The estimated an annualized forfeiture rate for options granted to employees.

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Contractual term of share-based compensation awards, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

+ References

No definition available.

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Weighted-average price of equity instruments other than options outstanding, including both vested and non-vested instruments.

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Intrinsic value of options vested. Excludes equity instruments other than options, for example, but not limited to, share units, stock appreciation rights, restricted stock.

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Refers to share-based compensation arrangements by share-based payment award, options, exercised, forfeitures, expired in period.

+ References

No definition available.

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Refers to share-based compensation arrangements by share-based payment award, options, exercised, forfeitures, expired in period, weighted average exercise price.

+ References

No definition available.

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Value of restricted share issued.

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No definition available.

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- Definition

Represents the expense recognized during the period arising from equity-based compensation arrangements (for example, shares of stock, unit, stock options or other equity instruments) with employees, directors and certain consultants qualifying for treatment as employees.

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Reference 1: http://www.xbrl.org/2003/role/presentationRef

-Publisher FASB

-Name Accounting Standards Codification

-Topic 718

-SubTopic 10

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- Definition

Exercise price per share or per unit of warrants or rights outstanding.

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-Paragraph i

-Subparagraph 4

-Article 4

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- Definition

Aggregate number of common shares reserved for future issuance.

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-Subparagraph (SX 210.5-02.29)

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- Definition

Unrecognized cost of unvested share-based compensation awards.

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Weighted average period over which unrecognized compensation is expected to be recognized for equity-based compensation plans, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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- Definition

The number of grants made during the period on other than stock (or unit) option plans (for example, phantom stock or unit plan, stock or unit appreciation rights plan, performance target plan).

+ References

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- Definition

Date the equity-based award expires, in CCYY-MM-DD format.

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- Definition

The estimated dividend rate (a percentage of the share price) to be paid (expected dividends) to holders of the underlying shares over the option's term.

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Expected term of share-based compensation awards, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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The estimated measure of the percentage by which a share price is expected to fluctuate during a period. Volatility also may be defined as a probability-weighted measure of the dispersion of returns about the mean. The volatility of a share price is the standard deviation of the continuously compounded rates of return on the share over a specified period. That is the same as the standard deviation of the differences in the natural logarithms of the stock prices plus dividends, if any, over the period.

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For each plan, identification of the award pricing model or other valuation method used in calculating the weighted average fair values disclosed. The model is also used to calculate the compensation expense that is shown within the balance sheet, income statement, and cash flow. Examples of valuation techniques are lattice models (binomial model), closed-form models (Black-Scholes-Merton formula), and a Monte Carlo simulation technique. Fair value is the amount at which an asset or liability could be bought or incurred or sold or settled in a current transaction between willing parties, that is, other than in a forced or liquidation sale. May include disclosures about the assumptions underlying application of the method selected.

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- Definition

The risk-free interest rate assumption that is used in valuing an option on its own shares.

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- Definition

Number of equity instruments other than options outstanding, including both vested and non-vested instruments.

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The difference between the maximum number of shares (or other type of equity) authorized for issuance under the plan (including the effects of amendments and adjustments), and the sum of: 1) the number of shares (or other type of equity) already issued upon exercise of options or other equity-based awards under the plan; and 2) shares (or other type of equity) reserved for issuance on granting of outstanding awards, net of cancellations and forfeitures, if applicable.

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- Definition

The number of shares into which fully or partially vested stock options outstanding as of the balance sheet date can be currently converted under the option plan.

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The weighted-average price as of the balance sheet date at which grantees can acquire the shares reserved for issuance on vested portions of options outstanding and currently exercisable under the stock option plan.

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- Definition

Net number of share options (or share units) granted during the period.

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- Definition

Amount by which the current fair value of the underlying stock exceeds the exercise price of options outstanding.

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- Definition

Number of options outstanding, including both vested and non-vested options.

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-Publisher FASB

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- Definition

Weighted average price at which grantees can acquire the shares reserved for issuance under the stock option plan.

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Number of share instruments newly issued under a share-based compensation plan.

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Weighted average per share amount at which grantees can acquire shares of common stock by exercise of options.

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No definition available.

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- Definition

Weighted average exercise price as of the balance sheet date for those equity-based payment arrangements exercisable and outstanding.

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Weighted average remaining contractual term of exercisable stock options, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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The floor of a customized range of exercise prices for purposes of disclosing shares potentially issuable under outstanding stock option awards on all stock option plans and other required information pertaining to awards in the customized range.

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The number of shares reserved for issuance pertaining to the outstanding exercisable stock options as of the balance sheet date in the customized range of exercise prices for which the market and performance vesting condition has been satisfied.

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The number of shares reserved for issuance pertaining to the outstanding stock options as of the balance sheet date for all option plans in the customized range of exercise prices.

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The weighted average price as of the balance sheet date at which grantees could acquire the underlying shares with respect to all outstanding stock options which are in the customized range of exercise prices.

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Weighted average remaining contractual term of outstanding stock options, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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The ceiling of a customized range of exercise prices for purposes of disclosing shares potentially issuable under outstanding stock option awards on all stock option plans and other required information pertaining to awards in the customized range.

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Price of a single share of a number of saleable stocks of a company.

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Reference 1: http://www.xbrl.org/2003/role/presentationRef

-Publisher FASB

-Name Accounting Standards Codification

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Stock Based Compensation (Details) (USD $)	3 Months Ended
Stock Based Compensation (Details) (USD $)	Mar. 31, 2015	Mar. 31, 2014	Dec. 31, 2014	Feb. 05, 2014
Number of Options (Employees and Non-Employees) [Abstract]
Outstanding at beginning of period (in shares)			100,000
Outstanding at end of period (in shares)			100,000
Share based compensation, shares authorized under significant ranges of outstanding stock option plans in period [Abstract]
Closing price of the common stock (in dollars per share)				$ 6.50us-gaap_SharePrice
Employees [Member]
Share-based compensation arrangement by share-based payment award, fair value assumptions and methodology [Abstract]
Estimated annualized forfeiture rate (in hundredths)	10.00%	12.00%
Employees and Directors [Member]
Share-based compensation arrangement by share-based payment award, fair value assumptions and methodology [Abstract]
Unrecognized compensation expense related to unvested stock options, granted	5,600,000
Unrecognized compensation cost, recognized as expense over a weighted-average period	1 year 1 month 20 days
Senior management [Member]
Share-based compensation arrangement by share-based payment award, fair value assumptions and methodology [Abstract]
Estimated annualized forfeiture rate (in hundredths)	2.00%	2.00%
Directors and nonemployees [Member]
Share-based compensation arrangement by share-based payment award, fair value assumptions and methodology [Abstract]
Estimated annualized forfeiture rate (in hundredths)	0.00%	0.00%
Stock Options [Member]
Share-based compensation arrangement by share-based payment award, fair value assumptions and methodology [Abstract]
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Method Used	Black-Scholes option-pricing model
Contractual term	10 years
Number of Options (Employees and Non-Employees) [Abstract]
Outstanding at beginning of period (in shares)	10,040,735
Granted (in shares)	180,000	270,000
Exercised, forfeitures or expired (in shares)	(56,429)
Outstanding at end of period (in shares)	10,164,306
Options exercisable at end of period (in shares)	6,164,601
Weighted-Average Exercise Price Options [Abstract]
Outstanding at beginning of period (in dollars per share)	2.87
Granted (in dollars per share)	3.15
Exercised, forfeitures or expired (in dollars per share)	8.54
Outstanding at end of period (in dollars per share)	2.84
Options exercisable at end of period (in dollars per share)	3.14
Share based compensation, shares authorized under significant ranges of outstanding stock option plans in period [Abstract]
Number of Options (in shares)	10,164,306
Weighted-Average Remaining Contractual Life	8 years 3 months 14 days
Weighted-Average Exercise Price (in dollars per share)	2.84
Number of Options Exercisable (in shares)	6,164,601
Weighted-Average Remaining Contractual Life	7 years 8 months 16 days
Weighted-Average Exercise Price, Options Exercisable (in dollars per share)	3.14
The aggregate intrinsic value of outstanding options	9,800,000
Aggregate intrinsic value of options vested	5,500,000
Closing price of the common stock (in dollars per share)	3.37
Stock Options [Member] \| Range $ 1.83 - 2.50 [Member]
Share based compensation, shares authorized under significant ranges of outstanding stock option plans in period [Abstract]
Range of Exercise Prices, Lower Range (in dollars per share)	1.83
Range of Exercise Prices, Upper Range (in dollars per share)	2.50
Number of Options (in shares)	7,932,556
Weighted-Average Remaining Contractual Life	8 years 8 months 26 days
Weighted-Average Exercise Price (in dollars per share)	2.19
Number of Options Exercisable (in shares)	4,212,622
Weighted-Average Remaining Contractual Life	8 years 3 months 29 days
Weighted-Average Exercise Price, Options Exercisable (in dollars per share)	2.17
Stock Options [Member] \| Range $ 2.51 - 3.50 [Member]
Share based compensation, shares authorized under significant ranges of outstanding stock option plans in period [Abstract]
Range of Exercise Prices, Lower Range (in dollars per share)	2.51
Range of Exercise Prices, Upper Range (in dollars per share)	3.50
Number of Options (in shares)	954,482
Weighted-Average Remaining Contractual Life	8 years 10 months 20 days
Weighted-Average Exercise Price (in dollars per share)	2.85
Number of Options Exercisable (in shares)	873,054
Weighted-Average Remaining Contractual Life	8 years 10 months 13 days
Weighted-Average Exercise Price, Options Exercisable (in dollars per share)	2.83
Stock Options [Member] \| Range $ 3.51 - 8.00 [Member]
Share based compensation, shares authorized under significant ranges of outstanding stock option plans in period [Abstract]
Range of Exercise Prices, Lower Range (in dollars per share)	3.51
Range of Exercise Prices, Upper Range (in dollars per share)	8.00
Number of Options (in shares)	989,201
Weighted-Average Remaining Contractual Life	5 years 9 months 14 days
Weighted-Average Exercise Price (in dollars per share)	6.27
Number of Options Exercisable (in shares)	790,858
Weighted-Average Remaining Contractual Life	5 years 0 months 4 days
Weighted-Average Exercise Price, Options Exercisable (in dollars per share)	6.50
Stock Options [Member] \| Range $ 8.01 - 32.55 [Member]
Share based compensation, shares authorized under significant ranges of outstanding stock option plans in period [Abstract]
Range of Exercise Prices, Lower Range (in dollars per share)	8.01
Range of Exercise Prices, Upper Range (in dollars per share)	32.55
Number of Options (in shares)	288,067
Weighted-Average Remaining Contractual Life	2 years 6 months 22 days
Weighted-Average Exercise Price (in dollars per share)	9.00
Number of Options Exercisable (in shares)	288,067
Weighted-Average Remaining Contractual Life	2 years 6 months 22 days
Weighted-Average Exercise Price, Options Exercisable (in dollars per share)	9.00
Stock Options [Member] \| Employees [Member]
Number of Options (Employees and Non-Employees) [Abstract]
Outstanding at beginning of period (in shares)	9,348,592
Granted (in shares)	180,000
Exercised, forfeitures or expired (in shares)	0
Outstanding at end of period (in shares)	9,528,592
Options exercisable at end of period (in shares)	5,528,887
Stock Options [Member] \| Non employees [Member]
Number of Options (Employees and Non-Employees) [Abstract]
Outstanding at beginning of period (in shares)	692,143
Granted (in shares)	0
Exercised, forfeitures or expired (in shares)	(56,429)
Outstanding at end of period (in shares)	635,714
Options exercisable at end of period (in shares)	635,714
Stock Options And Warrants [Member]
Share-based compensation arrangement by share-based payment award, fair value assumptions and methodology [Abstract]
Risk-free interest rate (in hundredths)	2.20%	1.98%
Expected volatility (in hundredths)	84.30%
Expected lives	10 years
Expected dividend yield (in hundredths)	0.00%	0.00%
Stock Options And Warrants [Member] \| Employees [Member]
Total stock-based compensation expense resulting from stock options and warrants [Abstract]
Allocated employee and non-employee stock-based compensation expense, Total	1,291,342	487,113
Stock Options And Warrants [Member] \| Non-Employees [Member]
Total stock-based compensation expense resulting from stock options and warrants [Abstract]
Allocated employee and non-employee stock-based compensation expense, Total	93,551	278,531
Stock Options And Warrants [Member] \| Research and Development Expense [Member] \| Employees [Member]
Total stock-based compensation expense resulting from stock options and warrants [Abstract]
Allocated employee and non-employee stock-based compensation expense, Total	335,938	175,153
Stock Options And Warrants [Member] \| Research and Development Expense [Member] \| Non-Employees [Member]
Total stock-based compensation expense resulting from stock options and warrants [Abstract]
Allocated employee and non-employee stock-based compensation expense, Total	0	86,539
Stock Options And Warrants [Member] \| General and Administrative Expense [Member] \| Employees [Member]
Total stock-based compensation expense resulting from stock options and warrants [Abstract]
Allocated employee and non-employee stock-based compensation expense, Total	955,404	311,960
Stock Options And Warrants [Member] \| General and Administrative Expense [Member] \| Non-Employees [Member]
Total stock-based compensation expense resulting from stock options and warrants [Abstract]
Allocated employee and non-employee stock-based compensation expense, Total	93,551	191,992
Stock Options And Warrants [Member] \| Minimum [Member]
Share-based compensation arrangement by share-based payment award, fair value assumptions and methodology [Abstract]
Expected volatility (in hundredths)		87.80%
Expected lives		6 years
Stock Options And Warrants [Member] \| Maximum [Member]
Share-based compensation arrangement by share-based payment award, fair value assumptions and methodology [Abstract]
Expected volatility (in hundredths)		89.60%
Expected lives		10 years
Restricted Stock [Member]
Total stock-based compensation expense resulting from stock options and warrants [Abstract]
Allocated employee and non-employee stock-based compensation expense, Total	0	154,578
Warrants [Member]
Weighted-Average Exercise Price Options [Abstract]
Share-based compensation arrangement by share-based payment award, shares issued in period (in shares)		25,000
Exercise price of warrants (in dollars per share)		5.60
Share based compensation, shares authorized under significant ranges of outstanding stock option plans in period [Abstract]
Warrants outstanding (in shares)	7,292,617		7,349,760
Weighted-average price of warrants outstanding (in dollars per share)	4.29		4.27
2000 Long Term Incentive Plan [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-based compensation, shares subject to stock options (in shares)	700,000
Expiration date	Aug. 06, 2010
Share-based compensation, shares available for future grant (in shares)	0
2008 Stock Incentive Plan [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-based compensation, shares subject to stock options (in shares)	9,500,000
Share-based compensation, shares available for future grant (in shares)	500,000
2008 Stock Incentive Plan [Member] \| Restricted Stock [Member] \| Senior management [Member]
Weighted-Average Exercise Price Options [Abstract]
Restricted stock granted (in shares)	100,000
Value of restricted shares issued	627,000