Licensing and Other Arrangements - Affimed (Details) - USD ($)	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020
Licensing and other arrangements
Revenue from contracts with customers	$ 36,518,000	$ 27,941,000
License Agreement | Affimed
Licensing and other arrangements
Contract assets	0
Contract liabilities	0
Capitalized contract costs	0
Revenue from contracts with customers	$ 0