Loans and Other Arrangements (Tables)

12 Months Ended

Dec. 31, 2014

Loans and Other Arrangements [Abstract]

Aggregate future principal and final fee payments of interest bearing obligations

Aggregate future principal, final fee payments and discounts of the Company’s total interest bearing obligations - long-term as of December 31, 2014 are as follows (in thousands):

Year Ending December 31,	Total
2015	$	20,276
2016		18,447
		38,723
Less: interest, final payment and discount		(3,186	)
		35,537
Less: current portion		(19,247	)
Total	$	16,290

Interest expense and amortization of debt issuance costs

Interest expense and amortization of debt issuance costs and discounts, recorded as other expense in the accompanying consolidated statements of comprehensive loss for the year ended December 31, 2014, 2013 and 2012 are shown below (in thousands):

	Year ended December 31,
	2014		2013		2012
Interest expense
Servier loan	$	2,330	$	2,152	$	2,097
GECC term loan		1,638		2,064		1,850
Novartis note		312		362		397
Other		23		53		43
Total interest expense	$	4,303	$	4,631	$	4,387