UNITED STATES
SECURITIES AND EXCHANGE COMMISSION

Washington, DC 20549

SCHEDULE 14A INFORMATION

Consent Revocation Statement Pursuant to Section 14(a)
of the Securities Exchange Act of 1934 (Amendment No.    )

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þ     Definitive Additional Materials
o     Soliciting Material Pursuant to § 240.14a-12

CYTRX CORPORATION

(Name of Registrant as Specified in Its Charter)

N/A
(Name of Person(s) Filing Proxy Statement if other than the Registrant)

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11726 San Vicente Boulevard, Suite 650
Los Angeles, California 90049

June 15, 2009

Dear Stockholder:

You recently received proxy materials in connection with the annual meeting of stockholders of CytRx Corporation to be held on Wednesday, July 1, 2009, and according to our latest records, your PROXY VOTE for this meeting STILL HAS NOT BEEN RECEIVED.

CytRx Corporation is asking stockholders to vote on the following agenda:

§	Proposal 1: The election of one director,
§	Proposal 2: To approve an amendment to the 2000 Long-Term Incentive Plan to allow for a one-time stock option repricing program;
§	Proposal 3: To approve the adoption of the 2008 Stock Incentive Plan
§	Proposal 4: To ratify the appointment of independent auditors.

Please refer to the proxy materials previously mailed to you for additional information about these important proposals.

The Board of Directors fully recommend a “FOR” vote on the proposals.

Regardless of the number of shares you own, it is important that they be represented at the special shareholders meeting. Your vote matters to us and we need your support.

Please vote your shares now so that your vote can be counted without delay. Voting is easy. You may utilize one of the options below to ensure that your vote is promptly recorded in time for the special stockholders meeting:

§	VOTE BY TOUCHTONE PHONE: You may cast your vote by calling the toll-free number on the enclosed proxy card. Follow the instructions on your proxy card to cast your ballot.
§	VOTE THROUGH THE INTERNET: You may cast your vote by logging into the Internet address located on the enclosed proxy card and follow the instructions on the website.
§	VOTE BY MAIL: You may cast your vote by mail by signing, dating and mailing the enclosed proxy card in the postage-prepaid return envelope provided.

YOUR PARTICIPATION IS IMPORTANT — PLEASE VOTE TODAY!

If you have any questions relating to the special shareholders meeting, voting your shares, or need to request additional proxy materials, you may call our proxy specialists toll-free at 800-217-0538 between 9:00 a.m. and 10:00 p.m. Eastern Time, Monday through Friday.

We appreciate your continued support.

IF YOU HAVE RECENTLY MAILED YOUR PROXY OR CAST YOUR VOTE BY PHONE OR OVER THE
INTERNET, PLEASE ACCEPT OUR THANKS AND DISREGARD THIS REQUEST.