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CONDENSED STATEMENTS OF CASH FLOWS (Unaudited) - USD ($)
3 Months Ended
Mar. 31, 2017
Mar. 31, 2016
Cash flows from operating activities:    
Net loss $ (11,044,104) $ (12,643,112)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 173,524 102,434
Stock-based compensation expense 931,525 1,325,817
Fair value adjustment on warrant liabilities 32,119 184,272
Amortization of loan cost and discount 715,786 67,150
Loss on retirement of fixed assets 0 387
Non-cash litigation settlement due in common stock 0 700,000
Changes in assets and liabilities:    
Receivables 81,574 3,592,636
Interest receivable 0 28,130
Prepaid expenses and other current assets 789,203 (861,255)
Accounts payable 121,126 (2,172,100)
Accrued expenses and other current liabilities (39,707) (3,415,368)
Net cash used in operating activities (8,238,954) (13,091,009)
Cash flows from investing activities:    
Proceeds from the sale of short-term investments 0 35,035,420
Purchases of equipment and furnishings (103,051) (238,107)
Net cash (used) provided by investing activities (103,051) 34,797,313
Cash flows from financing activities:    
Proceeds from term loan, net of costs 0 24,012,078
Payment of principal on term loan (614,165) 0
Net proceeds from exercise of stock options 0 183,000
Net cash (used) provided by financing activities (614,165) 24,195,078
Net increase (decrease) in cash and cash equivalents (8,956,170) 45,901,382
Cash and cash equivalents at beginning of period 56,959,485 22,261,372
Cash and cash equivalents at end of period 48,003,315 68,162,754
Supplemental disclosure of cash flow information:    
Cash paid during the period for interest 609,944 145,139
Supplemental disclosure of non-cash investing activities:    
Preferred stock conversion 7,400 0
Warrants issued in connection with term loan 0 633,749
Equipment and furnishings purchased on credit $ 14,710 $ 73,474