X0306 4 2016-12-08 0 0000786947 ACURA PHARMACEUTICALS, INC ACUR 0001416145 Seiser Robert A C/O ACURA PHARMACEUTICALS, INC. 616 N. NORTH COURT SUITE 120 PALATINE IL 60067 0 1 0 0 VP, Controller & Treasurer Stock Options 0.915 2016-12-08 4 A 0 14000 A 2026-12-07 Common Stock 14000 14000 D Exercise price is closing price of Issuer's common stock on December 8, 2016. one-twenty-fourth of shares underlying options vest and are exercisable on the last day of each month commencing December 31, 2016 and ending on November 30, 2018. Option vesting and exercisability is accelerated upon a qualifying change of control. Not Applicable. /s/ Robert A. Seiser 2016-12-09