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Stock Based Compensation, by Exercise Price Range (Details)
$ / shares in Units, $ in Millions
9 Months Ended
Sep. 30, 2017
USD ($)
$ / shares
shares
Dec. 31, 2016
$ / shares
shares
Stock Options [Member]    
Share based compensation, shares authorized under significant ranges of outstanding stock option plans in period [Abstract]    
Number of Options (in shares) | shares 2,535,651  
Weighted-Average Remaining Contractual Life 7 years 3 months 4 days  
Weighted-Average Exercise Price (in dollars per share) $ 14.28  
Number of Options Exercisable (in shares) | shares 2,059,784  
Weighted-Average Remaining Contractual Life 6 years 10 months 28 days  
Weighted-Average Exercise Price, Options Exercisable (in dollars per share) $ 16.02  
Aggregate intrinsic value of outstanding options | $ $ 0  
Aggregate intrinsic value of options vested | $ $ 0  
Closing price of the common stock (in dollars per share) $ 2.46  
Warrants [Member]    
Share based compensation, shares authorized under significant ranges of outstanding stock option plans in period [Abstract]    
Warrants outstanding (in shares) | shares 3,980,781 5,417,132
Weighted-average exercise price of warrants outstanding (in dollars per share) 4.26 4.08
Range $2.46 - 9.00 [Member] | Stock Options [Member]    
Share based compensation, shares authorized under significant ranges of outstanding stock option plans in period [Abstract]    
Range of Exercise Prices, Lower Range (in dollars per share) $ 2.46  
Range of Exercise Prices, Upper Range (in dollars per share) $ 9.00  
Number of Options (in shares) | shares 635,787  
Weighted-Average Remaining Contractual Life 9 years 2 months 23 days  
Weighted-Average Exercise Price (in dollars per share) $ 2.70  
Number of Options Exercisable (in shares) | shares 328,075  
Weighted-Average Remaining Contractual Life 9 years 3 months 4 days  
Weighted-Average Exercise Price, Options Exercisable (in dollars per share) $ 2.76  
Range $9.06 - 15.00 [Member] | Stock Options [Member]    
Share based compensation, shares authorized under significant ranges of outstanding stock option plans in period [Abstract]    
Range of Exercise Prices, Lower Range (in dollars per share) 9.06  
Range of Exercise Prices, Upper Range (in dollars per share) $ 15.00  
Number of Options (in shares) | shares 1,266,229  
Weighted-Average Remaining Contractual Life 7 years 18 days  
Weighted-Average Exercise Price (in dollars per share) $ 13.50  
Number of Options Exercisable (in shares) | shares 1,099,463  
Weighted-Average Remaining Contractual Life 6 years 10 months 20 days  
Weighted-Average Exercise Price, Options Exercisable (in dollars per share) $ 13.38  
Range $15.06 - 24.00 [Member] | Stock Options [Member]    
Share based compensation, shares authorized under significant ranges of outstanding stock option plans in period [Abstract]    
Range of Exercise Prices, Lower Range (in dollars per share) 15.06  
Range of Exercise Prices, Upper Range (in dollars per share) $ 24.00  
Number of Options (in shares) | shares 158,207  
Weighted-Average Remaining Contractual Life 6 years 5 months 12 days  
Weighted-Average Exercise Price (in dollars per share) $ 17.28  
Number of Options Exercisable (in shares) | shares 156,818  
Weighted-Average Remaining Contractual Life 6 years 5 months 8 days  
Weighted-Average Exercise Price, Options Exercisable (in dollars per share) $ 17.22  
Range $24.06 - 195.30 [Member] | Stock Options [Member]    
Share based compensation, shares authorized under significant ranges of outstanding stock option plans in period [Abstract]    
Range of Exercise Prices, Lower Range (in dollars per share) 24.06  
Range of Exercise Prices, Upper Range (in dollars per share) $ 195.30  
Number of Options (in shares) | shares 475,428  
Weighted-Average Remaining Contractual Life 5 years 5 months 26 days  
Weighted-Average Exercise Price (in dollars per share) $ 30.90  
Number of Options Exercisable (in shares) | shares 475,428  
Weighted-Average Remaining Contractual Life 5 years 5 months 26 days  
Weighted-Average Exercise Price, Options Exercisable (in dollars per share) $ 30.90