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Income Taxes (Tables)
12 Months Ended
Dec. 31, 2014
Income Taxes [Abstract]  
Total provision for income taxes
The total income tax benefit consists of the following (in thousands):

  
Year ended December 31,
 
  
2014
  
2013
  
2012
 
 
Federal income tax (benefit) provision
 
$
-
  
$
(14
)
 
$
(74
)
Total
 
$
-
  
$
(14
)
 
$
(74
)
Reconciliation between the tax provision computed at the federal statutory income tax rate and actual effective income tax rate
Reconciliation between the tax provision computed at the federal statutory income tax rate of 34% and the Company’s actual effective income tax rate is as follows:
 
  
Year ended December 31,
 
  
2014
  
2013
  
2012
 
Federal tax at statutory rate
  
34
%
  
34
%
  
34
%
Warrant valuation
  
40
%
  
-17
%
  
-4
%
Permanent items and other
  
-1
%
  
0
%
  
-1
%
Valuation allowance
  
-73
%
  
-17
%
  
-29
%
Total
  
0
%
  
0
%
  
0
%
Components of net deferred tax assets
The significant components of net deferred tax assets as of December 31, 2014 and 2013 were as follows (in millions):

  
December 31,
 
  
2014
  
2013
 
Capitalized research and development expenses
 
$
50.9
  
$
49.4
 
Net operating loss carryforwards
  
105.0
   
78.4
 
Research and development and other credit carryforwards
  
12.1
   
8.8
 
Other
  
22.1
   
23.5
 
Total deferred tax assets
  
190.1
   
160.1
 
Valuation allowance
  
(190.1
)
  
(160.1
)
Net deferred tax assets
 
$
-
  
$
-
 
Schedule of unrecognized tax benefits
The following table summarizes the Company's activity related to its unrecognized tax benefits (in thousands):

  
2014
  
2013
  
2012
 
Balance at January 1
 
$
4,274
  
$
4,104
  
$
-
 
Increase related to current year tax position
  
720
   
164
   
49
 
Increase related to prior year tax position
  
509
   
6
   
4,055
 
Balance at December 31
 
$
5,503
  
$
4,274
  
$
4,104