CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2019	Dec. 31, 2018	Dec. 31, 2017
Revenues:
Revenues	$ 326,546	$ 472,048	$ 493,967
Costs and expenses:
Cost of product sales	$ 107,193	$ 215,892	$ 161,349
Cost, Product and Service [Extensible List]	us-gaap:ProductMember	us-gaap:ProductMember	us-gaap:ProductMember
Research and development expenses	$ 64,853	$ 44,846	$ 75,017
Acquired in-process research and development	74,856	32,500	65,845
Selling, general and administrative expenses	286,600	227,810	178,151
Impairment of assets	232,336	0	319,246
Restructuring expenses	7,420	0	0
Total costs and expenses	773,258	521,048	799,608
Operating loss	(446,712)	(49,000)	(305,641)
Other income (expense):
Interest expense	(25,709)	(51,971)	(68,382)
Loss on debt extinguishment	0	(35,922)	(10,926)
Interest and dividend income	4,285	5,328	2,810
Other income (expense)	428	(74)	(70)
Total other expense, net	(20,996)	(82,639)	(76,568)
Loss from continuing operations before income taxes	(467,708)	(131,639)	(382,209)
Income tax (benefit) expense	(47)	40,436	(175,521)
Net loss from continuing operations	(467,661)	(172,075)	(206,688)
Discontinued operations:
Income from discontinued operations	0	18,873	10,313
Gain on sale of CBR business	0	87,076	0
Income tax expense	0	2,371	4,388
Net income from discontinued operations	0	103,578	5,925
Net loss	$ (467,661)	$ (68,497)	$ (200,763)
Basic and diluted earnings per share:
Loss from continuing operations (in dollars per share)	$ (13.74)	$ (5.00)	$ (5.92)
Income from discontinued operations (in dollars per share)	0	3.01	0.17
Total (in dollars per share)	$ (13.74)	$ (1.99)	$ (5.75)
Weighted average shares outstanding used to compute earnings per share (basic and diluted) (in shares)	34,030	34,394	34,907
Product sales, net
Revenues:
Revenues	$ 309,985	$ 471,898	$ 493,843
Collaboration revenue
Revenues:
Revenues	16,400	0	0
Other revenues
Revenues:
Revenues	$ 161	$ 150	$ 124