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CONDENSED STATEMENTS OF CASH FLOWS (Unaudited) - USD ($)
6 Months Ended
Jun. 30, 2016
Jun. 30, 2015
Cash flows from operating activities:    
Net loss $ (30,923,335) $ (29,211,643)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 213,964 165,830
Stock-based compensation expense 4,364,886 3,662,708
Fair value adjustment on warrant liability (693,457) (564,570)
Non-cash litigation settlement due in common stock 700,000 0
Amortization of loan cost and discount 208,148 0
Loss on retirement of fixed assets 3,388 0
Changes in assets and liabilities:    
Receivables 4,368,773 (3,155,714)
Interest receivable 28,130 90,431
Prepaid expenses and other current assets 1,432,127 2,027,993
Accounts payable (844,373) (1,332,633)
Accrued expenses and other current liabilities (4,297,864) 4,382,343
Net cash used in operating activities (25,439,613) (23,935,255)
Cash flows from investing activities:    
Purchase of short-term investments 0 (17,960,256)
Proceeds from the sale of short-term investments 35,035,420 48,579,636
Purchases of equipment and furnishings (660,758) (69,294)
Net cash provided by investing activities 34,374,662 30,550,086
Cash flows from financing activities:    
Proceeds from term loan, net 24,012,078 0
Net proceeds from exercise of warrants and stock options 704,700 0
Net cash provided by financing activities 24,716,778 0
Net increase in cash and cash equivalents 33,651,827 6,614,831
Cash and cash equivalents at beginning of period 22,261,372 32,218,905
Cash and cash equivalents at end of period 55,913,199 38,833,736
Supplemental disclosure of cash flow information:    
Cash paid during the year for interest 752,083 0
Cashless warrant exercises 0 3
Cash paid for income taxes 800 800
Supplemental disclosure of non-cash investing activities:    
Warrants issued in connection with term loan 633,749 0
Equipment and furnishings purchased on credit 79,247 5,022
Shares issued in connection with the class action settlement $ 4,500,000 $ 0