X0303 4 2010-03-05 0000786947 ACURA PHARMACEUTICALS, INC ACUR 0001212648 CARE CAPITAL II LLC 47 HULFISH STREET SUITE 310 PRINCETON NJ 08542 0 0 1 0 0001223011 CARE CAPITAL INVESTMENTS II LP 47 HULFISH STREET SUITE 310 PRINCETON NJ 08542 0 0 1 0 0001357403 Care Capital Offshore Investments II LP 47 HULFISH STREET SUITE 310 PRINCETON NJ 08542 0 0 1 0 0001352876 Ramsay David Russ 47 HULFISH STREET SUITE 310 PRINCETON NJ 08542 0 0 1 0 Common Stock 2010-03-05 4 S 0 10923 4.77 D 0 I See Footnotes The reportable securities are owned directly by Care Capital Investments II, L.P. and indirectly by Care Capital II, LLC as general partner of Care Capital Investments II, L.P. Care Capital II, LLC disclaims beneficial ownership of the reportable securities and this report shall not be deemed an admission that Care Capital II, LLC is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of its pecuniary interest therein. David Ramsay is one of the managing members of Care Capital II, LLC. Mr. Ramsay disclaims beneficial ownership of the reportable securities and this report shall not be deemed an admission that he is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of his pecuniary interest therein. The reportable securities are owned directly by Care Capital Offshore Investments II, L.P. and indirectly by Care Capital II, LLC as general partner of Care Capital Offshore Investments II, L.P. Care Capital II, LLC disclaims beneficial ownership of the reportable securities and this report shall not be deemed an admission that Care Capital II, LLC is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of its pecuniary interest therein. David Ramsay is one of the managing members of Care Capital II, LLC. Mr. Ramsay disclaims beneficial ownership of the reportable securities and this report shall not be deemed an admission that he is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of his pecuniary interest therein. /s/ David R. Ramsay, Authorized Signatory 2010-03-08