CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS (USD $) In Thousands, except Per Share data	3 Months Ended		9 Months Ended
	Sep. 30, 2011	Sep. 30, 2010	Sep. 30, 2011	Sep. 30, 2010
Revenues:
Product sales, net	$ 15,802	$ 15,173	$ 39,905	$ 44,694
License fee and other collaboration revenues	1,707	1,684	6,322	4,213
Royalties	46	35	115	118
Total revenues	17,555	16,892	46,342	49,025
Costs and expenses:
Cost of product sales	2,669	2,274	7,792	5,168
Research and development expenses	14,894	14,031	45,155	41,183
Selling, general and administrative expenses	17,230	17,986	53,690	65,446
Total costs and expenses	34,793	34,291	106,637	111,797
Other income (expense):
Interest and dividend income, net	378	448	1,390	1,323
Gains (losses) on investments, net	14	(396)	(194)	402
Fair value adjustment of settlement rights				(788)
Total other income (expense)	392	52	1,196	937
Net loss before income taxes	(16,846)	(17,347)	(59,099)	(61,835)
Income tax benefit	215	351	611	462
Net loss	$ (16,631)	$ (16,996)	$ (58,488)	$ (61,373)
Net loss per share:
Basic and diluted (in dollars per share)	$ (0.78)	$ (0.81)	$ (2.76)	$ (2.96)
Weighted average shares outstanding used to compute net loss per share:
Basic (in shares)	21,194	21,085	21,169	20,700
Diluted (in shares)	21,194	21,085	21,169	20,700