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CONDENSED STATEMENTS OF CASH FLOWS (Unaudited) - USD ($)
6 Months Ended
Jun. 30, 2017
Jun. 30, 2016
Cash flows from operating activities:    
Net loss $ (25,402,401) $ (30,923,335)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 348,843 213,964
Stock-based compensation expense 1,731,484 4,364,886
Fair value adjustment on warrant liabilities 4,336,066 (693,457)
Non-cash litigation settlement due in common stock 0 700,000
Amortization of loan cost and discount 975,743 208,148
Loss on retirement of fixed assets 421,843 3,388
Changes in assets and liabilities:    
Receivables 136,072 4,368,773
Interest receivable 0 28,130
Prepaid expenses and other current assets 1,662,994 1,432,127
Accounts payable 673,635 (844,373)
Accrued expenses and other current liabilities (1,026,781) (4,297,864)
Net cash used in operating activities (16,142,502) (25,439,613)
Cash flows from investing activities:    
Proceeds from the sale of short-term investments 0 35,035,420
Purchases of equipment and furnishings (134,598) (660,758)
Net cash provided by (used in) investing activities (134,598) 34,374,662
Cash flows from financing activities:    
Proceeds from public offering 13,951,218 0
Proceeds from term loan, net 0 24,012,078
Payment of principal on term loan (2,427,362) 0
Net proceeds from exercise of warrants and stock options 2,766,605 704,700
Net cash provided by financing activities 14,290,461 24,716,778
Net increase (decrease) in cash and cash equivalents (1,986,639) 33,651,827
Cash and cash equivalents at beginning of period 56,959,485 22,261,372
Cash and cash equivalents at end of period 54,972,846 55,913,199
Supplemental disclosure of cash flow information:    
Cash paid during the year for interest 1,212,219 752,083
Cash paid for income taxes 800 800
Supplemental disclosure of non-cash activities:    
Warrant liability exercise 1,558,377 0
Preferred stock conversion 7,400 0
Warrants issued in connection with term loan 0 633,749
Equipment and furnishings purchased on credit 0 79,247
Shares issued in connection with the class action settlement $ 0 $ 4,500,000