Stock Options and Equity-Classified Warrants, Schedule of Employee and Non Employee Service Share Based Compensation (Details) - USD ($)	12 Months Ended
	Dec. 31, 2016	Dec. 31, 2015	Dec. 31, 2014
Employees [Member]
Total stock-based compensation expense resulting from stock options and warrants [Abstract]
Allocated employee and non-employee stock-based compensation expense, Total	$ 6,484,303	$ 7,158,804	$ 3,316,106
Non-Employees [Member]
Total stock-based compensation expense resulting from stock options and warrants [Abstract]
Allocated employee and non-employee stock-based compensation expense, Total	235,764	225,852	1,823,242
Research and Development Expense [Member] | Employees [Member]
Total stock-based compensation expense resulting from stock options and warrants [Abstract]
Allocated employee and non-employee stock-based compensation expense, Total	1,822,508	1,590,267	932,482
Research and Development Expense [Member] | Non-Employees [Member]
Total stock-based compensation expense resulting from stock options and warrants [Abstract]
Allocated employee and non-employee stock-based compensation expense, Total	0	0	86,539
General and Administrative Expense [Member] | Employees [Member]
Total stock-based compensation expense resulting from stock options and warrants [Abstract]
Allocated employee and non-employee stock-based compensation expense, Total	4,661,795	5,568,537	2,383,624
General and Administrative Expense [Member] | Non-Employees [Member]
Total stock-based compensation expense resulting from stock options and warrants [Abstract]
Allocated employee and non-employee stock-based compensation expense, Total	$ 235,764	$ 225,852	$ 1,736,703