<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0607</schemaVersion>

    <documentType>3/A</documentType>

    <periodOfReport>2026-04-01</periodOfReport>

    <dateOfOriginalSubmission>2026-04-10</dateOfOriginalSubmission>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0000078003</issuerCik>
        <issuerName>PFIZER INC</issuerName>
        <issuerTradingSymbol>PFE</issuerTradingSymbol>
        <issuerForeignTradingSymbol></issuerForeignTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0002127636</rptOwnerCik>
            <rptOwnerName>Hancock Dennis P</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerNonUSAddressFlag>false</rptOwnerNonUSAddressFlag>
            <rptOwnerStreet1>66 HUDSON BOULEVARD EAST</rptOwnerStreet1>
            <rptOwnerStreet2>ATTN: CORPORATE SECRETARY</rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10001-2192</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isOfficer>1</isOfficer>
            <officerTitle>Executive Vice President</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>1940.0000</value>
                    <footnoteId id="F1"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>By Rule 16b-3 Plan</value>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <derivativeTable></derivativeTable>

    <footnotes>
        <footnote id="F1">This Form 3/A is being filed to include common shares held indirectly in the Pfizer Savings Plan that were inadvertently omitted from the reporting person's original Form 3 filed on April 10, 2026.</footnote>
    </footnotes>

    <remarks>dphxpoa26.htm</remarks>

    <ownerSignature>
        <signatureName>/s/ Shanice A. Reid, by Power of atty, for Dennis P. Hancock</signatureName>
        <signatureDate>2026-04-27</signatureDate>
    </ownerSignature>
</ownershipDocument>
