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<edgarSubmission xmlns:ns1="http://www.sec.gov/edgar/common" xmlns="http://www.sec.gov/edgar/thirteenffiler">
  <headerData>
    <submissionType>13F-HR</submissionType>
    <filerInfo>
      <liveTestFlag>LIVE</liveTestFlag>
      <flags>
        <confirmingCopyFlag>false</confirmingCopyFlag>
        <returnCopyFlag>false</returnCopyFlag>
        <overrideInternetFlag>false</overrideInternetFlag>
      </flags>
      <filer>
        <credentials>
          <cik>0000781875</cik>
          <ccc>XXXXXXXX</ccc>
        </credentials>
      </filer>
      <periodOfReport>12-31-2021</periodOfReport>
    </filerInfo>
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    <coverPage>
      <reportCalendarOrQuarter>12-31-2021</reportCalendarOrQuarter>
      <isAmendment>false</isAmendment>
      <filingManager>
        <name>COMERICA SECURITIES,INC.</name>
        <address>
          <ns1:street1>411 W LAFAYETTE BLVD</ns1:street1>
          <ns1:street2>MAIL CODE 3291</ns1:street2>
          <ns1:city>DETROIT</ns1:city>
          <ns1:stateOrCountry>MI</ns1:stateOrCountry>
          <ns1:zipCode>48226</ns1:zipCode>
        </address>
      </filingManager>
      <reportType>13F HOLDINGS REPORT</reportType>
      <form13FFileNumber>028-19494</form13FFileNumber>
      <provideInfoForInstruction5>N</provideInfoForInstruction5>
    </coverPage>
    <signatureBlock>
      <name>Rhonda Brna</name>
      <title>AVP</title>
      <phone>313-222-0232</phone>
      <signature>/s/Rhonda Brna</signature>
      <city>Detroit</city>
      <stateOrCountry>MI</stateOrCountry>
      <signatureDate>02-10-2022</signatureDate>
    </signatureBlock>
    <summaryPage>
      <otherIncludedManagersCount>0</otherIncludedManagersCount>
      <tableEntryTotal>497</tableEntryTotal>
      <tableValueTotal>1559969</tableValueTotal>
      <isConfidentialOmitted>false</isConfidentialOmitted>
    </summaryPage>
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