Net Loss Per Share Applicable to Common Shareholders (Tables)

3 Months Ended

12 Months Ended

Mar. 31, 2022

Dec. 31, 2021

Earnings Per Share Reconciliation [Abstract]

Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]

The following table sets forth the computation of loss per share for the three months ended March 31, 2022, and 2021, respectively:

	For the Three Months Ended
	March 31,
	2022			2021
Numerator:
Net loss applicable to common shareholders	$	(3,724,886	)	$	(2,754,952	)
Denominator:
Weighted average common shares outstanding		213,703,195			187,152,300
Net loss per share:
Basic and diluted	$	(0.02	)	$	(0.01	)

The following table sets forth the computation of loss per share for the years ended December 31, 2021 and 2020, respectively:

	For the Years Ended
	December 31,
	2021			2020
Numerator:
Net loss applicable to common shareholders	$	(11,226,366	)	$	(2,936,129	)
Denominator:
Weighted average common shares outstanding		203,000,201			105,177,272
Net loss per share:
Basic and diluted	$	(0.06	)	$	(0.03	)

Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]

The Company excluded all common equivalent shares outstanding for warrants, options, and convertible instruments to purchase common stock from the calculation of diluted net loss per share because all such securities are antidilutive for the periods presented. As of March 31, 2022, and 2021, the following shares were issuable and excluded from the calculation of diluted loss:

	For the Three Months Ended
	March 31,
	2022		2021
Common stock options		18,671,211		10,967,879
Common stock purchase warrants		31,405,000		12,600,000
Convertible Preferred Stock Series C		4,362,575		12,600,000
Convertible Preferred Stock Series D		13,020,000		-
Accrued interest on Preferred Stock		1,230,858		72,657
Potentially dilutive securities		68,689,644		36,240,536

As of December 31, 2021 and 2020, the following shares were issuable and excluded from the calculation of diluted loss:

	December 31,
	2021		2020
Convertible Notes		-		79,475,904
Options		18,746,211		13,453,879
Warrants		29,820,000		-
Preferred Stock		17,382,575		-
Accrued Interest		872,160		92,253
Total		66,820,946		93,022,036