<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/schedule13g" xmlns:ns2="http://www.sec.gov/edgar/common">
    <schemaVersion>X0202</schemaVersion>
<headerData>
        <submissionType>SCHEDULE 13G/A</submissionType>
        <previousAccessionNumber>0001897612-24-001393</previousAccessionNumber>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0000080255</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>


        </filerInfo>
    </headerData>
    <formData>
        <coverPageHeader>
            <amendmentNo>2</amendmentNo>
            <securitiesClassTitle>COMMON STOCK</securitiesClassTitle>
            <eventDateRequiresFilingThisStatement>04/30/2026</eventDateRequiresFilingThisStatement>
            <issuerInfo>
                <issuerCik>0000034956</issuerCik>
                <issuerName>TENAX THERAPEUTICS INC</issuerName>
                <issuerCusips>
                    <issuerCusipNumber>88032L605</issuerCusipNumber>
                </issuerCusips>
                <issuerPrincipalExecutiveOfficeAddress>
                    <ns2:street1>101 GLEN LENNOX DRIVE</ns2:street1>
                    <ns2:street2>SUITE 300</ns2:street2>
                    <ns2:city>CHAPEL HILL</ns2:city>
                    <ns2:stateOrCountry>NC</ns2:stateOrCountry>
                    <ns2:zipCode>27517</ns2:zipCode>
                </issuerPrincipalExecutiveOfficeAddress>
            </issuerInfo>
            <designateRulesPursuantThisScheduleFiled>
                <designateRulePursuantThisScheduleFiled>Rule 13d-1(b)</designateRulePursuantThisScheduleFiled>
            </designateRulesPursuantThisScheduleFiled>
        </coverPageHeader>
        <coverPageHeaderReportingPersonDetails>

            <reportingPersonName>T. Rowe Price Associates, Inc.</reportingPersonName>
            <citizenshipOrOrganization>MD</citizenshipOrOrganization>
            <reportingPersonBeneficiallyOwnedNumberOfShares>
                <soleVotingPower>2841114</soleVotingPower>
                <sharedVotingPower>0</sharedVotingPower>
                <soleDispositivePower>2841114</soleDispositivePower>
                <sharedDispositivePower>0</sharedDispositivePower>
            </reportingPersonBeneficiallyOwnedNumberOfShares>
            <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>2841114</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
            <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
            <classPercent>11.0</classPercent>
            <typeOfReportingPerson>IA</typeOfReportingPerson>
        </coverPageHeaderReportingPersonDetails>
        <items>
            <item1>
                <issuerName>TENAX THERAPEUTICS INC</issuerName>
                <issuerPrincipalExecutiveOfficeAddress>101 GLEN LENNOX DRIVE, SUITE 300, CHAPEL HILL, NC, 27517</issuerPrincipalExecutiveOfficeAddress>
            </item1>
            <item2>
                <filingPersonName>T. Rowe Price Associates, Inc.</filingPersonName>
                <principalBusinessOfficeOrResidenceAddress>1307 Point Street, Baltimore, MD 21231</principalBusinessOfficeOrResidenceAddress>
                <citizenship>Maryland</citizenship>
            </item2>
            <item3>
                <notApplicableFlag>N</notApplicableFlag>
                <typeOfPersonFiling>IA</typeOfPersonFiling>
            </item3>
            <item4>
                <amountBeneficiallyOwned>2841114</amountBeneficiallyOwned>
                <classPercent>11.0</classPercent>
                <numberOfSharesPersonHas>
                    <solePowerOrDirectToVote>2841114</solePowerOrDirectToVote>
                    <sharedPowerOrDirectToVote>0</sharedPowerOrDirectToVote>
                    <solePowerOrDirectToDispose>2841114</solePowerOrDirectToDispose>
                    <sharedPowerOrDirectToDispose>0</sharedPowerOrDirectToDispose>
                </numberOfSharesPersonHas>
            </item4>
            <item5>
                <notApplicableFlag>Y</notApplicableFlag>
            </item5>
            <item6>
                <notApplicableFlag>N</notApplicableFlag>
                <ownershipMoreThan5PercentOnBehalfOfAnotherPerson>Ownership of More than Five Percent on Behalf of Another Person (1)   Price Associates does not serve as custodian of the assets of any of its clients; accordingly, in each instance only the client or the client's custodian or trustee bank has the right to receive dividends paid with respect to, and proceeds from the sale of, such securities. The ultimate power to direct the receipt of dividends paid with respect to, and the proceeds from the sale of, such securities, is vested in the individual and institutional clients which Price Associates serves as investment adviser. Any and all discretionary authority which has been delegated to Price Associates may be revoked in whole or in part at any time. Except as may be indicated if this is a joint filing with one of the registered investment companies sponsored by Price Associates which it also serves as investment adviser ("T. Rowe Price Funds"), not more than 5% of the class of such securities is owned by any one client subject to the investment advice of Price Associates.  (2)     [T. ROWE PRICE HEALTH SCIENCES FUND ]:  T. ROWE PRICE HEALTH SCIENCES FUND, of which T. Rowe Price Associates, Inc. is the investment adviser, holds the securities reported herein in their investment portfolio managed by T. Rowe Price Associates, Inc. and such funds have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, the securities that they hold. T. ROWE PRICE HEALTH SCIENCES FUND has an interest in 2,381,762 of the class reported herein representing 9.2% of the class.  </ownershipMoreThan5PercentOnBehalfOfAnotherPerson>
            </item6>
            <item7>
                <notApplicableFlag>Y</notApplicableFlag>
            </item7>
            <item8>
                <notApplicableFlag>Y</notApplicableFlag>
            </item8>
            <item9>
                <notApplicableFlag>Y</notApplicableFlag>
            </item9>
            <item10>
                <notApplicableFlag>N</notApplicableFlag>
                <certifications>By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. T. Rowe Price Associates, Inc. hereby declares and affirms that the filing of Schedule 13G shall not be construed as an admission that Price Associates is the beneficial owner of the securities referred to, which beneficial ownership is expressly denied.</certifications>
            </item10>
        </items>
        <signatureInformation>
            <reportingPersonName>T. Rowe Price Associates, Inc.</reportingPersonName>
            <signatureDetails>
                <signature>Ellen York</signature>
                <title>Vice President</title>
                <date>05/07/2026</date>
            </signatureDetails>
        </signatureInformation>
    </formData>
</edgarSubmission>
