CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Revenues:
Product sales, net	$ 495,645	$ 432,170	$ 341,816
Service revenues, net	114,177	99,604	24,132
License fee, collaboration and other revenues	124	317	52,328
Total revenues	609,946	532,091	418,276
Costs and expenses:
Cost of product sales (excluding impairment)	161,349	96,314	78,509
Cost of services	21,817	20,575	9,992
Research and development expenses	75,017	66,084	42,878
Acquired in-process research and development	65,845	0	0
Selling, general and administrative expenses	259,933	249,870	160,309
Impairment of intangible assets	319,246	19,663	0
Acquisition-related costs	0	0	11,232
Restructuring expenses	0	715	4,136
Total costs and expenses	903,207	453,221	307,056
Operating (loss) income	(293,261)	78,870	111,220
Other income (expense):
Interest expense	(68,382)	(73,153)	(53,251)
Loss on debt extinguishment	(10,926)	0	(10,449)
Interest and dividend income	2,810	3,149	1,512
Other income (expense)	(335)	189	(9,188)
Total other income (expense)	(76,833)	(69,815)	(71,376)
(Loss) income before income taxes	(370,094)	9,055	39,844
Income tax (benefit) expense	(170,866)	11,538	7,065
Net (loss) income	$ (199,228)	$ (2,483)	$ 32,779
Net (loss) income per share:
Basic (USD per share)	$ (5.71)	$ (0.07)	$ 1.04
Diluted (USD per share)	$ (5.71)	$ (0.07)	$ 0.93
Weighted average shares outstanding used to compute net (loss) income per share:
Basic (shares)	34,907	34,346	31,471
Diluted (shares)	34,907	34,346	35,308