Equity Transactions (Details) - USD ($)						12 Months Ended
	Jul. 20, 2016	Oct. 26, 2015	Jul. 24, 2015	Mar. 15, 2014	Feb. 05, 2014	Dec. 31, 2016	Dec. 31, 2015	Dec. 31, 2014	Dec. 16, 2016	Dec. 15, 2016	May 25, 2016	Dec. 31, 2013
Class of Stock [Line Items]
Authorized but unissued shares of common stock (in shares)						12,000,000
Number of treasury stock retired (in shares)		199,275
Number of treasury stock retired, value		$ (2,600,000)					$ 0
Stock issued, underwritten public offering, value			$ 28,700,000		$ 86,000,000	$ 25,777,257	$ 26,780,068	$ 80,535,401
Stock issued, underwritten public offering, value (in shares)			10,500,000		13,200,000
Common stock per share value (in dollars per share)			$ 2.75		$ 6.50
Net proceeds from the issuance of common stock			$ 26,800,000		$ 80,500,000
Common stock shares outstanding (in shares)					55,300,000	111,322,895	66,480,065
Common stock shares issued (in shares)						111,322,895	66,480,065		11,540,741
Preferred stock, shares issued (in shares)						0	0
Number of warrants repriced (in shares)									19,397,884
Warrants exercise price (in dollars per share)						$ 30			$ 0.51	$ 0.70
Beneficial conversion feature - Series B preferred stock						$ 0
Common stock issued for litigation settlement (in shares)	28,571,429										1,561,578
Warrants exercised period	1 year
Series B Convertible Preferred Shares [Member]
Class of Stock [Line Items]
Preferred stock, shares issued (in shares)						3,300	0
Preferred stock, stated value						$ 1,000	$ 1,000
Preferred stock, conversion value (in dollars per share)						$ 0.42	$ 0.42
Preferred Stock [Member] | Series B Convertible Preferred Shares [Member]
Class of Stock [Line Items]
Number of treasury stock retired (in shares)							0
Number of treasury stock retired, value							$ 0
Stock issued, underwritten public offering, value						$ 3,300,000	$ 0	$ 0
Stock issued, underwritten public offering, value (in shares)						3,300	0	0
Common stock shares outstanding (in shares)						3,108	0	0				0
Preferred stock, shares issued (in shares)									3,300
Preferred stock, stated value									$ 1,000
Number of preferred shares converted (in shares)						(192)
Preferred stock, conversion value (in dollars per share)						$ 0.42
Beneficial conversion feature - Series B preferred stock						$ 314,286
Common Stock [Member]
Class of Stock [Line Items]
Number of treasury stock retired (in shares)							199,275
Number of treasury stock retired, value							$ 199
Stock issued, underwritten public offering, value						$ 40,112	$ 10,465	$ 13,225
Stock issued, underwritten public offering, value (in shares)						40,112,170	10,465,000	13,225,000
Common stock shares outstanding (in shares)						111,322,895	66,480,065	55,921,986				42,116,964
Number of preferred shares converted (in shares)						457,143
Beneficial conversion feature - Series B preferred stock						$ 0
Employee Stock Option [Member]
Class of Stock [Line Items]
Stock issued during period (in shares)						330,000
Restricted Stock [Member]
Class of Stock [Line Items]
Stock issued during period (in shares)						2,325,581
KTB Tumorforschungs GmbH [Member]
Class of Stock [Line Items]
Stock issued (in shares)				200,000
Fair value of shares issued				$ 800,000