Stock Based Compensation, Schedule of Employee and Non Employee Service Share Based Compensation (Details) - Stock Options and Warrants [Member] - USD ($)	3 Months Ended		9 Months Ended
	Sep. 30, 2016	Sep. 30, 2015	Sep. 30, 2016	Sep. 30, 2015
Employees [Member]
Total stock-based compensation expense resulting from stock options and warrants [Abstract]
Allocated employee and non-employee stock-based compensation expense, Total	$ 1,041,656	$ 885,246	$ 5,186,080	$ 4,313,870
Non-Employees [Member]
Total stock-based compensation expense resulting from stock options and warrants [Abstract]
Allocated employee and non-employee stock-based compensation expense, Total	(5,938)	(27,647)	214,524	206,437
Research and Development Expense [Member] | Employees [Member]
Total stock-based compensation expense resulting from stock options and warrants [Abstract]
Allocated employee and non-employee stock-based compensation expense, Total	455,341	402,292	1,443,347	1,131,072
Research and Development Expense [Member] | Non-Employees [Member]
Total stock-based compensation expense resulting from stock options and warrants [Abstract]
Allocated employee and non-employee stock-based compensation expense, Total	0	0	0	0
General and Administrative Expense [Member] | Employees [Member]
Total stock-based compensation expense resulting from stock options and warrants [Abstract]
Allocated employee and non-employee stock-based compensation expense, Total	586,315	482,954	3,742,733	3,182,798
General and Administrative Expense [Member] | Non-Employees [Member]
Total stock-based compensation expense resulting from stock options and warrants [Abstract]
Allocated employee and non-employee stock-based compensation expense, Total	$ (5,938)	$ (27,647)	$ 214,524	$ 206,437