CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (USD $) In Thousands	6 Months Ended
Jun. 30, 2011	Jun. 30, 2010
Cash flows from operating activities:
Net loss	$ (41,857)	$ (44,377)
Adjustments to reconcile net loss to net cash (used in) provided by operating activities:
Depreciation	1,317	1,174
Non-cash equity-based compensation expense	7,096	9,236
Non-cash income tax benefit	(396)	(111)
Amortization of premium/discount on purchased securities	1,841	258
Fair value adjustment of settlement rights		788
Losses (gains) on investments, net	208	(798)
Changes in operating assets and liabilities:
Accounts receivable, net	972	13,120
Inventories	1,028	(5,787)
Receivable from collaboration	(430)	(1,029)
Prepaid and other current assets	2,382	542
Accounts payable and accrued expenses	1,413	3,929
Deferred revenues	(3,305)	54,669
Other long-term liabilities	(172)	(145)
Total adjustments	11,954	75,846
Net cash (used in) provided by operating activities	(29,903)	31,469
Cash flows from investing activities:
Proceeds from sales or maturities of available-for-sale investments	71,033	67,475
Purchases of available-for-sale investments	(73,912)	(179,919)
Capital expenditures	(212)	(643)
Net cash used in investing activities	(3,091)	(113,087)
Cash flows from financing activities:
Proceeds from the exercise of stock options	10	1,084
Proceeds from the issuance of common stock, net of underwriting discounts and other expenses		165,559
Proceeds from the issuance of common stock under ESPP	294	642
Net cash provided by financing activities	304	167,285
Net (decrease) increase in cash and cash equivalents	(32,690)	85,667
Cash and cash equivalents at beginning of the period	112,646	50,126
Cash and cash equivalents at end of the period	$ 79,956	$ 135,793

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The cash inflow associated with the sale or maturity (principal being due) of securities not classified as either held-to-maturity securities or trading securities which are classified as available-for-sale securities.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
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-URI http://asc.fasb.org/extlink&oid=6943989&loc=d3e3179-108585

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- Definition

The cash inflow associated with the amount received from holders exercising their stock options. This item inherently excludes any excess tax benefit, which the entity may have realized and reported separately.

+ References

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The consolidated profit or loss for the period, net of income taxes, including the portion attributable to the noncontrolling interest.

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The aggregate amount of noncash, equity-based employee remuneration. This may include the value of stock or unit options, amortization of restricted stock or units, and adjustment for officers' compensation. As noncash, this element is an add back when calculating net cash generated by operating activities using the indirect method.

+ References

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