X0201 4 2003-08-12 0 0000792977 ADVANCED MAGNETICS INC AVM 0001225854 JACOBS PAULA C/O ADVANCED MAGNETICS INC 61 MOONEY STREET CAMBRIDGE MA 02138 0 1 0 0 Vice President Incentive Stock Option (right to buy) 8.42 2003-08-12 4 A 0 2500 8.42 A 2004-08-12 2013-08-12 Common Stock 2500 2500 D Granted pursuant to the Advanced Magnetics, Inc. 2000 Stock Plan. The shares vest in four equal annual installments, with the first installment vesting on this date. /s/ Paula Jacobs 2003-08-14