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Compensation and Other Benefit Plans (Tables)
 12 Months Ended
Dec. 31, 2012
Compensation and Other Benefit Plans [Abstract]  
Stock option activity
A summary of the status of the Company's stock option plans as of December 31, 2012, 2011 and 2010, and changes during the years ended on those dates is presented below:

 
2012
 
 
2011
 
 
2010
 
Options:
 
Shares
 
 
Price*
 
 
Shares
 
 
Price*
 
 
Shares
 
 
Price*
 
Outstanding at beginning of year
 
 
5,053,435
 
 
$
12.55
 
 
 
2,331,450
 
 
$
25.36
 
 
 
1,520,102
 
 
$
38.40
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Granted
 
 
2,351,445
 
 
 
2.59
 
 
 
2,920,166
 
 
 
2.81
 
 
 
978,264
 
 
 
7.07
 
Exercised
 
 
(90,252
)
 
 
1.68
 
 
 
-
 
 
 
-
 
 
 
(19
)
 
 
8.40
 
Forfeited, expired or cancelled
 
 
(526,245
)
 
 
15.84
 
 
 
(198,181
)
 
 
35.56
 
 
 
(166,897
)
 
 
37.26
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Outstanding at end of year
 
 
6,788,383
 
 
 
8.99
 
 
 
5,053,435
 
 
 
12.55
 
 
 
2,331,450
 
 
 
25.36
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Exercisable at end of year
 
 
4,276,834
 
 
$
12.42
 
 
 
3,366,807
 
 
$
16.33
 
 
 
1,259,272
 
 
$
36.51
 

*
Weighted-average exercise price
Unvested RSU activity
Unvested RSU activity for the year ended December 31, 2012 is summarized below:

 
 
 
 
Weighted-
 
 
Number of
 
 
Average Grant-
 
 
Shares
 
 
Date Fair Value
 
Unvested balance at December 31, 2011
 
 
903,874
 
 
$
1.69
 
Granted
 
 
1,292,923
 
 
 
2.83
 
Vested
 
 
(590,862
)
 
 
2.27
 
Forfeited
 
 
(212,055
)
 
 
1.69
 
Unvested balance at December 31, 2012
 
 
1,393,880
 
 
$
2.75
 
Weighted average assumptions
The fair value of stock option awards was estimated using the Black-Scholes model with the following weighted average assumptions for the years ended December 31, 2012, 2011 and 2010:

 
Year Ended December 31,
 
 
2012
 
 
2011
 
 
2010
 
Dividend yield
 
 
0
%
 
 
0
%
 
 
0
%
Expected volatility
 
 
92
%
 
 
88
%
 
 
79
%
Risk-free interest rate
 
 
0.82
%
 
 
1.48
%
 
 
1.67
%
Expected term
 
5.6 years
 
 
5.4 years
 
 
5.3 years
 
Stock-based compensation expense
The following table shows total stock-based compensation expense included in the consolidated statements of comprehensive loss for the years ended December 31, 2012, 2011 and 2010 (in thousands):

 
Year Ended December 31,
 
 
2012
 
 
2011
 
 
2010
 
Research and development
 
$
2,391
 
 
$
3,672
 
 
$
2,302
 
Selling, general and administrative
 
 
1,893
 
 
 
4,087
 
 
 
2,611
 
Total stock-based compensation expense
 
$
4,284
 
 
$
7,759
 
 
$
4,913