredOtherAssetCurrentAndNoncurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qcom_BusinessCombinationRecognizedLiabilityAssumedOtherLiabilityCurrentAndNoncurrent" abstract="false" name="BusinessCombinationRecognizedLiabilityAssumedOtherLiabilityCurrentAndNoncurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qcom_ExchangeableSharesIssuedFairValue" abstract="false" name="ExchangeableSharesIssuedFairValue" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qcom_AnnChaplinMember" abstract="true" name="AnnChaplinMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
</xs:schema>
