Note 8 - Stock-Based Compensation (Details) - USD ($)	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014
Disclosure of Compensation Related Costs, Share-based Payments [Abstract]
Options Outstanding	67,434	82,336
Option Granted	1,683	13,159
Option Cancelled	(1,238)	(28,061)
Options Outstanding	67,879	67,434
Options exercisable at End	66,270
Outstanding at Beginning, Weighted-Average Exercise Price	$ 26.26	$ 42.42
Weighted- Average Exercise Price, Granted	2.08	21.21
Weighted- Average Exercise Price, Cancelled	18.79	46.46
Outstanding at Ending, Weighted-Average Exercise Price	21.40	$ 26.26
Weighted- Average exercisable at End	$ 36.70
Weighted- Average Remaining Contractual Term, Beginning balance	8 years 1 month 10 days	9 years 1 month 2 days
Weighted- Average Remaining Contractual Term, Granted	9 years 2 months 5 days	9 years 1 month 10 days
Weighted- Average Remaining Contractual Term, Ending Balance	7 years 2 months 1 day	8 years 1 month 10 days
Weighted- Average Remaining Contractual Term, exercisable at End	6 years 9 months 15 days
Aggregate Intrinsic Value	$ 0	$ 0
Aggregate Intrinsic Value, exercisable at End	$ 0