CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (USD $) In Thousands	9 Months Ended
Sep. 30, 2011	Sep. 30, 2010
Cash flows from operating activities:
Net loss	$ (58,488)	$ (61,373)
Adjustments to reconcile net loss to net cash (used in) provided by operating activities:
Depreciation	1,966	1,781
Non-cash equity-based compensation expense	8,798	10,736
Non-cash income tax benefit	(611)	(462)
Amortization of premium/discount on purchased securities	2,778	904
Fair value adjustment of settlement rights		788
Losses (gains) on investments, net	194	(402)
Changes in operating assets and liabilities:
Accounts receivable, net	(1,284)	19,702
Inventories	2,094	(7,157)
Receivable from collaboration	249	(564)
Prepaid and other current assets	2,163	(2,221)
Accounts payable and accrued expenses	5,083	380
Deferred revenues	(4,829)	49,702
Other long-term liabilities	(260)	(219)
Total adjustments	16,341	72,968
Net cash (used in) provided by operating activities	(42,147)	11,595
Cash flows from investing activities:
Proceeds from sales or maturities of available-for-sale investments	99,096	110,285
Purchases of available-for-sale investments	(93,707)	(234,045)
Capital expenditures	(415)	(1,100)
Net cash provided by (used in) investing activities	4,974	(124,860)
Cash flows from financing activities:
Proceeds from the exercise of stock options	10	1,322
Proceeds from the issuance of common stock, net of underwriting discounts and other expenses		165,559
Proceeds from the issuance of common stock under ESPP	294	642
Net cash provided by financing activities	304	167,523
Net (decrease) increase in cash and cash equivalents	(36,869)	54,258
Cash and cash equivalents at beginning of the period	112,646	50,126
Cash and cash equivalents at end of the period	$ 75,777	$ 104,384

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