CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS (USD $) In Thousands, except Per Share data	3 Months Ended		6 Months Ended
	Jun. 30, 2011	Jun. 30, 2010	Jun. 30, 2011	Jun. 30, 2010
Revenues:
Product sales, net	$ 13,081	$ 16,226	$ 24,103	$ 29,521
License fee and other collaboration revenues	2,288	2,529	4,615	2,529
Royalties	33	72	69	83
Total revenues	15,402	18,827	28,787	32,133
Costs and expenses:
Cost of product sales	2,082	1,884	5,123	2,894
Research and development expenses	16,695	14,784	30,261	27,152
Selling, general and administrative expenses	16,826	24,004	36,460	47,460
Total costs and expenses	35,603	40,672	71,844	77,506
Other income (expense):
Interest and dividend income, net	452	404	1,012	875
(Losses) gains on investments, net	(209)	794	(208)	798
Fair value adjustment of settlement rights		(788)		(788)
Total other income (expense)	243	410	804	885
Net loss before income taxes	(19,958)	(21,435)	(42,253)	(44,488)
Income tax benefit	396	111	396	111
Net loss	$ (19,562)	$ (21,324)	$ (41,857)	$ (44,377)
Net loss per share:
Basic and diluted (in dollars per share)	$ (0.92)	$ (1.01)	$ (1.98)	$ (2.16)
Weighted average shares outstanding used to compute net loss per share:
Basic (in shares)	21,167	21,017	21,156	20,504
Diluted (in shares)	21,167	21,017	21,156	20,504